JPS5585563A - Preparation of novel 1,4-dihydropridine-3,5-dicarboxylic acid aminoalkyl ester derivative - Google Patents

Preparation of novel 1,4-dihydropridine-3,5-dicarboxylic acid aminoalkyl ester derivative

Info

Publication number
JPS5585563A
JPS5585563A JP15846279A JP15846279A JPS5585563A JP S5585563 A JPS5585563 A JP S5585563A JP 15846279 A JP15846279 A JP 15846279A JP 15846279 A JP15846279 A JP 15846279A JP S5585563 A JPS5585563 A JP S5585563A
Authority
JP
Japan
Prior art keywords
formula
lower alkyl
compound shown
dicarboxylic acid
dihydropridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15846279A
Other languages
Japanese (ja)
Other versions
JPS566417B2 (en
Inventor
Masaru Iwanami
Masuo Murakami
Kozo Takahashi
Masaharu Fujimoto
Tadao Shibanuma
Ryutaro Kawai
Takaichi Takenaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=15672260&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JPS5585563(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Priority to JP15846279A priority Critical patent/JPS5585563A/en
Publication of JPS5585563A publication Critical patent/JPS5585563A/en
Publication of JPS566417B2 publication Critical patent/JPS566417B2/ja
Granted legal-status Critical Current

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  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:The title compound shown by the formula I [R1 is lower alkyl; R4 is H or lower alkyl; R5 and R6 are lower alkyl or group shown by the formula II (A is alkylene; R2 is lower alkyl; R3 is aralkyl or aryl) and R5 differs from R6] and its salt.
EXAMPLE: 2,6-Dimethyl-4-( 3'-nitrophenyl )-1,4-dihydropyridine-3,5-dicarboxylic acid 3-isopropyl ester-5-β-(N-benzyl-N-methyl-amino)ethyl ester hydrochloride.
USE: Being anticipated as a hypotensive agent, antispasmodic and vasodilator, especially vasodilator for coronary and cerebral blood. The salt of the desired compound is easily soluble in water, being usable as an injection.
PROCESS: An acyl acetate shown by the formula III is reacted with an aldehyde shown by the formula IV and a compound shown by the formula V in the presence or absence of a solvent under heating to give the desired compound shown by the formula I. The compound shown by the formula V can be obtained previously by reacting the acyl acetate shown by the formual III with a compound shown by the formula H2NR4.
COPYRIGHT: (C)1980,JPO&Japio
JP15846279A 1979-12-06 1979-12-06 Preparation of novel 1,4-dihydropridine-3,5-dicarboxylic acid aminoalkyl ester derivative Granted JPS5585563A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15846279A JPS5585563A (en) 1979-12-06 1979-12-06 Preparation of novel 1,4-dihydropridine-3,5-dicarboxylic acid aminoalkyl ester derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15846279A JPS5585563A (en) 1979-12-06 1979-12-06 Preparation of novel 1,4-dihydropridine-3,5-dicarboxylic acid aminoalkyl ester derivative

Publications (2)

Publication Number Publication Date
JPS5585563A true JPS5585563A (en) 1980-06-27
JPS566417B2 JPS566417B2 (en) 1981-02-10

Family

ID=15672260

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15846279A Granted JPS5585563A (en) 1979-12-06 1979-12-06 Preparation of novel 1,4-dihydropridine-3,5-dicarboxylic acid aminoalkyl ester derivative

Country Status (1)

Country Link
JP (1) JPS5585563A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59227859A (en) * 1983-06-08 1984-12-21 Teijin Ltd 1,4-dihydropyridine-3,5-dicarboxylic acid diester derivative, its preparation and drug containing it as active ingredient

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0350906Y2 (en) * 1988-03-17 1991-10-30
JPH0588363U (en) * 1992-05-09 1993-12-03 博 渕上 Bedding

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59227859A (en) * 1983-06-08 1984-12-21 Teijin Ltd 1,4-dihydropyridine-3,5-dicarboxylic acid diester derivative, its preparation and drug containing it as active ingredient
JPH0257066B2 (en) * 1983-06-08 1990-12-03 Teijin Ltd

Also Published As

Publication number Publication date
JPS566417B2 (en) 1981-02-10

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Legal Events

Date Code Title Description
EXPY Cancellation because of completion of term
R154 Certificate of patent or utility model (reissue)

Free format text: JAPANESE INTERMEDIATE CODE: R154