JPS57197256A - Novel cyclohexanecarboxamide derivative and its preparation - Google Patents
Novel cyclohexanecarboxamide derivative and its preparationInfo
- Publication number
- JPS57197256A JPS57197256A JP56080145A JP8014581A JPS57197256A JP S57197256 A JPS57197256 A JP S57197256A JP 56080145 A JP56080145 A JP 56080145A JP 8014581 A JP8014581 A JP 8014581A JP S57197256 A JPS57197256 A JP S57197256A
- Authority
- JP
- Japan
- Prior art keywords
- novel
- preparation
- formulai
- phenyl
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:A compound of formulaI(R1 and R2 together with N form a 4-alkylpiperazinyl group or R1 is H and R2 is phenyl, cycloalkyl, etc. which may be substituted by an alkyl) and an acid addition salt thereof.
EXAMPLE: 1-(trans-4-guanidinomethylcyclohexanecarbonyl)-4-methylpiperazine hydrochloride.
USE: Useful as a medicine having antiulcer action.
PROCESS: A 4-quanidinomethylcyclohexanecarboxylic acid or a reactive derivative thereof, e.g. an acid chloride, is reacted with an amine of formula II (R1' and R2' together with N form a 4-alkylpiperazinyl or R1' is H and R2' is phenyl, etc. which may be substituted by an alkyl) in an organic solvent, e.g. pyridine, at room temperatureW120°C to give the aimed compound of formulaI.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56080145A JPS57197256A (en) | 1981-05-28 | 1981-05-28 | Novel cyclohexanecarboxamide derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56080145A JPS57197256A (en) | 1981-05-28 | 1981-05-28 | Novel cyclohexanecarboxamide derivative and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57197256A true JPS57197256A (en) | 1982-12-03 |
JPH0139421B2 JPH0139421B2 (en) | 1989-08-21 |
Family
ID=13710098
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56080145A Granted JPS57197256A (en) | 1981-05-28 | 1981-05-28 | Novel cyclohexanecarboxamide derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57197256A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0193965A2 (en) * | 1985-03-08 | 1986-09-10 | Kanebo, Ltd. | Novel guanidinomethylcyclohexancarboxylic acid compounds, processes for preparing them, and pharmaceutical compositions containing them |
US4732916A (en) * | 1985-07-30 | 1988-03-22 | Kabushiki Kaisha Med-Creat | Novel guanidinomethylbenzoic acid derivatives |
EP0268267A2 (en) * | 1986-11-17 | 1988-05-25 | Nippon Hypox Laboratories Incorporated | Guanidinomethylbenzoic acid derivatives, compositions containing the same, processes for preparing the same, and the use of the same in the manufacture of medicaments of therapeutic value |
US6831190B1 (en) | 1994-08-30 | 2004-12-14 | Teikoku Chemical Industries Co., Ltd. | Guanidinomethyl cyclohexane carboxylic acid ester derivatives |
-
1981
- 1981-05-28 JP JP56080145A patent/JPS57197256A/en active Granted
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0193965A2 (en) * | 1985-03-08 | 1986-09-10 | Kanebo, Ltd. | Novel guanidinomethylcyclohexancarboxylic acid compounds, processes for preparing them, and pharmaceutical compositions containing them |
US4732916A (en) * | 1985-07-30 | 1988-03-22 | Kabushiki Kaisha Med-Creat | Novel guanidinomethylbenzoic acid derivatives |
EP0268267A2 (en) * | 1986-11-17 | 1988-05-25 | Nippon Hypox Laboratories Incorporated | Guanidinomethylbenzoic acid derivatives, compositions containing the same, processes for preparing the same, and the use of the same in the manufacture of medicaments of therapeutic value |
US6831190B1 (en) | 1994-08-30 | 2004-12-14 | Teikoku Chemical Industries Co., Ltd. | Guanidinomethyl cyclohexane carboxylic acid ester derivatives |
Also Published As
Publication number | Publication date |
---|---|
JPH0139421B2 (en) | 1989-08-21 |
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