JPS5679675A - Production of 2-halogeno-3-substituted 3,4- dihydroquinazoline - Google Patents
Production of 2-halogeno-3-substituted 3,4- dihydroquinazolineInfo
- Publication number
- JPS5679675A JPS5679675A JP15646979A JP15646979A JPS5679675A JP S5679675 A JPS5679675 A JP S5679675A JP 15646979 A JP15646979 A JP 15646979A JP 15646979 A JP15646979 A JP 15646979A JP S5679675 A JPS5679675 A JP S5679675A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- halogeno
- halogen
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: The reaction of a 2-halogeno-3,4-dihydroxyquinazoline with an α-halogeno-fatty acid ester is effected in the presence of an acid acceptor to produce the titled compound, with α-lower alkoxycarbonylalkyl as a 3-substituent readily.
CONSTITUTION: The reaction of a compound of formula I (R1, R2 are H, lower alkyl, lower alkoxy, halogen; X1 is halogen) with another compound of formula II (R3 is H, lower alkyl; R4 is lower alkyl; X2 is halogen) is carried out in the presence of an acid acceptor such as potassium carbonate or sodium carbonate to produce the compound of formula III. The reaction is effected in an inert solvent such as acetone or methyl ethyl ketone under reflux for several to 20hr.
USE: A synthetic intermediate of a compound of formula IV, which has excellent activity of blood platelet coagulation inhibition.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15646979A JPS5679675A (en) | 1979-12-03 | 1979-12-03 | Production of 2-halogeno-3-substituted 3,4- dihydroquinazoline |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15646979A JPS5679675A (en) | 1979-12-03 | 1979-12-03 | Production of 2-halogeno-3-substituted 3,4- dihydroquinazoline |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5679675A true JPS5679675A (en) | 1981-06-30 |
Family
ID=15628421
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15646979A Pending JPS5679675A (en) | 1979-12-03 | 1979-12-03 | Production of 2-halogeno-3-substituted 3,4- dihydroquinazoline |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5679675A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104119344A (en) * | 2014-05-30 | 2014-10-29 | 上海天慈生物谷生物工程有限公司 | Novel method for preparing 6,7-dichloro-1,5-imidazolinyl [2,1-b] quinazoline-2-(3H)-one |
-
1979
- 1979-12-03 JP JP15646979A patent/JPS5679675A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104119344A (en) * | 2014-05-30 | 2014-10-29 | 上海天慈生物谷生物工程有限公司 | Novel method for preparing 6,7-dichloro-1,5-imidazolinyl [2,1-b] quinazoline-2-(3H)-one |
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