JPS5732260A - Mercaptofatty acid derivative and its preparation - Google Patents

Mercaptofatty acid derivative and its preparation

Info

Publication number
JPS5732260A
JPS5732260A JP10778380A JP10778380A JPS5732260A JP S5732260 A JPS5732260 A JP S5732260A JP 10778380 A JP10778380 A JP 10778380A JP 10778380 A JP10778380 A JP 10778380A JP S5732260 A JPS5732260 A JP S5732260A
Authority
JP
Japan
Prior art keywords
formula
lower alkyl
acid derivative
agent
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10778380A
Other languages
Japanese (ja)
Other versions
JPH0147463B2 (en
Inventor
Takeo Komori
Takao Ogawa
Katsumi Asano
Hajime Fujimura
Shiro Morimoto
Mikio Hori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meito Sangyo KK
Original Assignee
Meito Sangyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meito Sangyo KK filed Critical Meito Sangyo KK
Priority to JP10778380A priority Critical patent/JPS5732260A/en
Publication of JPS5732260A publication Critical patent/JPS5732260A/en
Publication of JPH0147463B2 publication Critical patent/JPH0147463B2/ja
Priority to JP25882490A priority patent/JPH03148255A/en
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:The compound of formula I (R1 is H or lower alkyl; R2 is lower alkyl; A is S or SO2; m is 0 or 1; n is 1 or 2; * is asymmetric carbon atom; ** is asymmetric carbon atom when R1 is lower alkyl; provided that when A is S and n is 2, R2 is a group other than CH3), and its salt.
EXAMPLE: N-(2-Mercaptopropionyl)-D,L-methionylsulfone.
USE: Useful as an agent for treating angiotensin-relating hypertension and an agent for treating hepatic diseases.
PROCESS: The compound of formula I is prepared by reacting the carboxylic acid derivative of formula II with the mercaptofatty acid of formula III or its reactive derivative in the presence of an activation agent (e.g. DCC).
COPYRIGHT: (C)1982,JPO&Japio
JP10778380A 1980-08-07 1980-08-07 Mercaptofatty acid derivative and its preparation Granted JPS5732260A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP10778380A JPS5732260A (en) 1980-08-07 1980-08-07 Mercaptofatty acid derivative and its preparation
JP25882490A JPH03148255A (en) 1980-08-07 1990-09-29 Mercaptofatty acid derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10778380A JPS5732260A (en) 1980-08-07 1980-08-07 Mercaptofatty acid derivative and its preparation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP25882490A Division JPH03148255A (en) 1980-08-07 1990-09-29 Mercaptofatty acid derivatives

Publications (2)

Publication Number Publication Date
JPS5732260A true JPS5732260A (en) 1982-02-20
JPH0147463B2 JPH0147463B2 (en) 1989-10-13

Family

ID=14467901

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10778380A Granted JPS5732260A (en) 1980-08-07 1980-08-07 Mercaptofatty acid derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5732260A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1982002890A1 (en) * 1981-02-28 1982-09-02 Iwao Jun Ichi Cyclodextrin clathrate compounds of sulfur-containing compounds
US4879309A (en) * 1988-09-27 1989-11-07 Schering Corporation Mercapto-acylamino acids as antihypertensives
JPH03176465A (en) * 1989-12-05 1991-07-31 Santen Pharmaceut Co Ltd Sulfur-containing amino acid derivative

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5463017A (en) * 1977-10-29 1979-05-21 Santen Pharmaceutical Co Ltd Manufacture of amino acid derivatives
JPS5551054A (en) * 1978-10-11 1980-04-14 Santen Pharmaceut Co Ltd Cysteine derivative

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5463017A (en) * 1977-10-29 1979-05-21 Santen Pharmaceutical Co Ltd Manufacture of amino acid derivatives
JPS5551054A (en) * 1978-10-11 1980-04-14 Santen Pharmaceut Co Ltd Cysteine derivative

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1982002890A1 (en) * 1981-02-28 1982-09-02 Iwao Jun Ichi Cyclodextrin clathrate compounds of sulfur-containing compounds
EP0072868A1 (en) * 1981-02-28 1983-03-02 Santen Pharmaceutical Co., Ltd. Cyclodextrin clathrate compounds of sulfur-containing compounds
US4482709A (en) * 1981-02-28 1984-11-13 Santen Pharmaceutical Co., Ltd. Inclusion compounds of cyclodextrin with sulfur-containing compounds
EP0072868B1 (en) * 1981-02-28 1985-07-24 Santen Pharmaceutical Co., Ltd. Cyclodextrin clathrate compounds of sulfur-containing compounds
US4879309A (en) * 1988-09-27 1989-11-07 Schering Corporation Mercapto-acylamino acids as antihypertensives
JPH03176465A (en) * 1989-12-05 1991-07-31 Santen Pharmaceut Co Ltd Sulfur-containing amino acid derivative

Also Published As

Publication number Publication date
JPH0147463B2 (en) 1989-10-13

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