JPS5636464A - Phthalazone-4-halogenoacetic acid derivative, its preparation and production of 4-hydroxymethylphthalazone derivative - Google Patents

Phthalazone-4-halogenoacetic acid derivative, its preparation and production of 4-hydroxymethylphthalazone derivative

Info

Publication number
JPS5636464A
JPS5636464A JP9676379A JP9676379A JPS5636464A JP S5636464 A JPS5636464 A JP S5636464A JP 9676379 A JP9676379 A JP 9676379A JP 9676379 A JP9676379 A JP 9676379A JP S5636464 A JPS5636464 A JP S5636464A
Authority
JP
Japan
Prior art keywords
phthalazone
formula
dimethyl
derivative
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9676379A
Other languages
Japanese (ja)
Inventor
Masao Takei
Masao Yoshida
Rinzo Nishizawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Kayaku Co Ltd
Original Assignee
Nippon Kayaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Kayaku Co Ltd filed Critical Nippon Kayaku Co Ltd
Priority to JP9676379A priority Critical patent/JPS5636464A/en
Priority to CA000356356A priority patent/CA1143733A/en
Priority to GB8023611A priority patent/GB2055825B/en
Priority to AU60691/80A priority patent/AU531727B2/en
Priority to US06/171,363 priority patent/US4350813A/en
Priority to NL8004231A priority patent/NL8004231A/en
Priority to DE19803028369 priority patent/DE3028369A1/en
Priority to IT49362/80A priority patent/IT1147016B/en
Priority to AR281950A priority patent/AR227158A1/en
Priority to CH577580A priority patent/CH645360A5/en
Priority to ES493798A priority patent/ES8106708A1/en
Priority to HU801909A priority patent/HU185378B/en
Priority to FR8016862A priority patent/FR2462429A1/en
Priority to DK328280A priority patent/DK328280A/en
Publication of JPS5636464A publication Critical patent/JPS5636464A/en
Priority to US06/386,001 priority patent/US4464532A/en
Priority to FR8214622A priority patent/FR2510110A1/fr
Priority to FR8214621A priority patent/FR2510109A1/en
Priority to CA000413865A priority patent/CA1151648A/en
Priority to CA000413866A priority patent/CA1151659A/en
Pending legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

NEW MATERIAL:6, 8-Dimethyl-7-alkoxycarbonyl-1-phthalazone-4-α-halogenoacetic acid of formula I (R1 is lower alkyl; X is halogen).
EXAMPLE: 6,8-Dimethyl-7-ethoxycarbonyl-1-phthalazone-4-α-bromoacetic acid.
USE: A synthetic intermediate of 4-hydroxymethyl-6,8-dimethyl-1-phthalazone-7- carboxylic ester which is used as a remedy for cerebral hemorrhage, cerebral thrombosis, pultaceous sclerosis, because they have strong blood platelet coagulation inhibition activity and phosphodiesterase inhibition activity.
PREPARATION: The reaction of 3,5-dimethyl-4-alkoxycarbonylphthalic acid anhydride of formula II (R is lower alkyl) with a compound of formula III (R3 is lower alkyl) affords a compound of formula IV, which is made to react with hydrazine. The product is hydrolyzed and halogenated to give the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP9676379A 1979-07-31 1979-07-31 Phthalazone-4-halogenoacetic acid derivative, its preparation and production of 4-hydroxymethylphthalazone derivative Pending JPS5636464A (en)

Priority Applications (19)

