JPS57154169A - Novel 4-oximino-1,2,3,4-tetrahydroquinoline derivative - Google Patents
Novel 4-oximino-1,2,3,4-tetrahydroquinoline derivativeInfo
- Publication number
- JPS57154169A JPS57154169A JP3991181A JP3991181A JPS57154169A JP S57154169 A JPS57154169 A JP S57154169A JP 3991181 A JP3991181 A JP 3991181A JP 3991181 A JP3991181 A JP 3991181A JP S57154169 A JPS57154169 A JP S57154169A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- oximino
- tetrahydroquinoline
- heating
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Quinoline Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:The 4-oximino-1,2,3,4-tetrahydroquinoline derivative of formula (R is alkyl; X is F, Cl or Br).
EXAMPLE: 6-Chloro-4-oximino-1-methoxycarbonyl-1,2,3,4-tetrahydroquinoline.
USE: Medicine. It has strong antihydropic and diuretic activities, and extremely low adverse effect to the digestive organs.
PROCESS: The compound of formulaIis prepared e.g. by (1) heating a p-halogen- substituted aniline and an acrylic acid ester in a solvent, (2) hydrolyzing the resultant compound and heating in the presence of a dehydrating agent to afford a 6-halogen-substituted 4-oxo-1,2,3,4-tetrahydroquinoline, (3) reacting the compound with various chloroformate which can condense the compound to effect the N-alkoxy-carbonylation of the product, and (4) heating the resultant compound in a mixed solvent of pyridine and alcohol in the presence of hydroxylamine hydrochloride.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3991181A JPS57154169A (en) | 1981-03-19 | 1981-03-19 | Novel 4-oximino-1,2,3,4-tetrahydroquinoline derivative |
| US06/281,243 US4421919A (en) | 1980-07-28 | 1981-07-07 | 4-Oximino-1,2,3,4-tetrahydroquinoline derivatives |
| GB8120931A GB2092130B (en) | 1980-07-28 | 1981-07-07 | 4-oximino-1,2,3,4-tetrahydroquinoline derivatives |
| FR8114436A FR2487346A1 (en) | 1980-07-28 | 1981-07-24 | 4-OXIMINO-1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES, PROCESS FOR PREPARING THEM AND THERAPEUTIC APPLICATION THEREOF |
| DE19813129718 DE3129718A1 (en) | 1980-07-28 | 1981-07-28 | 4-OXIMINO-1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3991181A JPS57154169A (en) | 1981-03-19 | 1981-03-19 | Novel 4-oximino-1,2,3,4-tetrahydroquinoline derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS57154169A true JPS57154169A (en) | 1982-09-22 |
| JPS6121629B2 JPS6121629B2 (en) | 1986-05-28 |
Family
ID=12566123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3991181A Granted JPS57154169A (en) | 1980-07-28 | 1981-03-19 | Novel 4-oximino-1,2,3,4-tetrahydroquinoline derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS57154169A (en) |
-
1981
- 1981-03-19 JP JP3991181A patent/JPS57154169A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6121629B2 (en) | 1986-05-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPS57136579A (en) | Thiazolylurea derivative, its preparation, and pharmaceutical composition containing the same | |
| JPS552602A (en) | 1-beta-d-arabinofranosylcytosine-5'-phosphoric acid oleyl ester | |
| JPS5655359A (en) | Halogenated alpha-amino acid, and its preparation | |
| JPS55145665A (en) | Agent for forming active ester of amino acid | |
| JPS57154169A (en) | Novel 4-oximino-1,2,3,4-tetrahydroquinoline derivative | |
| JPS5540628A (en) | Novel hydroxamic acid compound, its preparation, and medicine containing the same | |
| JPS5528955A (en) | Novel glycerophosphoric acid derivative, its salt, their preparation, and carcinostatic agent containing the same. | |
| JPS57154168A (en) | Novel 4-oximino-1,2,3,4-tetrahydroquinoline derivative | |
| JPS57126462A (en) | Novel carboxylic ester and its preparation | |
| JPS56125333A (en) | Phenylacetic acid derivative and its preparation | |
| JPS55154950A (en) | Novel carboxylic acid amide derivative | |
| JPS5645454A (en) | Cyclohexanecarboxylic acid derivative and its preparation | |
| JPS5668672A (en) | Novel 2-acetoxybenzamide derviative, its preparation, and pharmaceutical containing said derviative as effective component | |
| JPS55108883A (en) | Ethyl-(gamma-acetamino-gamma-ethoxycarbonyl-gamma-cyanopropyl- methyl) phosphinate and its preparation | |
| JPS54128584A (en) | Novel 3,4-dihydrocarbostyril derivative | |
| JPS54128523A (en) | 3-guanidinoamino propionic acid and its preparation | |
| JPS54122281A (en) | 5-fluorouracil derivative and its preparation | |
| JPS5579395A (en) | Novel germanium compound | |
| JPS5673064A (en) | Isoquinoline derivative | |
| JPS5363347A (en) | Substd. benzoic acid amide and process for preparing them | |
| JPS55167203A (en) | Herbicide | |
| JPS5461128A (en) | Peptide derivative | |
| JPS5651478A (en) | 3-carbamoyl-pyrazolo 1,5-a pyridine and its preparation | |
| JPS5683478A (en) | 4-halogenomethyl-1-phthalazone derivative, its preparation and preparation of 4-hydroxymethylphthalazone derivative | |
| JPS5210219A (en) | Preparation of beta-sulfonylacrylic beta-sulfonylacrylic their esters and acids their esters and amides |