JPS5732260A - Mercaptofatty acid derivative and its preparation - Google Patents
Mercaptofatty acid derivative and its preparationInfo
- Publication number
- JPS5732260A JPS5732260A JP10778380A JP10778380A JPS5732260A JP S5732260 A JPS5732260 A JP S5732260A JP 10778380 A JP10778380 A JP 10778380A JP 10778380 A JP10778380 A JP 10778380A JP S5732260 A JPS5732260 A JP S5732260A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- lower alkyl
- acid derivative
- agent
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:The compound of formula I (R1 is H or lower alkyl; R2 is lower alkyl; A is S or SO2; m is 0 or 1; n is 1 or 2; * is asymmetric carbon atom; ** is asymmetric carbon atom when R1 is lower alkyl; provided that when A is S and n is 2, R2 is a group other than CH3), and its salt.
EXAMPLE: N-(2-Mercaptopropionyl)-D,L-methionylsulfone.
USE: Useful as an agent for treating angiotensin-relating hypertension and an agent for treating hepatic diseases.
PROCESS: The compound of formula I is prepared by reacting the carboxylic acid derivative of formula II with the mercaptofatty acid of formula III or its reactive derivative in the presence of an activation agent (e.g. DCC).
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10778380A JPS5732260A (en) | 1980-08-07 | 1980-08-07 | Mercaptofatty acid derivative and its preparation |
JP25882490A JPH03148255A (en) | 1980-08-07 | 1990-09-29 | Mercaptofatty acid derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10778380A JPS5732260A (en) | 1980-08-07 | 1980-08-07 | Mercaptofatty acid derivative and its preparation |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP25882490A Division JPH03148255A (en) | 1980-08-07 | 1990-09-29 | Mercaptofatty acid derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5732260A true JPS5732260A (en) | 1982-02-20 |
JPH0147463B2 JPH0147463B2 (en) | 1989-10-13 |
Family
ID=14467901
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10778380A Granted JPS5732260A (en) | 1980-08-07 | 1980-08-07 | Mercaptofatty acid derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5732260A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1982002890A1 (en) * | 1981-02-28 | 1982-09-02 | Iwao Jun Ichi | Cyclodextrin clathrate compounds of sulfur-containing compounds |
US4879309A (en) * | 1988-09-27 | 1989-11-07 | Schering Corporation | Mercapto-acylamino acids as antihypertensives |
JPH03176465A (en) * | 1989-12-05 | 1991-07-31 | Santen Pharmaceut Co Ltd | Sulfur-containing amino acid derivative |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5463017A (en) * | 1977-10-29 | 1979-05-21 | Santen Pharmaceutical Co Ltd | Manufacture of amino acid derivatives |
JPS5551054A (en) * | 1978-10-11 | 1980-04-14 | Santen Pharmaceut Co Ltd | Cysteine derivative |
-
1980
- 1980-08-07 JP JP10778380A patent/JPS5732260A/en active Granted
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5463017A (en) * | 1977-10-29 | 1979-05-21 | Santen Pharmaceutical Co Ltd | Manufacture of amino acid derivatives |
JPS5551054A (en) * | 1978-10-11 | 1980-04-14 | Santen Pharmaceut Co Ltd | Cysteine derivative |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1982002890A1 (en) * | 1981-02-28 | 1982-09-02 | Iwao Jun Ichi | Cyclodextrin clathrate compounds of sulfur-containing compounds |
EP0072868A1 (en) * | 1981-02-28 | 1983-03-02 | Santen Pharmaceutical Co., Ltd. | Cyclodextrin clathrate compounds of sulfur-containing compounds |
US4482709A (en) * | 1981-02-28 | 1984-11-13 | Santen Pharmaceutical Co., Ltd. | Inclusion compounds of cyclodextrin with sulfur-containing compounds |
EP0072868B1 (en) * | 1981-02-28 | 1985-07-24 | Santen Pharmaceutical Co., Ltd. | Cyclodextrin clathrate compounds of sulfur-containing compounds |
US4879309A (en) * | 1988-09-27 | 1989-11-07 | Schering Corporation | Mercapto-acylamino acids as antihypertensives |
JPH03176465A (en) * | 1989-12-05 | 1991-07-31 | Santen Pharmaceut Co Ltd | Sulfur-containing amino acid derivative |
Also Published As
Publication number | Publication date |
---|---|
JPH0147463B2 (en) | 1989-10-13 |
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