Application Number Priority Date Filing Date Title
JP9676379A JPS5636464A (en) 1979-07-31 1979-07-31 Phthalazone-4-halogenoacetic acid derivative, its preparation and production of 4-hydroxymethylphthalazone derivative
CA000356356A CA1143733A (en) 1979-07-31 1980-07-16 Producing 7-alkoxycarbonyl-6,8-dimethyl-4- hydroxymethyl-1-phthalazone and intermediates
GB8023611A GB2055825B (en) 1979-07-31 1980-07-18 Process for producing 7-alkoxycarbonyl-6,8-dimethyl-4-hydroxymethyl-1-phthalazone
AU60691/80A AU531727B2 (en) 1979-07-31 1980-07-22 Phthalazone derivatives
US06/171,363 US4350813A (en) 1979-07-31 1980-07-23 Process for producing 7-alkoxycarbonyl-6,8-dimethyl-4-hydroxymethyl-1-phthalazone and its intermediates
NL8004231A NL8004231A (en) 1979-07-31 1980-07-23 PROCESS FOR PREPARING 7-ALKOXYCARBONYL-6, 8-DIMETHYL-4-HYDROXYMETHYL-1-PHTHALAZONE AND INTERMEDIATES THEREOF.
DE19803028369 DE3028369A1 (en) 1979-07-31 1980-07-26 METHOD FOR PRODUCING 7-ALKOXYCARBONYL-6,8-DIMETHYL-4-HYDROXYMETHYL-1-PHTHALAZONE AND THE INTERMEDIATE PRODUCTS THEREOF
IT49362/80A IT1147016B (en) 1979-07-31 1980-07-28 PROCEDURE FOR THE PRODUCTION OF 7-ALCOXYCARBONYL-6,8-DIMETHYL-4-HYDROXYMETHYL-1-PHTHALAZONE AND RELATED INTERMEDIATE PRODUCTS
AR281950A AR227158A1 (en) 1979-07-31 1980-07-28 NEW DERIVATIVES OF 4,6,8-TRIMETIL-7-ALCOXI-CARBONIL-1-FTALAZONA, USEFUL AS INTERMEDIARIES TO OBTAIN COMPOUNDS OF 6,8-DIMETIL-4-HIDROXIMETIL-1-FTALAZONA AND PROCEDURE TO OBTAIN THESE COMPOUNDS
CH577580A CH645360A5 (en) 1979-07-31 1980-07-29 METHOD FOR PRODUCING 7-ALKOXYCARBONYL-6,8-DIMETHYL-4-HYDROXYMETHYL-1-PHTHALAZONE.
ES493798A ES8106708A1 (en) 1979-07-31 1980-07-29 Process for producing 7-alkoxycarbonyl-6,8-dimethyl-4-hydroxymethyl-1-phthalazone and its intermediates
HU801909A HU185378B (en) 1979-07-31 1980-07-30 Process for producing 7-alkoxy-carbonyl-6,8-dimethyl-4-hydroxy-methyl-1-phtalazones
FR8016862A FR2462429A1 (en) 1979-07-31 1980-07-30 PROCESS FOR THE PREPARATION OF 7-ALCOXYCARBONYL-6,8-DIMETHYL-4-HYDROXYMETHYL-1-PHTALAZONES AND THEIR INTERMEDIATES AND PRODUCTS THUS OBTAINED
DK328280A DK328280A (en) 1979-07-31 1980-07-30 PROCEDURE FOR THE PREPARATION OF 7-ALCOXYCARBONYL-6,8-DIMETHYL-4-HYDROXYMETHYL-1-PHTHALAZONE AND INTERMEDIATES
US06/386,001 US4464532A (en) 1979-07-31 1982-06-07 Intermediates of 7-alkoxycarbonyl-6,8-dimethyl-4-hydroxymethyl-1-phthalazone
FR8214622A FR2510110A1 (en) 1979-07-31 1982-08-25
FR8214621A FR2510109A1 (en) 1979-07-31 1982-08-25 7-ALCOXYCARBONYL-6,8-DIMETHYL-1-PHTHALAZONE-4-A-HYDROXYACETIC ACID AND PROCESS FOR PREPARING THE SAME
CA000413865A CA1151648A (en) 1979-07-31 1982-10-20 Producing 7-alkoxycarbonyl-6,8-dimethyl-4- hydroxymethyl-1-phthalazone and intermediates
CA000413866A CA1151659A (en) 1979-07-31 1982-10-20 Producing 7-alkoxycarbonyl-6,8-dimethyl-4- hydroxymethyl-1-phthalazone and intermediates

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9676379A JPS5636464A (en) 1979-07-31 1979-07-31 Phthalazone-4-halogenoacetic acid derivative, its preparation and production of 4-hydroxymethylphthalazone derivative

Publications (1)

Publication Number Publication Date
JPS5636464A true JPS5636464A (en) 1981-04-09

Family

ID=14173668

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9676379A Pending JPS5636464A (en) 1979-07-31 1979-07-31 Phthalazone-4-halogenoacetic acid derivative, its preparation and production of 4-hydroxymethylphthalazone derivative

Country Status (1)

Country Link
JP (1) JPS5636464A (en)

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