JPS5683478A - 4-halogenomethyl-1-phthalazone derivative, its preparation and preparation of 4-hydroxymethylphthalazone derivative - Google Patents

4-halogenomethyl-1-phthalazone derivative, its preparation and preparation of 4-hydroxymethylphthalazone derivative

Info

Publication number
JPS5683478A
JPS5683478A JP16087379A JP16087379A JPS5683478A JP S5683478 A JPS5683478 A JP S5683478A JP 16087379 A JP16087379 A JP 16087379A JP 16087379 A JP16087379 A JP 16087379A JP S5683478 A JPS5683478 A JP S5683478A
Authority
JP
Japan
Prior art keywords
formula
preparation
derivative
phthalazone
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP16087379A
Other languages
Japanese (ja)
Inventor
Masao Takei
Masao Yoshida
Rinzo Nishizawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Kayaku Co Ltd
Original Assignee
Nippon Kayaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Kayaku Co Ltd filed Critical Nippon Kayaku Co Ltd
Priority to JP16087379A priority Critical patent/JPS5683478A/en
Priority to CA000356356A priority patent/CA1143733A/en
Priority to GB8023611A priority patent/GB2055825B/en
Priority to AU60691/80A priority patent/AU531727B2/en
Priority to US06/171,363 priority patent/US4350813A/en
Priority to NL8004231A priority patent/NL8004231A/en
Priority to DE19803028369 priority patent/DE3028369A1/en
Priority to IT49362/80A priority patent/IT1147016B/en
Priority to AR281950A priority patent/AR227158A1/en
Priority to CH577580A priority patent/CH645360A5/en
Priority to ES493798A priority patent/ES8106708A1/en
Priority to HU801909A priority patent/HU185378B/en
Priority to FR8016862A priority patent/FR2462429A1/en
Priority to DK328280A priority patent/DK328280A/en
Publication of JPS5683478A publication Critical patent/JPS5683478A/en
Priority to FR8214622A priority patent/FR2510110A1/fr
Priority to FR8214621A priority patent/FR2510109A1/en
Priority to CA000413865A priority patent/CA1151648A/en
Priority to CA000413866A priority patent/CA1151659A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:A 6, 8-dimethyl-7-alkoxycarbonyl-4-halogenomethyl-1-phthalazone of formula I (R1 is lower alkyl; R3 is cyano or carbamoyl; X is halogen).
EXAMPLE: 4-Cyanomethyl-6,8-dimethyl-7-ethoxycarbonyl-1-phthalazone.
USE: A synthetic intermediate for an ester of 4-hydroxymethyl-6,8-dimethyl-1-phthalazone-7-carboxylic acid which is useful as a remedy for cerebral hemorrhage and thrombosis, etc.
PROCESS: A 3,5-dimethyl-4-alkoxycarbonylphthalic acid anhydride is reacted with cyanomethylenetriphenylphosphorane to give a compound of formula III, which is then reacted with hydrazine to form a compound of formula IV. The compound of formula IV is hydrolyzed to give a compound of formula V, which is then halogenated to afford the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP16087379A 1979-07-31 1979-12-13 4-halogenomethyl-1-phthalazone derivative, its preparation and preparation of 4-hydroxymethylphthalazone derivative Pending JPS5683478A (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
JP16087379A JPS5683478A (en) 1979-12-13 1979-12-13 4-halogenomethyl-1-phthalazone derivative, its preparation and preparation of 4-hydroxymethylphthalazone derivative
