JPS5278848A - Preparation of novel propionic acid ester derivatives - Google Patents

Preparation of novel propionic acid ester derivatives

Info

Publication number
JPS5278848A
JPS5278848A JP50156799A JP15679975A JPS5278848A JP S5278848 A JPS5278848 A JP S5278848A JP 50156799 A JP50156799 A JP 50156799A JP 15679975 A JP15679975 A JP 15679975A JP S5278848 A JPS5278848 A JP S5278848A
Authority
JP
Japan
Prior art keywords
propionic acid
acid ester
ester derivatives
preparation
novel propionic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP50156799A
Other versions
JPS5826744B2 (en
Inventor
Hiroyuki Ide
Yuji Ishikura
Akira Nakagawa
Kanji Noda
Original Assignee
Hisamitsu Pharmaceut Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hisamitsu Pharmaceut Co Inc filed Critical Hisamitsu Pharmaceut Co Inc
Priority to JP50156799A priority Critical patent/JPS5826744B2/ja
Publication of JPS5278848A publication Critical patent/JPS5278848A/en
Priority claimed from US05/845,237 external-priority patent/US4150137A/en
Publication of JPS5826744B2 publication Critical patent/JPS5826744B2/ja
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28Radicals substituted by singly-bound oxygen or sulfur atoms
    • C07D213/30Oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/612Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with heteroatoms or with carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61Halogen atoms or nitro radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/12Radicals substituted by oxygen atoms

Abstract

PURPOSE: Propionic acid ester derivatives of formula I(R is lower alkyl, substd. alkyl, 3-p-menthanyl);for example, 2-(p-isobutylphenyl) propionic acid-l-menthyl ester.
COPYRIGHT: (C)1977,JPO&Japio
JP50156799A 1975-12-24 1975-12-24 Expired JPS5826744B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP50156799A JPS5826744B2 (en) 1975-12-24 1975-12-24

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
JP50156799A JPS5826744B2 (en) 1975-12-24 1975-12-24
SE7613651A SE433492B (en) 1975-12-24 1976-12-06 Seen to be stella fenylettiksyraderivat
CA267,690A CA1076134A (en) 1975-12-24 1976-12-13 Process for preparing phenylacetic acid ester derivatives
CH1607276A CH617919A5 (en) 1975-12-24 1976-12-21 Process for the preparation of new derivatives of esters of phenyl-acetic acid
FR7638482A FR2336126B1 (en) 1975-12-24 1976-12-21
DE2658610A DE2658610C2 (en) 1975-12-24 1976-12-23
NLAANVRAGE7614308,A NL180381C (en) 1975-12-24 1976-12-23 Method for preparing a 2- (4-isobutylphenyl) propionic acid ester containing medicinal product and method for preparing the medicinal compounds
AU20878/76A AU507661B2 (en) 1975-12-24 1976-12-23 Phenylacetic acid ester derivatives
GB51350/76A GB1573322A (en) 1975-12-24 1976-12-24 Phenylactic acid ester derivatives
US05/845,237 US4150137A (en) 1975-12-24 1977-10-25 Pyridylalkyl esters of 2-(p-isobutylphenyl)acetic acid and propionic acids and use

Publications (2)

Publication Number Publication Date
JPS5278848A true JPS5278848A (en) 1977-07-02
JPS5826744B2 JPS5826744B2 (en) 1983-06-04

Family

ID=15635562

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50156799A Expired JPS5826744B2 (en) 1975-12-24 1975-12-24

Country Status (9)

Country Link
JP (1) JPS5826744B2 (en)
AU (1) AU507661B2 (en)
CA (1) CA1076134A (en)
CH (1) CH617919A5 (en)
DE (1) DE2658610C2 (en)
FR (1) FR2336126B1 (en)
GB (1) GB1573322A (en)
NL (1) NL180381C (en)
SE (1) SE433492B (en)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54144336A (en) * 1978-07-24 1979-11-10 Teikoku Seiyaku Kk Propionic acid propylester derivative*its manufacture and antiiinflammatory and sedative agent containing it
JPS5517358A (en) * 1978-07-24 1980-02-06 Teikoku Seiyaku Kk Butyl propionate derivative, its preparation, and antiphlogistic and analgesic comprising it
JPS5587770A (en) * 1978-12-27 1980-07-02 Hisamitsu Pharmaceut Co Inc Preparation of 2-(p-isobutylphenyl)propionic acid 2-pyridinemethyl ester
JPS57203035A (en) * 1981-06-05 1982-12-13 Taisho Pharmaceut Co Ltd Carboxylic acid ester
JPS62413A (en) * 1985-06-27 1987-01-06 Hisamitsu Pharmaceut Co Inc Cosmetic
JPH02130A (en) * 1989-04-10 1990-01-05 Eisai Co Ltd Polyprenyl-based compound, production thereof and medicine containing the same compound
JP2015120703A (en) * 2015-01-05 2015-07-02 テックフィールズ インコーポレイテッド Nsaia prodrug having very fast skin- and film-infiltration rate, and new use thereof as medicine
JP2017523973A (en) * 2014-08-07 2017-08-24 富力 Filigenin ibuprofen ester, its preparation method and its application
US10233198B2 (en) 2007-06-04 2019-03-19 Techfields Pharma Co., Ltd. Pro-drugs of NSAIAs with very high skin and membranes penetration rates and their new medicinal uses
US10378806B2 (en) 2012-12-13 2019-08-13 Whirlpool Corporation Clear ice maker
US10605512B2 (en) 2012-12-13 2020-03-31 Whirlpool Corporation Method of warming a mold apparatus
US10690388B2 (en) 2014-10-23 2020-06-23 Whirlpool Corporation Method and apparatus for increasing rate of ice production in an automatic ice maker

