JPS5528955A - Novel glycerophosphoric acid derivative, its salt, their preparation, and carcinostatic agent containing the same. - Google Patents
Novel glycerophosphoric acid derivative, its salt, their preparation, and carcinostatic agent containing the same.Info
- Publication number
- JPS5528955A JPS5528955A JP10236278A JP10236278A JPS5528955A JP S5528955 A JPS5528955 A JP S5528955A JP 10236278 A JP10236278 A JP 10236278A JP 10236278 A JP10236278 A JP 10236278A JP S5528955 A JPS5528955 A JP S5528955A
- Authority
- JP
- Japan
- Prior art keywords
- salt
- acid derivative
- glycerophosphoric acid
- novel
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A glycerophosphoric acid derivative of formula I (R1 is 6W22C acyl or 6W22C aliphatic hydrocarbon; R2 is 1W4C substituted alkyl, alkenyl, etc.; R3 is H or 1-3C alkyl; R1 and COR2 are interchangeable each other), or its salt.
EXAMPLE: L-1-Acyl-2-(3-carboxyacryloyl)-glycerine-3-phosphorylcholine.
USE: Low-hemolytic carcinostatic agent effective to ascetes carcinoma and scirrhous carcinoma. Administrable to the remote diseased part.
PROCESS: The compound I is prepared by reacting a compound II with a compound III in the presence of a dehydrating agent such as N,N'-dicyclohexylcarbodiimide, etc., at room temperature-150°C, optionally in the presence of a solvent such as THF.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10236278A JPS5528955A (en) | 1978-08-24 | 1978-08-24 | Novel glycerophosphoric acid derivative, its salt, their preparation, and carcinostatic agent containing the same. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10236278A JPS5528955A (en) | 1978-08-24 | 1978-08-24 | Novel glycerophosphoric acid derivative, its salt, their preparation, and carcinostatic agent containing the same. |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10475586A Division JPS6294A (en) | 1986-05-09 | 1986-05-09 | Novel glycerophosphoric acid derivative and salt and production thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5528955A true JPS5528955A (en) | 1980-02-29 |
JPS6338322B2 JPS6338322B2 (en) | 1988-07-29 |
Family
ID=14325340
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10236278A Granted JPS5528955A (en) | 1978-08-24 | 1978-08-24 | Novel glycerophosphoric acid derivative, its salt, their preparation, and carcinostatic agent containing the same. |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5528955A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2511004A1 (en) * | 1981-08-08 | 1983-02-11 | Roehm Gmbh | PROCESS FOR THE PREPARATION OF PHYSIOLOGICAL EFFECTORS OF THE 1-0-ALCOYL-2-ACETYL-3-PHOSPHORYLCHOLINE-SN-GLYCERINE TYPE, COMPOUNDS OBTAINED AND THEIR APPLICATIONS |
EP0184905A1 (en) * | 1984-11-09 | 1986-06-18 | Takeda Chemical Industries, Ltd. | 2-Acetoacetylglycerol derivatives, their production and use |
US5340568A (en) * | 1992-07-01 | 1994-08-23 | The Procter & Gamble Company | Topical composition and method containing deoxy and halo derivatives of lysophosphatidic acids for regulating skin wrinkles |
US5565439A (en) * | 1992-11-24 | 1996-10-15 | The Procter & Gamble Company | Methods of using lysophosphatidic acid for treating hyperproliferative conditions |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH03135023A (en) * | 1989-10-20 | 1991-06-10 | Tokyo Electron Ltd | Bidirectional treatment apparatus for substrate |
JPH03135022A (en) * | 1989-10-20 | 1991-06-10 | Tokyo Electron Ltd | Treatment apparatus for substrate |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4912662A (en) * | 1972-05-17 | 1974-02-04 | ||
JPS49126624A (en) * | 1973-04-18 | 1974-12-04 | ||
JPS52134027A (en) * | 1976-05-04 | 1977-11-09 | Max Planck Gesellschaft | Antiitumor agent |
JPS552636A (en) * | 1978-06-22 | 1980-01-10 | Toyama Chem Co Ltd | Novel lysolecithin compound and its preparation, and carcinostatics comprising it |
-
1978
- 1978-08-24 JP JP10236278A patent/JPS5528955A/en active Granted
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4912662A (en) * | 1972-05-17 | 1974-02-04 | ||
JPS49126624A (en) * | 1973-04-18 | 1974-12-04 | ||
JPS52134027A (en) * | 1976-05-04 | 1977-11-09 | Max Planck Gesellschaft | Antiitumor agent |
JPS552636A (en) * | 1978-06-22 | 1980-01-10 | Toyama Chem Co Ltd | Novel lysolecithin compound and its preparation, and carcinostatics comprising it |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2511004A1 (en) * | 1981-08-08 | 1983-02-11 | Roehm Gmbh | PROCESS FOR THE PREPARATION OF PHYSIOLOGICAL EFFECTORS OF THE 1-0-ALCOYL-2-ACETYL-3-PHOSPHORYLCHOLINE-SN-GLYCERINE TYPE, COMPOUNDS OBTAINED AND THEIR APPLICATIONS |
EP0184905A1 (en) * | 1984-11-09 | 1986-06-18 | Takeda Chemical Industries, Ltd. | 2-Acetoacetylglycerol derivatives, their production and use |
US4710579A (en) * | 1984-11-09 | 1987-12-01 | Takeda Chemical Industries, Ltd. | 2-(acetoacetyloxy)-3-(octadecyloxy)propyl-3-trimethylammoniopropyl phosphate or a pharmaceutically acceptable salt thereof |
US5340568A (en) * | 1992-07-01 | 1994-08-23 | The Procter & Gamble Company | Topical composition and method containing deoxy and halo derivatives of lysophosphatidic acids for regulating skin wrinkles |
US5565439A (en) * | 1992-11-24 | 1996-10-15 | The Procter & Gamble Company | Methods of using lysophosphatidic acid for treating hyperproliferative conditions |
Also Published As
Publication number | Publication date |
---|---|
JPS6338322B2 (en) | 1988-07-29 |
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