CA000356356A CA1143733A (en) 1979-07-31 1980-07-16 Producing 7-alkoxycarbonyl-6,8-dimethyl-4- hydroxymethyl-1-phthalazone and intermediates
GB8023611A GB2055825B (en) 1979-07-31 1980-07-18 Process for producing 7-alkoxycarbonyl-6,8-dimethyl-4-hydroxymethyl-1-phthalazone
AU60691/80A AU531727B2 (en) 1979-07-31 1980-07-22 Phthalazone derivatives
US06/171,363 US4350813A (en) 1979-07-31 1980-07-23 Process for producing 7-alkoxycarbonyl-6,8-dimethyl-4-hydroxymethyl-1-phthalazone and its intermediates
NL8004231A NL8004231A (en) 1979-07-31 1980-07-23 PROCESS FOR PREPARING 7-ALKOXYCARBONYL-6, 8-DIMETHYL-4-HYDROXYMETHYL-1-PHTHALAZONE AND INTERMEDIATES THEREOF.
DE19803028369 DE3028369A1 (en) 1979-07-31 1980-07-26 METHOD FOR PRODUCING 7-ALKOXYCARBONYL-6,8-DIMETHYL-4-HYDROXYMETHYL-1-PHTHALAZONE AND THE INTERMEDIATE PRODUCTS THEREOF
IT49362/80A IT1147016B (en) 1979-07-31 1980-07-28 PROCEDURE FOR THE PRODUCTION OF 7-ALCOXYCARBONYL-6,8-DIMETHYL-4-HYDROXYMETHYL-1-PHTHALAZONE AND RELATED INTERMEDIATE PRODUCTS
AR281950A AR227158A1 (en) 1979-07-31 1980-07-28 NEW DERIVATIVES OF 4,6,8-TRIMETIL-7-ALCOXI-CARBONIL-1-FTALAZONA, USEFUL AS INTERMEDIARIES TO OBTAIN COMPOUNDS OF 6,8-DIMETIL-4-HIDROXIMETIL-1-FTALAZONA AND PROCEDURE TO OBTAIN THESE COMPOUNDS
CH577580A CH645360A5 (en) 1979-07-31 1980-07-29 METHOD FOR PRODUCING 7-ALKOXYCARBONYL-6,8-DIMETHYL-4-HYDROXYMETHYL-1-PHTHALAZONE.
ES493798A ES8106708A1 (en) 1979-07-31 1980-07-29 Process for producing 7-alkoxycarbonyl-6,8-dimethyl-4-hydroxymethyl-1-phthalazone and its intermediates
HU801909A HU185378B (en) 1979-07-31 1980-07-30 Process for producing 7-alkoxy-carbonyl-6,8-dimethyl-4-hydroxy-methyl-1-phtalazones
FR8016862A FR2462429A1 (en) 1979-07-31 1980-07-30 PROCESS FOR THE PREPARATION OF 7-ALCOXYCARBONYL-6,8-DIMETHYL-4-HYDROXYMETHYL-1-PHTALAZONES AND THEIR INTERMEDIATES AND PRODUCTS THUS OBTAINED
DK328280A DK328280A (en) 1979-07-31 1980-07-30 PROCEDURE FOR THE PREPARATION OF 7-ALCOXYCARBONYL-6,8-DIMETHYL-4-HYDROXYMETHYL-1-PHTHALAZONE AND INTERMEDIATES
FR8214622A FR2510110A1 (en) 1979-07-31 1982-08-25
FR8214621A FR2510109A1 (en) 1979-07-31 1982-08-25 7-ALCOXYCARBONYL-6,8-DIMETHYL-1-PHTHALAZONE-4-A-HYDROXYACETIC ACID AND PROCESS FOR PREPARING THE SAME
CA000413865A CA1151648A (en) 1979-07-31 1982-10-20 Producing 7-alkoxycarbonyl-6,8-dimethyl-4- hydroxymethyl-1-phthalazone and intermediates
CA000413866A CA1151659A (en) 1979-07-31 1982-10-20 Producing 7-alkoxycarbonyl-6,8-dimethyl-4- hydroxymethyl-1-phthalazone and intermediates

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP16087379A JPS5683478A (en) 1979-12-13 1979-12-13 4-halogenomethyl-1-phthalazone derivative, its preparation and preparation of 4-hydroxymethylphthalazone derivative

Publications (1)

Publication Number Publication Date
JPS5683478A true JPS5683478A (en) 1981-07-08

Family

ID=15724207

Family Applications (1)

Application Number Title Priority Date Filing Date
JP16087379A Pending JPS5683478A (en) 1979-07-31 1979-12-13 4-halogenomethyl-1-phthalazone derivative, its preparation and preparation of 4-hydroxymethylphthalazone derivative

Country Status (1)

Country Link
JP (1) JPS5683478A (en)

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