JPS5547656A - 2-(2-substituted aminoethyl)-1,4-dihydropyridine derivative and its derivative - Google Patents
2-(2-substituted aminoethyl)-1,4-dihydropyridine derivative and its derivativeInfo
- Publication number
- JPS5547656A JPS5547656A JP12067578A JP12067578A JPS5547656A JP S5547656 A JPS5547656 A JP S5547656A JP 12067578 A JP12067578 A JP 12067578A JP 12067578 A JP12067578 A JP 12067578A JP S5547656 A JPS5547656 A JP S5547656A
- Authority
- JP
- Japan
- Prior art keywords
- derivative
- lower alkyl
- dihydropyridine
- formula
- substituted aminoethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:2-(2-Substituted aminoethyl)-1,4-dihydropyridine derivative of formula I (R1 is aryl, aromatic heterocycle that may have 1 or 2 substituents as halogen, lower alkoxy or lower alkyl; R2 and R3 are lower alkyl; R4 is lower alkyl; R5 is H, lower alkyl; R6, R7 are lower alkyl, heterocycle).
EXAMPLE: 2-(2-Dimethylaminoethyl)-6-methyl-4-(2-nitrophenyl)-1, 4-dihydropyridine-3, 5-dicarboxylic dimethyl ester.
USE: Antistenocardia, antispasmodic, hypotensor.
PREPARATION: The reaction of a compound of formula II with formaldehyde and an amine of formula III or its salt gives the compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12067578A JPS5547656A (en) | 1978-09-29 | 1978-09-29 | 2-(2-substituted aminoethyl)-1,4-dihydropyridine derivative and its derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12067578A JPS5547656A (en) | 1978-09-29 | 1978-09-29 | 2-(2-substituted aminoethyl)-1,4-dihydropyridine derivative and its derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5547656A true JPS5547656A (en) | 1980-04-04 |
Family
ID=14792146
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12067578A Pending JPS5547656A (en) | 1978-09-29 | 1978-09-29 | 2-(2-substituted aminoethyl)-1,4-dihydropyridine derivative and its derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5547656A (en) |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0089167A2 (en) * | 1982-03-11 | 1983-09-21 | Pfizer Limited | Dihydropyridine anti-ischaemic and antihypertensive agents, processes for their production, and pharmaceutical compositions containing them |
EP0100189A2 (en) * | 1982-07-22 | 1984-02-08 | Pfizer Limited | Dihydropyridine anti-ischaemic and antihypertensive agents |
EP0106462A2 (en) * | 1982-09-04 | 1984-04-25 | Pfizer Limited | Dihydropyridines |
EP0107293A2 (en) * | 1982-09-04 | 1984-05-02 | Pfizer Limited | Dihydropyridines |
US4515799A (en) * | 1983-02-02 | 1985-05-07 | Pfizer Inc. | Dihydropyridine anti-ischaemic and antihypertensive agents |
EP0168841A2 (en) * | 1983-12-19 | 1986-01-22 | Pfizer Limited | Dihydropyridine intermediate |
US4572908A (en) * | 1982-12-21 | 1986-02-25 | Pfizer Inc. | Dihydropyridines |
JPS6157578A (en) * | 1984-08-17 | 1986-03-24 | ジヨン・ワイス・アンド・ブラザー・リミテツド | Heterocyclic compound |
US4590195A (en) * | 1983-03-10 | 1986-05-20 | Pfizer Inc. | 4-aryl-3,5-bis(alkoxycarbonyl)-6-methyl-2-aminoalkyloxymethyl-1,4-dihydropyridine antihypertensive agents |
JPS62240660A (en) * | 1986-04-04 | 1987-10-21 | フアイザ−・リミテツド | Benzenesulfonate of amurodipine |
JPS6341460A (en) * | 1986-08-04 | 1988-02-22 | アデイ−ル エ コンパニ− | Novel dihydrpyridine derivative |
JP2014533717A (en) * | 2011-11-24 | 2014-12-15 | リピダート クタトー フェイレサト エス タナチャド カーエフテー. | 1,4-dihydrpyridine derivatives having Hsp-regulating activity |
-
1978
- 1978-09-29 JP JP12067578A patent/JPS5547656A/en active Pending
Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0089167B1 (en) * | 1982-03-11 | 1986-10-15 | Pfizer Limited | Dihydropyridine anti-ischaemic and antihypertensive agents, processes for their production, and pharmaceutical compositions containing them |
EP0089167A2 (en) * | 1982-03-11 | 1983-09-21 | Pfizer Limited | Dihydropyridine anti-ischaemic and antihypertensive agents, processes for their production, and pharmaceutical compositions containing them |
EP0100189A2 (en) * | 1982-07-22 | 1984-02-08 | Pfizer Limited | Dihydropyridine anti-ischaemic and antihypertensive agents |
US4616024A (en) * | 1982-07-22 | 1986-10-07 | Pfizer Inc. | Dihydropyridine anti-ischaemic and antihypertensive agents |
EP0106462A2 (en) * | 1982-09-04 | 1984-04-25 | Pfizer Limited | Dihydropyridines |
EP0107293A2 (en) * | 1982-09-04 | 1984-05-02 | Pfizer Limited | Dihydropyridines |
US4539322A (en) * | 1982-09-04 | 1985-09-03 | Pfizer Inc. | Dihydropyridine derivatives and their use in treating heart conditions and hypertension |
US4547502A (en) * | 1982-09-04 | 1985-10-15 | Pfizer Inc. | Dihydropyridines and their use in treating cardiac conditions and hypertension |
US4670449A (en) * | 1982-12-21 | 1987-06-02 | Pfizer Inc. | Dihydropyridines |
US4572908A (en) * | 1982-12-21 | 1986-02-25 | Pfizer Inc. | Dihydropyridines |
US4661485A (en) * | 1982-12-21 | 1987-04-28 | Pfizer Inc. | 2-pyrimidylaminoalkoxymethyl-6-methyl-3,5-bis (alkoxycarbony-1)-1,4-dihydropyridine antihypertensive agents |
US4515799A (en) * | 1983-02-02 | 1985-05-07 | Pfizer Inc. | Dihydropyridine anti-ischaemic and antihypertensive agents |
US4590195A (en) * | 1983-03-10 | 1986-05-20 | Pfizer Inc. | 4-aryl-3,5-bis(alkoxycarbonyl)-6-methyl-2-aminoalkyloxymethyl-1,4-dihydropyridine antihypertensive agents |
EP0168841A2 (en) * | 1983-12-19 | 1986-01-22 | Pfizer Limited | Dihydropyridine intermediate |
JPS6157578A (en) * | 1984-08-17 | 1986-03-24 | ジヨン・ワイス・アンド・ブラザー・リミテツド | Heterocyclic compound |
US5068337A (en) * | 1984-08-17 | 1991-11-26 | John Wyeth & Brother Limited | 1,4-dihydropyridines and their ability to inhibit blood platelet aggregation, inhibit thromboxane synthetase and phospholipase |
JPS62240660A (en) * | 1986-04-04 | 1987-10-21 | フアイザ−・リミテツド | Benzenesulfonate of amurodipine |
JPH037668B2 (en) * | 1986-04-04 | 1991-02-04 | Pfizer Ltd | |
JPS6341460A (en) * | 1986-08-04 | 1988-02-22 | アデイ−ル エ コンパニ− | Novel dihydrpyridine derivative |
JP2014533717A (en) * | 2011-11-24 | 2014-12-15 | リピダート クタトー フェイレサト エス タナチャド カーエフテー. | 1,4-dihydrpyridine derivatives having Hsp-regulating activity |
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