PE20110308A1 - 1,2,5-oxadiazoles como inhibidores de indolamina 2,3-dioxigenasa - Google Patents

1,2,5-oxadiazoles como inhibidores de indolamina 2,3-dioxigenasa

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Publication number
PE20110308A1
PE20110308A1 PE2011000008A PE2011000008A PE20110308A1 PE 20110308 A1 PE20110308 A1 PE 20110308A1 PE 2011000008 A PE2011000008 A PE 2011000008A PE 2011000008 A PE2011000008 A PE 2011000008A PE 20110308 A1 PE20110308 A1 PE 20110308A1
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PE
Peru
Prior art keywords
amino
indolamine
dioxygenase
inhibitors
carboximidamide
Prior art date
Application number
PE2011000008A
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English (en)
Inventor
Andrew P Combs
Eddy W Yue
Richard B Sparks
Jiacheng Zhou
Qiyan Lin
Lingkai Weng
Tai-Yue Yue
Pingli Liu
Wenyu Zhu
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Incyte Corp
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41128289&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20110308(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of PE20110308A1 publication Critical patent/PE20110308A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/08—1,2,5-Oxadiazoles; Hydrogenated 1,2,5-oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

REFERIDA A UN DERIVADO DE OXADIAZOL DE FORMULA (I), DONDE R1 ES NH2 O CH3; R2 ES Cl, Br, CF3, CH3 O CN; R3 ES H O F; n ES 1 O 2. SON COMPUESTOS PREFERIDOS: 4({2-[(AMINOSULFONIL)AMINO]ETIL}AMINO)-N-(3-BROMO-4-FLUOROFENIL)-N'-HIDROXI-1,2,5-OXADIAZOL-3-CARBOXIMIDAMIDA, N-(3-BROMO-4-FLUOROFENIL)-N'-HIDROXI-4-({2-[(METILSULFONIL)AMINO]ETIL}AMINO)-1,2,5-OXADIAZOL-3-CARBOXIMIDAMIDA, 4-({3-[AMINOSULFONIL)AMINO]PROPIL}AMINO)-N-(3-BROMO-4-FLUOROFENIL)-N'-HIDROXI-1,2,5-OXADIAZOL-3-CARBOXIMIDAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE LA INDOLAMINA-2,3-DIOXIGENASA Y SON UTILES EN EL TRATAMIENTO DEL CANCER
PE2011000008A 2008-07-08 2009-07-07 1,2,5-oxadiazoles como inhibidores de indolamina 2,3-dioxigenasa PE20110308A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7887608P 2008-07-08 2008-07-08
US15087309P 2009-02-09 2009-02-09

Publications (1)

Publication Number Publication Date
PE20110308A1 true PE20110308A1 (es) 2011-06-10

Family

ID=41128289

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PE2011000008A PE20110308A1 (es) 2008-07-08 2009-07-07 1,2,5-oxadiazoles como inhibidores de indolamina 2,3-dioxigenasa

Country Status (37)

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US (12) US8088803B2 (es)
EP (3) EP2315756B9 (es)
JP (2) JP5465720B2 (es)
KR (5) KR101783004B1 (es)
CN (2) CN104042611B (es)
AR (1) AR072490A1 (es)
AU (6) AU2009268739B2 (es)
BR (2) BR122019015876B8 (es)
CA (2) CA2743975C (es)
CL (2) CL2009001554A1 (es)
CO (1) CO6341622A2 (es)
CR (1) CR11871A (es)
CY (1) CY1120617T1 (es)
DK (2) DK2824100T3 (es)
EA (2) EA022669B1 (es)
EC (1) ECSP11010798A (es)
ES (2) ES2524266T3 (es)
HK (2) HK1157692A1 (es)
HR (2) HRP20141094T1 (es)
HU (1) HUE036813T2 (es)
IL (2) IL210402A (es)
LT (1) LT2824100T (es)
ME (1) ME03065B (es)
MX (1) MX2011000235A (es)
MY (3) MY171866A (es)
NO (1) NO2824100T3 (es)
NZ (1) NZ590268A (es)
PE (1) PE20110308A1 (es)
PH (1) PH12014500947B1 (es)
PL (2) PL2824100T3 (es)
PT (2) PT2824100T (es)
RS (2) RS57132B1 (es)
SG (2) SG192485A1 (es)
SI (2) SI2315756T1 (es)
SM (1) SMT201400179B (es)
TW (1) TWI453204B (es)
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