JPS5731663A - Novel aminoalkyl ester derivative of 1,4-dihydropyridene-3, 5-dicarboxylic acid - Google Patents

Novel aminoalkyl ester derivative of 1,4-dihydropyridene-3, 5-dicarboxylic acid

Info

Publication number
JPS5731663A
JPS5731663A JP5268281A JP5268281A JPS5731663A JP S5731663 A JPS5731663 A JP S5731663A JP 5268281 A JP5268281 A JP 5268281A JP 5268281 A JP5268281 A JP 5268281A JP S5731663 A JPS5731663 A JP S5731663A
Authority
JP
Japan
Prior art keywords
alkyl
formula
substituent group
dihydropyridene
dicarboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP5268281A
Other languages
Japanese (ja)
Other versions
JPS5919938B2 (en
Inventor
Masaru Iwanami
Masuo Murakami
Ryutaro Kawai
Tadao Shibanuma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Priority to JP5268281A priority Critical patent/JPS5919938B2/en
Publication of JPS5731663A publication Critical patent/JPS5731663A/en
Publication of JPS5919938B2 publication Critical patent/JPS5919938B2/en
Expired legal-status Critical Current

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  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound of formula I (R1 is alkyl; R2 is alkyl which may have a substituent group, etc.; R5 and R6 are H, nitro, etc.; R7 is alkyl; R9 is alkyl which may have a substituent group, etc.) and formela II (R3 is alkyl which may have a substituent group; R4" is alkyl having a substituent group) and a salt thereof.
EXAMPLE: 3-Isopropyl 5-N-methyl-N-p-methylbenzylaminoethyl 2,6-dimethyl-4- (3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.
USE: A hypotensive agent and a vasodilator, particularly coronary and cerebral blood vessels. The salt thereof is readily soluble in water and usable as an injection. PEOCESSAn acylacetic ester of formula III is reacted with an aldehyde of formula IV and a compound of formula V to give the compound of formula I.
COPYRIGHT: (C)1982,JPO&Japio
JP5268281A 1981-04-08 1981-04-08 Method for producing novel 1,4-dihydropyridine-3,5-dicarboxylic acid aminoalkyl ester derivative Expired JPS5919938B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP5268281A JPS5919938B2 (en) 1981-04-08 1981-04-08 Method for producing novel 1,4-dihydropyridine-3,5-dicarboxylic acid aminoalkyl ester derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5268281A JPS5919938B2 (en) 1981-04-08 1981-04-08 Method for producing novel 1,4-dihydropyridine-3,5-dicarboxylic acid aminoalkyl ester derivative

Publications (2)

Publication Number Publication Date
JPS5731663A true JPS5731663A (en) 1982-02-20
JPS5919938B2 JPS5919938B2 (en) 1984-05-09

Family

ID=12921650

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5268281A Expired JPS5919938B2 (en) 1981-04-08 1981-04-08 Method for producing novel 1,4-dihydropyridine-3,5-dicarboxylic acid aminoalkyl ester derivative

Country Status (1)

Country Link
JP (1) JPS5919938B2 (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58159462A (en) * 1982-03-17 1983-09-21 Yoshitomi Pharmaceut Ind Ltd 1,4-dihydropyridine-3,5-dicarboxylic acid ester derivative
JPS59222474A (en) * 1983-06-02 1984-12-14 Teijin Ltd 1,4-dihydropyridine-3,5-dicarboxylic acid diester derivative, its preparation and drug containing said derivative as active component
JPS59227859A (en) * 1983-06-08 1984-12-21 Teijin Ltd 1,4-dihydropyridine-3,5-dicarboxylic acid diester derivative, its preparation and drug containing it as active ingredient
JPS6097955A (en) * 1983-11-01 1985-05-31 Teijin Ltd Production of 1,4-dihydropyridine-3,5-dicarboxylic acid diester derivative
US4578395A (en) * 1983-06-02 1986-03-25 Teijin Limited Certain aralkylaminoalkyl esters of 1,4 dihydropyridines as antihypertensive
US4771057A (en) * 1986-02-03 1988-09-13 University Of Alberta Reduced pyridyl derivatives with cardiovascular regulating properties
US4824855A (en) * 1985-10-22 1989-04-25 Sanwa Kagaku Kenkyusho Co., Ltd. 1,4-dihydropyridine derivatives

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58159462A (en) * 1982-03-17 1983-09-21 Yoshitomi Pharmaceut Ind Ltd 1,4-dihydropyridine-3,5-dicarboxylic acid ester derivative
JPS59222474A (en) * 1983-06-02 1984-12-14 Teijin Ltd 1,4-dihydropyridine-3,5-dicarboxylic acid diester derivative, its preparation and drug containing said derivative as active component
US4578395A (en) * 1983-06-02 1986-03-25 Teijin Limited Certain aralkylaminoalkyl esters of 1,4 dihydropyridines as antihypertensive
JPH0155269B2 (en) * 1983-06-02 1989-11-22 Teijin Ltd
JPS59227859A (en) * 1983-06-08 1984-12-21 Teijin Ltd 1,4-dihydropyridine-3,5-dicarboxylic acid diester derivative, its preparation and drug containing it as active ingredient
JPH0257066B2 (en) * 1983-06-08 1990-12-03 Teijin Ltd
JPS6097955A (en) * 1983-11-01 1985-05-31 Teijin Ltd Production of 1,4-dihydropyridine-3,5-dicarboxylic acid diester derivative
JPH0160466B2 (en) * 1983-11-01 1989-12-22 Teijin Ltd
US4824855A (en) * 1985-10-22 1989-04-25 Sanwa Kagaku Kenkyusho Co., Ltd. 1,4-dihydropyridine derivatives
US4771057A (en) * 1986-02-03 1988-09-13 University Of Alberta Reduced pyridyl derivatives with cardiovascular regulating properties

Also Published As

Publication number Publication date
JPS5919938B2 (en) 1984-05-09

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