JPS5585563A - Preparation of novel 1,4-dihydropridine-3,5-dicarboxylic acid aminoalkyl ester derivative - Google Patents
Preparation of novel 1,4-dihydropridine-3,5-dicarboxylic acid aminoalkyl ester derivativeInfo
- Publication number
- JPS5585563A JPS5585563A JP15846279A JP15846279A JPS5585563A JP S5585563 A JPS5585563 A JP S5585563A JP 15846279 A JP15846279 A JP 15846279A JP 15846279 A JP15846279 A JP 15846279A JP S5585563 A JPS5585563 A JP S5585563A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- lower alkyl
- compound shown
- dicarboxylic acid
- dihydropridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:The title compound shown by the formula I [R1 is lower alkyl; R4 is H or lower alkyl; R5 and R6 are lower alkyl or group shown by the formula II (A is alkylene; R2 is lower alkyl; R3 is aralkyl or aryl) and R5 differs from R6] and its salt.
EXAMPLE: 2,6-Dimethyl-4-( 3'-nitrophenyl )-1,4-dihydropyridine-3,5-dicarboxylic acid 3-isopropyl ester-5-β-(N-benzyl-N-methyl-amino)ethyl ester hydrochloride.
USE: Being anticipated as a hypotensive agent, antispasmodic and vasodilator, especially vasodilator for coronary and cerebral blood. The salt of the desired compound is easily soluble in water, being usable as an injection.
PROCESS: An acyl acetate shown by the formula III is reacted with an aldehyde shown by the formula IV and a compound shown by the formula V in the presence or absence of a solvent under heating to give the desired compound shown by the formula I. The compound shown by the formula V can be obtained previously by reacting the acyl acetate shown by the formual III with a compound shown by the formula H2NR4.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15846279A JPS5585563A (en) | 1979-12-06 | 1979-12-06 | Preparation of novel 1,4-dihydropridine-3,5-dicarboxylic acid aminoalkyl ester derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15846279A JPS5585563A (en) | 1979-12-06 | 1979-12-06 | Preparation of novel 1,4-dihydropridine-3,5-dicarboxylic acid aminoalkyl ester derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5585563A true JPS5585563A (en) | 1980-06-27 |
JPS566417B2 JPS566417B2 (en) | 1981-02-10 |
Family
ID=15672260
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15846279A Granted JPS5585563A (en) | 1979-12-06 | 1979-12-06 | Preparation of novel 1,4-dihydropridine-3,5-dicarboxylic acid aminoalkyl ester derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5585563A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59227859A (en) * | 1983-06-08 | 1984-12-21 | Teijin Ltd | 1,4-dihydropyridine-3,5-dicarboxylic acid diester derivative, its preparation and drug containing it as active ingredient |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0350906Y2 (en) * | 1988-03-17 | 1991-10-30 | ||
JPH0588363U (en) * | 1992-05-09 | 1993-12-03 | 博 渕上 | Bedding |
-
1979
- 1979-12-06 JP JP15846279A patent/JPS5585563A/en active Granted
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59227859A (en) * | 1983-06-08 | 1984-12-21 | Teijin Ltd | 1,4-dihydropyridine-3,5-dicarboxylic acid diester derivative, its preparation and drug containing it as active ingredient |
JPH0257066B2 (en) * | 1983-06-08 | 1990-12-03 | Teijin Ltd |
Also Published As
Publication number | Publication date |
---|---|
JPS566417B2 (en) | 1981-02-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EXPY | Cancellation because of completion of term | ||
R154 | Certificate of patent or utility model (reissue) |
Free format text: JAPANESE INTERMEDIATE CODE: R154 |