JPS5731663A - Novel aminoalkyl ester derivative of 1,4-dihydropyridene-3, 5-dicarboxylic acid - Google Patents
Novel aminoalkyl ester derivative of 1,4-dihydropyridene-3, 5-dicarboxylic acidInfo
- Publication number
- JPS5731663A JPS5731663A JP5268281A JP5268281A JPS5731663A JP S5731663 A JPS5731663 A JP S5731663A JP 5268281 A JP5268281 A JP 5268281A JP 5268281 A JP5268281 A JP 5268281A JP S5731663 A JPS5731663 A JP S5731663A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- formula
- substituent group
- dihydropyridene
- dicarboxylic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A compound of formula I (R1 is alkyl; R2 is alkyl which may have a substituent group, etc.; R5 and R6 are H, nitro, etc.; R7 is alkyl; R9 is alkyl which may have a substituent group, etc.) and formela II (R3 is alkyl which may have a substituent group; R4" is alkyl having a substituent group) and a salt thereof.
EXAMPLE: 3-Isopropyl 5-N-methyl-N-p-methylbenzylaminoethyl 2,6-dimethyl-4- (3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.
USE: A hypotensive agent and a vasodilator, particularly coronary and cerebral blood vessels. The salt thereof is readily soluble in water and usable as an injection. PEOCESSAn acylacetic ester of formula III is reacted with an aldehyde of formula IV and a compound of formula V to give the compound of formula I.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5268281A JPS5919938B2 (en) | 1981-04-08 | 1981-04-08 | Method for producing novel 1,4-dihydropyridine-3,5-dicarboxylic acid aminoalkyl ester derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5268281A JPS5919938B2 (en) | 1981-04-08 | 1981-04-08 | Method for producing novel 1,4-dihydropyridine-3,5-dicarboxylic acid aminoalkyl ester derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5731663A true JPS5731663A (en) | 1982-02-20 |
JPS5919938B2 JPS5919938B2 (en) | 1984-05-09 |
Family
ID=12921650
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP5268281A Expired JPS5919938B2 (en) | 1981-04-08 | 1981-04-08 | Method for producing novel 1,4-dihydropyridine-3,5-dicarboxylic acid aminoalkyl ester derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5919938B2 (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58159462A (en) * | 1982-03-17 | 1983-09-21 | Yoshitomi Pharmaceut Ind Ltd | 1,4-dihydropyridine-3,5-dicarboxylic acid ester derivative |
JPS59222474A (en) * | 1983-06-02 | 1984-12-14 | Teijin Ltd | 1,4-dihydropyridine-3,5-dicarboxylic acid diester derivative, its preparation and drug containing said derivative as active component |
JPS59227859A (en) * | 1983-06-08 | 1984-12-21 | Teijin Ltd | 1,4-dihydropyridine-3,5-dicarboxylic acid diester derivative, its preparation and drug containing it as active ingredient |
JPS6097955A (en) * | 1983-11-01 | 1985-05-31 | Teijin Ltd | Production of 1,4-dihydropyridine-3,5-dicarboxylic acid diester derivative |
US4578395A (en) * | 1983-06-02 | 1986-03-25 | Teijin Limited | Certain aralkylaminoalkyl esters of 1,4 dihydropyridines as antihypertensive |
US4771057A (en) * | 1986-02-03 | 1988-09-13 | University Of Alberta | Reduced pyridyl derivatives with cardiovascular regulating properties |
US4824855A (en) * | 1985-10-22 | 1989-04-25 | Sanwa Kagaku Kenkyusho Co., Ltd. | 1,4-dihydropyridine derivatives |
-
1981
- 1981-04-08 JP JP5268281A patent/JPS5919938B2/en not_active Expired
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58159462A (en) * | 1982-03-17 | 1983-09-21 | Yoshitomi Pharmaceut Ind Ltd | 1,4-dihydropyridine-3,5-dicarboxylic acid ester derivative |
JPS59222474A (en) * | 1983-06-02 | 1984-12-14 | Teijin Ltd | 1,4-dihydropyridine-3,5-dicarboxylic acid diester derivative, its preparation and drug containing said derivative as active component |
US4578395A (en) * | 1983-06-02 | 1986-03-25 | Teijin Limited | Certain aralkylaminoalkyl esters of 1,4 dihydropyridines as antihypertensive |
JPH0155269B2 (en) * | 1983-06-02 | 1989-11-22 | Teijin Ltd | |
JPS59227859A (en) * | 1983-06-08 | 1984-12-21 | Teijin Ltd | 1,4-dihydropyridine-3,5-dicarboxylic acid diester derivative, its preparation and drug containing it as active ingredient |
JPH0257066B2 (en) * | 1983-06-08 | 1990-12-03 | Teijin Ltd | |
JPS6097955A (en) * | 1983-11-01 | 1985-05-31 | Teijin Ltd | Production of 1,4-dihydropyridine-3,5-dicarboxylic acid diester derivative |
JPH0160466B2 (en) * | 1983-11-01 | 1989-12-22 | Teijin Ltd | |
US4824855A (en) * | 1985-10-22 | 1989-04-25 | Sanwa Kagaku Kenkyusho Co., Ltd. | 1,4-dihydropyridine derivatives |
US4771057A (en) * | 1986-02-03 | 1988-09-13 | University Of Alberta | Reduced pyridyl derivatives with cardiovascular regulating properties |
Also Published As
Publication number | Publication date |
---|---|
JPS5919938B2 (en) | 1984-05-09 |
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