JPS5681596A - Glucopyranose-nitrosourea derivative, carcinostatic agent consisting of the same and preparation - Google Patents

Glucopyranose-nitrosourea derivative, carcinostatic agent consisting of the same and preparation

Info

Publication number
JPS5681596A
JPS5681596A JP15800079A JP15800079A JPS5681596A JP S5681596 A JPS5681596 A JP S5681596A JP 15800079 A JP15800079 A JP 15800079A JP 15800079 A JP15800079 A JP 15800079A JP S5681596 A JPS5681596 A JP S5681596A
Authority
JP
Japan
Prior art keywords
glucopyranose
formula
preparation
compound
nitrosourea
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP15800079A
Other languages
Japanese (ja)
Inventor
Goro Kimura
Junzo Sekine
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tokyo Tanabe Co Ltd
Original Assignee
Tokyo Tanabe Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tokyo Tanabe Co Ltd filed Critical Tokyo Tanabe Co Ltd
Priority to JP15800079A priority Critical patent/JPS5681596A/en
Priority to FR8025438A priority patent/FR2471386A1/en
Priority to GB8039102A priority patent/GB2075494A/en
Priority to DE19803046393 priority patent/DE3046393A1/en
Priority to IT8026483A priority patent/IT8026483A0/en
Publication of JPS5681596A publication Critical patent/JPS5681596A/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A glucopyranose-nitrosourea derivative of formula I or II (R1 is alkyl having 4W9C side chain, 6W9C cyclohexyl, mono- or trimethylcyclohexyl, 7W8C benzyl, etc.).
EXAMPLE: 3-(iso-Butyl α-D-glucopyranos-6-yl)-1-(2-chloroethyl)-1-nitrosourea.
USE: A carcinostatic agent having a greater carcinostatic activity and lower toxicity than the well-known similar compounds.
PROCESS: An aminoglucopyranose compound of formula III or IV (R2 is amino or acid addition salt thereof) is reacted with a compound of formula V (R3 is nitro or cyano) to give the compound of formula I or X.
COPYRIGHT: (C)1981,JPO&Japio
JP15800079A 1979-12-07 1979-12-07 Glucopyranose-nitrosourea derivative, carcinostatic agent consisting of the same and preparation Pending JPS5681596A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP15800079A JPS5681596A (en) 1979-12-07 1979-12-07 Glucopyranose-nitrosourea derivative, carcinostatic agent consisting of the same and preparation
FR8025438A FR2471386A1 (en) 1979-12-07 1980-12-01 PROCESS FOR THE PRODUCTION OF GLUCOPYRANOSIS-NITROSOUREE COMPOUNDS, NOVEL PRODUCTS OBTAINED WITH ANTI-TUMOR ACTIVITY AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM
GB8039102A GB2075494A (en) 1979-12-07 1980-12-05 New glucopyranose- nitrosourea compounds with antitumor activity, process for producing the same, and pharmaceutical composition containing the said compounds
DE19803046393 DE3046393A1 (en) 1979-12-07 1980-12-05 NEW GLUCOPYRANOSE-NITROSOURIDE COMPOUNDS WITH ANTITUM ORACTIVITY, METHOD FOR PRODUCING THE COMPOUNDS AND THE PHARMACEUTICAL AGENT CONTAINING THEM
IT8026483A IT8026483A0 (en) 1979-12-07 1980-12-05 GLUCOPYRANOSE-NITROSOUREA COMPOUNDS WITH ANTI-TUMOR ACTIVITY, PROCESS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITION WHICH CONTAINS SAID COMPOUNDS.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15800079A JPS5681596A (en) 1979-12-07 1979-12-07 Glucopyranose-nitrosourea derivative, carcinostatic agent consisting of the same and preparation

Publications (1)

Publication Number Publication Date
JPS5681596A true JPS5681596A (en) 1981-07-03

Family

ID=15662052

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15800079A Pending JPS5681596A (en) 1979-12-07 1979-12-07 Glucopyranose-nitrosourea derivative, carcinostatic agent consisting of the same and preparation

Country Status (5)

Country Link
JP (1) JPS5681596A (en)
DE (1) DE3046393A1 (en)
FR (1) FR2471386A1 (en)
GB (1) GB2075494A (en)
IT (1) IT8026483A0 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60502105A (en) * 1983-08-30 1985-12-05 ドロピツク Nitrosourea derivatives, methods for producing the substances, and drugs containing the substances

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101348509B (en) * 2008-08-20 2011-12-07 中国科学院上海有机化学研究所 2-aryl-6-aryl'-glucoside compound, and preparation and use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5126819A (en) * 1974-08-08 1976-03-05 Tokyo Tanabe Co Arukiru nn karubamiru n**22 kuroruechiru n** nitoroso dd gurukopiranoshidojudotaino seizoho
EP0003788B1 (en) * 1978-02-21 1981-12-09 Ciba-Geigy Ag Glycofuranosyl-nitrosourea derivatives, process for their manufacture and their pharmaceutical preparations

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60502105A (en) * 1983-08-30 1985-12-05 ドロピツク Nitrosourea derivatives, methods for producing the substances, and drugs containing the substances

Also Published As

Publication number Publication date
GB2075494A (en) 1981-11-18
FR2471386A1 (en) 1981-06-19
IT8026483A0 (en) 1980-12-05
DE3046393A1 (en) 1982-02-11

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