SI9200344B - Postopek za pripravo amlodipin benzensulfonata - Google Patents

Postopek za pripravo amlodipin benzensulfonata Download PDF

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Publication number
SI9200344B
SI9200344B SI9200344A SI9200344A SI9200344B SI 9200344 B SI9200344 B SI 9200344B SI 9200344 A SI9200344 A SI 9200344A SI 9200344 A SI9200344 A SI 9200344A SI 9200344 B SI9200344 B SI 9200344B
Authority
SI
Slovenia
Prior art keywords
methyl
dihydro
ethyl
temperature
pyridinedicarboxylate
Prior art date
Application number
SI9200344A
Other languages
English (en)
Other versions
SI9200344A (en
Inventor
Borut Furlan
Anton Čopar
Alenka Jeriha
Original Assignee
Lek,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lek, filed Critical Lek,
Priority to SI9200344A priority Critical patent/SI9200344B/sl
Priority to CZ932165A priority patent/CZ283041B6/cs
Priority to SK1125-93A priority patent/SK279353B6/sk
Priority to FI934882A priority patent/FI103042B1/fi
Priority to US08/149,735 priority patent/US5389654A/en
Priority to PL93301080A priority patent/PL173645B1/pl
Priority to PL93321792A priority patent/PL174647B1/pl
Priority to DE69304020T priority patent/DE69304020T2/de
Priority to EP93118661A priority patent/EP0599220B1/en
Priority to HRP-9200344A priority patent/HRP931429B1/xx
Priority to RU93052391A priority patent/RU2105759C1/ru
Publication of SI9200344A publication Critical patent/SI9200344A/sl
Priority to US08/295,023 priority patent/US5438145A/en
Publication of SI9200344B publication Critical patent/SI9200344B/sl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Claims (6)

10 PATENTNI ZAHTEVKI 1. Postopek za pripravo 3-etil 5-metil (±) 2-[(2-aminoetoksi)metil]-4-(2-kloro-fenil)-l,4-dihidro-6-metil-3,5-piridindikarboksilata monobenzensulfonata (amlodipin benzensulfonata) s formulo
H označen s tem, da 3-etil 5-metil (±) 2-[2-(N-tritilamino)-etoksimetil]-4-(2-kloro-fenil)-l,4-dihidro-6-metil-3,5-piridindikarboksilat presnovimo z benzensulfonsko kislino v metanolnem ali v vodno metanolnem mediju pri temperaturi od 20°C do refluksne temperature.
2. Postopek po zahtevku 1, označen s tem, da naslovno spojino izoliramo in očistimo vključno z mešanjem po končani presnovi pri temperaturi pod 0°C, da odstranimo trifenilmetil metil eter.
3. Postopek po zahtevku 2, označen s tem, da je temperatura približno -10°C.
4. Postopek po zahtevku 3, označen s tem, da presnovo z benzensulfonsko kislino izvedemo pri refluksni temperaturi.
5. Postopek po zahtevku 1, označen s tem, da presnovo z benzensulfonsko kislino izvedemo pri refluksni temperaturi.
6. 3-etil 5-metil (±) 2-[2-(N-tritilamino)-etoksimetil]-4-(2-kloro-fenil)-l,4-dihidro-6-metil-3,5-piridindikarboksilat. Za LEK, tovarna farmacevtskih in kemičnih izdelkov,d.d.,Ljubljana:
SI9200344A 1992-11-26 1992-11-26 Postopek za pripravo amlodipin benzensulfonata SI9200344B (sl)

Priority Applications (12)

Application Number Priority Date Filing Date Title
SI9200344A SI9200344B (sl) 1992-11-26 1992-11-26 Postopek za pripravo amlodipin benzensulfonata
CZ932165A CZ283041B6 (cs) 1992-11-26 1993-10-13 Způsob přípravy amlodipinbenzensulfonátu
SK1125-93A SK279353B6 (sk) 1992-11-26 1993-10-15 Spôsob prípravy 3-etyl-5-metyl-(+/-)-2-((2-aminoet
FI934882A FI103042B1 (fi) 1992-11-26 1993-11-04 Menetelmä amlodipiinibentseenisulfonaatin valmistamiseksi ja tässä menetelmässä välituotteena toimiva yhdiste
US08/149,735 US5389654A (en) 1992-11-26 1993-11-10 3-ethyl 5-methyl(±)2-[2-(N-tritylamino)ethoxymethyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-6-methyl-3,5-pyridinedicarboxylate
PL93301080A PL173645B1 (pl) 1992-11-26 1993-11-17 Sposób wytwarzania monobenzenosulfonianu (+) 2-[(2-aminoetoksy)metylo]-4-(2-chlorofenylo)-1,4-dihydro-6-metylopirydynodwukarboksylanu-3,5 3-etylowo-5-metylowego
PL93321792A PL174647B1 (pl) 1992-11-26 1993-11-17 Sposób wytwarzania (+) 2-[2-(N-trytyloamino) etoksymetylo]-4-(2-chlorofenylo)-1,4-dihydro-6-metylopirydynodwukarboksylanu-3,5 3-etylowo-5-metylowego i (+)2-[2-(N-trytyloamino) etoksymetylo]-4-(2-chlorofenylo)-1,4-dihydro-6-metylopirydynodwukarboksylan-3,5 3-etylowo-5-metylowy
DE69304020T DE69304020T2 (de) 1992-11-26 1993-11-19 Verfahren zur Herstellung von amlodipin-Benzolsulfonat
EP93118661A EP0599220B1 (en) 1992-11-26 1993-11-19 A process for the preparation of amlodipine benzenesulphonate
HRP-9200344A HRP931429B1 (en) 1992-11-26 1993-11-23 Process for the preparation of amlodipin benzensulphonate
RU93052391A RU2105759C1 (ru) 1992-11-26 1993-11-25 Способ получения 3-этил-5-метил (*01+)2[(2-аминоэтокси)-метил]-4-(2-хлорфенил)-1,4-дигидро-6-метил-3,5-пиридиндикарбоксилатмонобензолсульфоната и промежуточное для него
US08/295,023 US5438145A (en) 1992-11-26 1994-08-25 Process for the preparation of amlodipine benzenesulphonate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SI9200344A SI9200344B (sl) 1992-11-26 1992-11-26 Postopek za pripravo amlodipin benzensulfonata

