RU93052391A - Способ получения амлодипинбензолсульфоната и промежуточное для него - Google Patents

Способ получения амлодипинбензолсульфоната и промежуточное для него

Info

Publication number
RU93052391A
RU93052391A RU93052391/04A RU93052391A RU93052391A RU 93052391 A RU93052391 A RU 93052391A RU 93052391/04 A RU93052391/04 A RU 93052391/04A RU 93052391 A RU93052391 A RU 93052391A RU 93052391 A RU93052391 A RU 93052391A
Authority
RU
Russia
Prior art keywords
methyl
obtaining
chlorophenyl
dihydro
ethyl
Prior art date
Application number
RU93052391/04A
Other languages
English (en)
Other versions
RU2105759C1 (ru
Inventor
Фурлан Борут
Чопар Антон
Йериха Аленка
Original Assignee
Лек, Товарна Фармацевтских ин кемичних изделков, Д.Д., Любляна
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SI9200344A external-priority patent/SI9200344B/sl
Application filed by Лек, Товарна Фармацевтских ин кемичних изделков, Д.Д., Любляна filed Critical Лек, Товарна Фармацевтских ин кемичних изделков, Д.Д., Любляна
Publication of RU93052391A publication Critical patent/RU93052391A/ru
Application granted granted Critical
Publication of RU2105759C1 publication Critical patent/RU2105759C1/ru

Links

Claims (1)

  1. Предложен способ получения 3-этил-5-метил(±)2-[(2-аминоэтокси)- метил] -4-(2-хлорфенил)-1,4-дигидро-6-метил-3,5- пиридиндикарбоксилатмонобензолсульфоната (амлодипинбензолсульфоната) формулы, в которой 3-этил-5-метил(±)2-[2-(N-трифенилметиламино) -этоксиметил] -4-(2-хлорфенил)-1,4-дигидро-6-метил-3,5-пиридиндикарбоксилат взаимодействует с бензолсульфокислотой в метанольной или водно-метанольной среде при температуре от 20°С до температуры дефлегмации, и названное соединение отделяется и очищается. Амлодипинбензолсульфонат является ценным антиишемическим и антигипертоническим агентом. Предлагается также промежуточный продукт для синтеза.
RU93052391A 1992-11-26 1993-11-25 Способ получения 3-этил-5-метил (*01+)2[(2-аминоэтокси)-метил]-4-(2-хлорфенил)-1,4-дигидро-6-метил-3,5-пиридиндикарбоксилатмонобензолсульфоната и промежуточное для него RU2105759C1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SIP9200344 1992-11-26
SI9200344A SI9200344B (sl) 1992-11-26 1992-11-26 Postopek za pripravo amlodipin benzensulfonata

Publications (2)

Publication Number Publication Date
RU93052391A true RU93052391A (ru) 1996-06-20
RU2105759C1 RU2105759C1 (ru) 1998-02-27

Family

ID=20431051

Family Applications (1)

Application Number Title Priority Date Filing Date
RU93052391A RU2105759C1 (ru) 1992-11-26 1993-11-25 Способ получения 3-этил-5-метил (*01+)2[(2-аминоэтокси)-метил]-4-(2-хлорфенил)-1,4-дигидро-6-метил-3,5-пиридиндикарбоксилатмонобензолсульфоната и промежуточное для него

Country Status (9)

Country Link
EP (1) EP0599220B1 (ru)
CZ (1) CZ283041B6 (ru)
DE (1) DE69304020T2 (ru)
FI (1) FI103042B (ru)
HR (1) HRP931429B1 (ru)
PL (2) PL173645B1 (ru)
RU (1) RU2105759C1 (ru)
SI (1) SI9200344B (ru)
SK (1) SK279353B6 (ru)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU221810B1 (hu) * 1997-08-12 2003-01-28 EGIS Gyógyszergyár Rt. Eljárás amlodipin-bezilát előállítására és az eljárás intermedierjei
UA72768C2 (en) * 1999-07-05 2005-04-15 Richter Gedeon Vegyeszet A method for obtaining amilodipine benzenesulphonate
ATE454890T1 (de) * 2001-07-06 2010-01-15 Lek Pharmaceuticals Verfahren zur herstellung hochreines amlodipinbenzolsulfonat
US6680334B2 (en) 2001-08-28 2004-01-20 Pfizer Inc Crystalline material
US6828339B2 (en) * 2001-11-21 2004-12-07 Synthon Bv Amlodipine salt forms and processes for preparing them
SI21233A (sl) * 2002-05-31 2003-12-31 LEK, tovarna farmacevtskih in kemičnih izdelkov, d.d. Kristalni hidratni obliki amlodipin benzensulfonata visoke čistote, postopki za njuno pripravo in uporaba
US6784297B2 (en) 2002-09-04 2004-08-31 Kopran Limited Process for the preparation of anti-ischemic and anti-hypertensive drug amlodipine besylate
EP1407773A1 (en) * 2002-10-08 2004-04-14 Council of Scientific and Industrial Research A process for the preparation of s (-) amlodipine salts
WO2004058711A1 (en) * 2002-12-30 2004-07-15 Eos Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ticaret A.S. Isolation of dihydropyridine derivative and preparation salts thereof
JP4539862B2 (ja) 2003-03-28 2010-09-08 日産化学工業株式会社 Ｔ型カルシウムチャネル阻害剤
WO2007131759A1 (en) * 2006-05-15 2007-11-22 Lek Pharmaceuticals D.D. A process for the preparation of amlodipine benzenesulfonate
RS53688B9 (sr) 2008-07-08 2020-01-31 Incyte Holdings Corp 1,2,5-oksadiazoli kao inhibitori indoleamin 2,3-dioksigenaze
SG171722A1 (en) 2008-12-22 2011-07-28 Pola Chem Ind Inc Melanin production inhibitor
CN102516159B (zh) * 2011-12-15 2013-10-09 扬子江药业集团江苏海慈生物药业有限公司 一种苯磺酸左旋氨氯地平的生产方法
EP2911669B1 (en) 2012-10-26 2024-04-10 The University of Chicago Synergistic combination of immunologic inhibitors for the treatment of cancer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK161312C (da) * 1982-03-11 1991-12-09 Pfizer Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden
GB8608335D0 (en) * 1986-04-04 1986-05-08 Pfizer Ltd Pharmaceutically acceptable salts
EP0352863A3 (en) * 1988-07-29 1990-08-22 ZAMBON GROUP S.p.A. 1,4-dihydropyridine dicarboxylic acid derivatives

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