JPS5716855A - 4-guanidinomethylcyclohexanecarboxylic acid ester and its preparation - Google Patents
4-guanidinomethylcyclohexanecarboxylic acid ester and its preparationInfo
- Publication number
- JPS5716855A JPS5716855A JP9193180A JP9193180A JPS5716855A JP S5716855 A JPS5716855 A JP S5716855A JP 9193180 A JP9193180 A JP 9193180A JP 9193180 A JP9193180 A JP 9193180A JP S5716855 A JPS5716855 A JP S5716855A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- preparation
- acid ester
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:The compound of formula I (R is naphthyl or pyridyl), or its acid addition salt.
EXAMPLE: Trans-4-guanidinomethylcyclohexanecarboxylic acid 3'-pyridyl ester hydrochloride.
USE: It has excellent protease-inhibiting activity, and useful pharmaceutical activities such as anti-trypsin activity, anti-thrombin activity, etc.
PROCESS: The compound of formula I can be prepared by reacting 4-guanidinomethylcyclohexanecarboxylic acid of formula II or its reactive derivative (e.g. acid chloride) with a compound of formula HO-R.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9193180A JPS5716855A (en) | 1980-07-04 | 1980-07-04 | 4-guanidinomethylcyclohexanecarboxylic acid ester and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9193180A JPS5716855A (en) | 1980-07-04 | 1980-07-04 | 4-guanidinomethylcyclohexanecarboxylic acid ester and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5716855A true JPS5716855A (en) | 1982-01-28 |
JPS6332065B2 JPS6332065B2 (en) | 1988-06-28 |
Family
ID=14040327
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9193180A Granted JPS5716855A (en) | 1980-07-04 | 1980-07-04 | 4-guanidinomethylcyclohexanecarboxylic acid ester and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5716855A (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996006825A1 (en) * | 1994-08-30 | 1996-03-07 | Teikoku Chemical Industries Co., Ltd. | Guanidinomethyl cyclohexane carboxylic ester derivative |
US6001950A (en) * | 1998-09-22 | 1999-12-14 | Borden Chemical, Inc. | Phenol-novolacs with improved optical properties |
US6201094B1 (en) | 1998-09-22 | 2001-03-13 | Borden Chemical, Inc. | Phenol-novolacs with improved optical properties |
US6239248B1 (en) | 1998-09-22 | 2001-05-29 | Borden Chemical, Inc. | Phenol-novolacs with improved optical properties |
US6444703B1 (en) | 1995-12-22 | 2002-09-03 | Teikoku Chemical Industries Co., Ltd. | Cyclohexane carbocyclic ester derivative and cyclodextrin complex and composition for treatment of helicobacter pylori infections |
-
1980
- 1980-07-04 JP JP9193180A patent/JPS5716855A/en active Granted
Non-Patent Citations (1)
Title |
---|
JOURNAL.OF MEDICINAL.CHEMISTRY=1972 * |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996006825A1 (en) * | 1994-08-30 | 1996-03-07 | Teikoku Chemical Industries Co., Ltd. | Guanidinomethyl cyclohexane carboxylic ester derivative |
US6284791B1 (en) | 1994-08-30 | 2001-09-04 | Teikoku Chemical Industries Co., Ltd. | Guanidinomethyl cyclohexane carboxylic acid ester derivatives |
US6831190B1 (en) | 1994-08-30 | 2004-12-14 | Teikoku Chemical Industries Co., Ltd. | Guanidinomethyl cyclohexane carboxylic acid ester derivatives |
US6444703B1 (en) | 1995-12-22 | 2002-09-03 | Teikoku Chemical Industries Co., Ltd. | Cyclohexane carbocyclic ester derivative and cyclodextrin complex and composition for treatment of helicobacter pylori infections |
US6001950A (en) * | 1998-09-22 | 1999-12-14 | Borden Chemical, Inc. | Phenol-novolacs with improved optical properties |
US6140421A (en) * | 1998-09-22 | 2000-10-31 | Borden Chemical, Inc. | Phenol-novolacs with improved optical properties |
US6201094B1 (en) | 1998-09-22 | 2001-03-13 | Borden Chemical, Inc. | Phenol-novolacs with improved optical properties |
US6232399B1 (en) | 1998-09-22 | 2001-05-15 | Borden Chemical, Inc. | Phenol-novolacs with improved optical properties |
US6239248B1 (en) | 1998-09-22 | 2001-05-29 | Borden Chemical, Inc. | Phenol-novolacs with improved optical properties |
US6316583B1 (en) | 1998-09-22 | 2001-11-13 | Borden Chemical, Inc. | Phenol-novolacs with improved optical properties |
Also Published As
Publication number | Publication date |
---|---|
JPS6332065B2 (en) | 1988-06-28 |
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