Publications (2)

Publication Number Publication Date
SI9200344A SI9200344A (en) 1994-06-30
SI9200344B true SI9200344B (sl) 1998-06-30

Family

ID=20431051

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9200344A SI9200344B (sl) 1992-11-26 1992-11-26 Postopek za pripravo amlodipin benzensulfonata

Country Status (9)

Country Link
EP (1) EP0599220B1 (sl)
CZ (1) CZ283041B6 (sl)
DE (1) DE69304020T2 (sl)
FI (1) FI103042B1 (sl)
HR (1) HRP931429B1 (sl)
PL (2) PL174647B1 (sl)
RU (1) RU2105759C1 (sl)
SI (1) SI9200344B (sl)
SK (1) SK279353B6 (sl)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU221810B1 (hu) * 1997-08-12 2003-01-28 EGIS Gyógyszergyár Rt. Eljárás amlodipin-bezilát előállítására és az eljárás intermedierjei
UA72768C2 (en) * 1999-07-05 2005-04-15 Richter Gedeon Vegyeszet A method for obtaining amilodipine benzenesulphonate
EP1435954B1 (en) * 2001-07-06 2010-01-13 LEK Pharmaceuticals D.D. A PROCESS FOR THE PREPARATION OF HIGHlLY PUREAMLODIPINE BENZENESULFONATE
US6680334B2 (en) 2001-08-28 2004-01-20 Pfizer Inc Crystalline material
US6828339B2 (en) * 2001-11-21 2004-12-07 Synthon Bv Amlodipine salt forms and processes for preparing them
SI21233A (sl) * 2002-05-31 2003-12-31 LEK, tovarna farmacevtskih in kemičnih izdelkov, d.d. Kristalni hidratni obliki amlodipin benzensulfonata visoke čistote, postopki za njuno pripravo in uporaba
US6784297B2 (en) 2002-09-04 2004-08-31 Kopran Limited Process for the preparation of anti-ischemic and anti-hypertensive drug amlodipine besylate
EP1407773A1 (en) * 2002-10-08 2004-04-14 Council of Scientific and Industrial Research A process for the preparation of s (-) amlodipine salts
AU2002368531A1 (en) * 2002-12-30 2004-07-22 Eos Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ticaret A.S. Isolation of dihydropyridine derivative and preparation salts thereof
WO2004087172A1 (ja) 2003-03-28 2004-10-14 Nissan Chemical Industries Ltd. Ｔ型カルシウムチャネル阻害剤
WO2007131759A1 (en) * 2006-05-15 2007-11-22 Lek Pharmaceuticals D.D. A process for the preparation of amlodipine benzenesulfonate
ES2524266T3 (es) 2008-07-08 2014-12-04 Incyte Corporation 1,2,5-Oxadiazoles como inhibidores de la indoleamina 2,3-dioxigenasa
EP2380567B1 (en) 2008-12-22 2019-01-16 Pola Chemical Industries Inc. Melanin production inhibitor
CN102516159B (zh) * 2011-12-15 2013-10-09 扬子江药业集团江苏海慈生物药业有限公司 一种苯磺酸左旋氨氯地平的生产方法
US10034939B2 (en) 2012-10-26 2018-07-31 The University Of Chicago Synergistic combination of immunologic inhibitors for the treatment of cancer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK161312C (da) * 1982-03-11 1991-12-09 Pfizer Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden
GB8608335D0 (en) * 1986-04-04 1986-05-08 Pfizer Ltd Pharmaceutically acceptable salts
EP0352863A3 (en) * 1988-07-29 1990-08-22 ZAMBON GROUP S.p.A. 1,4-dihydropyridine dicarboxylic acid derivatives

Also Published As

Publication number Publication date
HRP931429B1 (en) 1997-10-31
CZ283041B6 (cs) 1997-12-17
FI103042B (fi) 1999-04-15
SK279353B6 (sk) 1998-10-07
FI103042B1 (fi) 1999-04-15
RU2105759C1 (ru) 1998-02-27
PL174647B1 (pl) 1998-08-31
HRP931429A2 (en) 1995-12-31
FI934882A (fi) 1994-05-27
DE69304020T2 (de) 1997-03-06
SK112593A3 (en) 1994-11-09
CZ216593A3 (en) 1994-06-15
SI9200344A (en) 1994-06-30
EP0599220B1 (en) 1996-08-14
PL301080A1 (en) 1994-05-30
DE69304020D1 (de) 1996-09-19
FI934882A0 (fi) 1993-11-04
PL173645B1 (pl) 1998-04-30
EP0599220A1 (en) 1994-06-01

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