JPS57197256A - Novel cyclohexanecarboxamide derivative and its preparation - Google Patents

Novel cyclohexanecarboxamide derivative and its preparation

Info

Publication number
JPS57197256A
JPS57197256A JP56080145A JP8014581A JPS57197256A JP S57197256 A JPS57197256 A JP S57197256A JP 56080145 A JP56080145 A JP 56080145A JP 8014581 A JP8014581 A JP 8014581A JP S57197256 A JPS57197256 A JP S57197256A
Authority
JP
Japan
Prior art keywords
novel
preparation
formulai
phenyl
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56080145A
Other languages
Japanese (ja)
Other versions
JPH0139421B2 (en
Inventor
Atsushi Tendou
Hiroyasu Sekine
Yoshio Kikawa
Kaname Kindo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Chemiphar Co Ltd
Original Assignee
Nippon Chemiphar Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Chemiphar Co Ltd filed Critical Nippon Chemiphar Co Ltd
Priority to JP56080145A priority Critical patent/JPS57197256A/en
Publication of JPS57197256A publication Critical patent/JPS57197256A/en
Publication of JPH0139421B2 publication Critical patent/JPH0139421B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:A compound of formulaI(R1 and R2 together with N form a 4-alkylpiperazinyl group or R1 is H and R2 is phenyl, cycloalkyl, etc. which may be substituted by an alkyl) and an acid addition salt thereof.
EXAMPLE: 1-(trans-4-guanidinomethylcyclohexanecarbonyl)-4-methylpiperazine hydrochloride.
USE: Useful as a medicine having antiulcer action.
PROCESS: A 4-quanidinomethylcyclohexanecarboxylic acid or a reactive derivative thereof, e.g. an acid chloride, is reacted with an amine of formula II (R1' and R2' together with N form a 4-alkylpiperazinyl or R1' is H and R2' is phenyl, etc. which may be substituted by an alkyl) in an organic solvent, e.g. pyridine, at room temperatureW120°C to give the aimed compound of formulaI.
COPYRIGHT: (C)1982,JPO&Japio
JP56080145A 1981-05-28 1981-05-28 Novel cyclohexanecarboxamide derivative and its preparation Granted JPS57197256A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP56080145A JPS57197256A (en) 1981-05-28 1981-05-28 Novel cyclohexanecarboxamide derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56080145A JPS57197256A (en) 1981-05-28 1981-05-28 Novel cyclohexanecarboxamide derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS57197256A true JPS57197256A (en) 1982-12-03
JPH0139421B2 JPH0139421B2 (en) 1989-08-21

Family

ID=13710098

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56080145A Granted JPS57197256A (en) 1981-05-28 1981-05-28 Novel cyclohexanecarboxamide derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS57197256A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0193965A2 (en) * 1985-03-08 1986-09-10 Kanebo, Ltd. Novel guanidinomethylcyclohexancarboxylic acid compounds, processes for preparing them, and pharmaceutical compositions containing them
US4732916A (en) * 1985-07-30 1988-03-22 Kabushiki Kaisha Med-Creat Novel guanidinomethylbenzoic acid derivatives
EP0268267A2 (en) * 1986-11-17 1988-05-25 Nippon Hypox Laboratories Incorporated Guanidinomethylbenzoic acid derivatives, compositions containing the same, processes for preparing the same, and the use of the same in the manufacture of medicaments of therapeutic value
US6831190B1 (en) 1994-08-30 2004-12-14 Teikoku Chemical Industries Co., Ltd. Guanidinomethyl cyclohexane carboxylic acid ester derivatives

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0193965A2 (en) * 1985-03-08 1986-09-10 Kanebo, Ltd. Novel guanidinomethylcyclohexancarboxylic acid compounds, processes for preparing them, and pharmaceutical compositions containing them
US4732916A (en) * 1985-07-30 1988-03-22 Kabushiki Kaisha Med-Creat Novel guanidinomethylbenzoic acid derivatives
EP0268267A2 (en) * 1986-11-17 1988-05-25 Nippon Hypox Laboratories Incorporated Guanidinomethylbenzoic acid derivatives, compositions containing the same, processes for preparing the same, and the use of the same in the manufacture of medicaments of therapeutic value
US6831190B1 (en) 1994-08-30 2004-12-14 Teikoku Chemical Industries Co., Ltd. Guanidinomethyl cyclohexane carboxylic acid ester derivatives

Also Published As

Publication number Publication date
JPH0139421B2 (en) 1989-08-21

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