JPS5716852A - Nitrile derivative, its preparation, and fibrosis suppressing agent containing the same - Google Patents

Nitrile derivative, its preparation, and fibrosis suppressing agent containing the same

Info

Publication number
JPS5716852A
JPS5716852A JP9092480A JP9092480A JPS5716852A JP S5716852 A JPS5716852 A JP S5716852A JP 9092480 A JP9092480 A JP 9092480A JP 9092480 A JP9092480 A JP 9092480A JP S5716852 A JPS5716852 A JP S5716852A
Authority
JP
Japan
Prior art keywords
formula
compound
preparation
fibrosis
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP9092480A
Other languages
Japanese (ja)
Other versions
JPS6320426B2 (en
Inventor
Jiro Kitamura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kuraray Co Ltd
Original Assignee
Kuraray Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kuraray Co Ltd filed Critical Kuraray Co Ltd
Priority to JP9092480A priority Critical patent/JPS5716852A/en
Publication of JPS5716852A publication Critical patent/JPS5716852A/en
Publication of JPS6320426B2 publication Critical patent/JPS6320426B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:The compound of formula I (R is H or lower alkyl; l is 1W4; m is 0W4; n is 1W2).
EXAMPLE: N-(2-Cyanoethyl)-3,5-dihydroxy-3-methylpentanamide.
USE: Agent for suppressing fibrosis of animal tissue. Effective for the remedy and prevention of fibrosis of organs, hepatocirrhosis, arterioscrelosis, chronic arthritis, etc. Low toxic.
PROCESS: The compound of formula I is prepared by reacting (A) the compound of formula II (X is OH or halogen), the compound of formula III or the compound of formula IV with (B) cyanomethylamine or 2-cyanoethylamine of formula V, pref. in a solvent such as heptane, dioxane, ethanol, etc., at 50W75°C.
COPYRIGHT: (C)1982,JPO&Japio
JP9092480A 1980-07-02 1980-07-02 Nitrile derivative, its preparation, and fibrosis suppressing agent containing the same Granted JPS5716852A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP9092480A JPS5716852A (en) 1980-07-02 1980-07-02 Nitrile derivative, its preparation, and fibrosis suppressing agent containing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9092480A JPS5716852A (en) 1980-07-02 1980-07-02 Nitrile derivative, its preparation, and fibrosis suppressing agent containing the same

Publications (2)

Publication Number Publication Date
JPS5716852A true JPS5716852A (en) 1982-01-28
JPS6320426B2 JPS6320426B2 (en) 1988-04-27

Family

ID=14011972

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9092480A Granted JPS5716852A (en) 1980-07-02 1980-07-02 Nitrile derivative, its preparation, and fibrosis suppressing agent containing the same

Country Status (1)

Country Link
JP (1) JPS5716852A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61249587A (en) * 1985-04-27 1986-11-06 Maeda Kensetsu Kogyo Kk Treatment of harmful substance-contaminated soil at home position
US5338115A (en) * 1992-12-11 1994-08-16 The United States Of America As Represented By The United States Department Of Energy Mixing device for materials with large density differences
US5401880A (en) * 1987-06-04 1995-03-28 Oculon Corporation Chemical prevention or reversal of cataract by phase separation inhibitors
JP2017538403A (en) * 2014-11-26 2017-12-28 ビゾリス インコーポレイテッド Biologically induced mevalonic acid conversion method

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115698200A (en) 2020-07-15 2023-02-03 电化株式会社 Composition and cured body

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61249587A (en) * 1985-04-27 1986-11-06 Maeda Kensetsu Kogyo Kk Treatment of harmful substance-contaminated soil at home position
JPH058078B2 (en) * 1985-04-27 1993-02-01 Maeda Kensetsu Kogyo Kk
US5401880A (en) * 1987-06-04 1995-03-28 Oculon Corporation Chemical prevention or reversal of cataract by phase separation inhibitors
US5338115A (en) * 1992-12-11 1994-08-16 The United States Of America As Represented By The United States Department Of Energy Mixing device for materials with large density differences
JP2017538403A (en) * 2014-11-26 2017-12-28 ビゾリス インコーポレイテッド Biologically induced mevalonic acid conversion method

Also Published As

Publication number Publication date
JPS6320426B2 (en) 1988-04-27

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