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3225290C2 (en) * 1982-07-07 1993-09-16 Merck Patent Gmbh, 64293 Darmstadt, De
YU43408B (en) * 1985-04-26 1989-06-30 Lek Tovarna Farmacevtskih Process for preparation of 2-(4-isobuthylphenyl)-prophiohydroxamic acid
ES2004447A6 (en) * 1987-07-06 1989-01-01 Sune Coma Nuria New 2-(P-isobutylphenyl)-propionic acid ester and process for the preparation thereof.
DE3811118C1 (en) * 1988-03-31 1989-10-12 Merckle Gmbh, 7902 Blaubeuren, De
IT1217589B (en) * 1988-05-13 1990-03-30 Pulitzer Italiana anti-inflammatory agent for the therapy of prostatic hypertrophy, its preparation and related pharmaceutical compositions
HU219242B (en) 1991-05-13 2001-03-28 Boots Co Plc S(+)-ibuprofen sodium salt dihydrate, pharmaceutical composition comprising this compound and process for production of them
US6399618B1 (en) * 1997-07-09 2002-06-04 Cardiome Pharma Corp Compositions and methods for modulating sexual activity
CN103948571A (en) * 2006-07-18 2014-07-30 天津昕晨泰飞尔医药科技有限公司 Water-soluble ibuprofen prodrug with high skin penetration rate and positive charge
EP2773378B1 (en) * 2011-10-31 2016-08-10 Larsen, Claus Selch Prodrugs of non-steroid anti-inflammatory agents (nsaids)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3124M (en) * 1961-02-02

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54144336A (en) * 1978-07-24 1979-11-10 Teikoku Seiyaku Kk Propionic acid propylester derivative*its manufacture and antiiinflammatory and sedative agent containing it
JPS5517358A (en) * 1978-07-24 1980-02-06 Teikoku Seiyaku Kk Butyl propionate derivative, its preparation, and antiphlogistic and analgesic comprising it
JPS5587770A (en) * 1978-12-27 1980-07-02 Hisamitsu Pharmaceut Co Inc Preparation of 2-(p-isobutylphenyl)propionic acid 2-pyridinemethyl ester
JPS5742627B2 (en) * 1978-12-27 1982-09-09
JPS57203035A (en) * 1981-06-05 1982-12-13 Taisho Pharmaceut Co Ltd Carboxylic acid ester
JPS62413A (en) * 1985-06-27 1987-01-06 Hisamitsu Pharmaceut Co Inc Cosmetic
JPH02130A (en) * 1989-04-10 1990-01-05 Eisai Co Ltd Polyprenyl-based compound, production thereof and medicine containing the same compound
US10233198B2 (en) 2007-06-04 2019-03-19 Techfields Pharma Co., Ltd. Pro-drugs of NSAIAs with very high skin and membranes penetration rates and their new medicinal uses
US10378806B2 (en) 2012-12-13 2019-08-13 Whirlpool Corporation Clear ice maker
US10605512B2 (en) 2012-12-13 2020-03-31 Whirlpool Corporation Method of warming a mold apparatus
JP2017523973A (en) * 2014-08-07 2017-08-24 富力 Filigenin ibuprofen ester, its preparation method and its application
US10690388B2 (en) 2014-10-23 2020-06-23 Whirlpool Corporation Method and apparatus for increasing rate of ice production in an automatic ice maker
JP2015120703A (en) * 2015-01-05 2015-07-02 テックフィールズ インコーポレイテッド Nsaia prodrug having very fast skin- and film-infiltration rate, and new use thereof as medicine

Also Published As

Publication number Publication date
SE7613651L (en) 1977-06-25
JPS5826744B2 (en) 1983-06-04
NL180381C (en) 1987-02-16
CA1076134A1 (en)
DE2658610A1 (en) 1977-07-07
CH617919A5 (en) 1980-06-30
FR2336126B1 (en) 1979-03-09
GB1573322A (en) 1980-08-20
NL180381B (en) 1986-09-16
AU507661B2 (en) 1980-02-21
NL7614308A (en) 1977-06-28
DE2658610C2 (en) 1982-12-23
SE433492B (en) 1984-05-28
FR2336126A1 (en) 1977-07-22
CA1076134A (en) 1980-04-22
AU2087876A (en) 1978-06-29

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