JPS56110664A - Guanidinobenzoate and anticomplementary agent - Google Patents

Guanidinobenzoate and anticomplementary agent

Info

Publication number
JPS56110664A
JPS56110664A JP1388080A JP1388080A JPS56110664A JP S56110664 A JPS56110664 A JP S56110664A JP 1388080 A JP1388080 A JP 1388080A JP 1388080 A JP1388080 A JP 1388080A JP S56110664 A JPS56110664 A JP S56110664A
Authority
JP
Japan
Prior art keywords
formula
agent
compound
guanidinobenzoate
anticomplementary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP1388080A
Other languages
Japanese (ja)
Inventor
Setsuo Fujii
Masateru Kurumi
Yojiro Sakurai
Toyoo Nakayama
Ryoji Matsui
Toshiyuki Okutome
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Torii Pharmaceutical Co Ltd
Original Assignee
Torii Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Torii Pharmaceutical Co Ltd filed Critical Torii Pharmaceutical Co Ltd
Priority to JP1388080A priority Critical patent/JPS56110664A/en
Publication of JPS56110664A publication Critical patent/JPS56110664A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:4'-Amidinophenyl 4-guanidinobenzoate of formula I and its pharmaceutically acceptable acid addition salt.
USE: An anticomplementary agent and an antienzyme, having strong inhibiting activity to the enzymes such as trypsin, plasmin, kallikrein, thrombin, etc. It also exhibits C1 esterase-inhibiting activity and anticomplement activity, and is effective to allergic diseases affected by complement, e.g. nephritis.
PROCESS: The compound of formula I is prepared by reacting a compound of formula II (X is halogen) with a compound of formula III. The reaction is carried out in a solvent such as DMF, in the presence of a dehalogenating agent such as pottasium carbonate, pref. at -30W+80°C.
COPYRIGHT: (C)1981,JPO&Japio
JP1388080A 1980-02-07 1980-02-07 Guanidinobenzoate and anticomplementary agent Pending JPS56110664A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP1388080A JPS56110664A (en) 1980-02-07 1980-02-07 Guanidinobenzoate and anticomplementary agent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1388080A JPS56110664A (en) 1980-02-07 1980-02-07 Guanidinobenzoate and anticomplementary agent

Publications (1)

Publication Number Publication Date
JPS56110664A true JPS56110664A (en) 1981-09-01

Family

ID=11845516

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1388080A Pending JPS56110664A (en) 1980-02-07 1980-02-07 Guanidinobenzoate and anticomplementary agent

Country Status (1)

Country Link
JP (1) JPS56110664A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4496584A (en) * 1981-04-28 1985-01-29 Torii & Co. Ltd. Amidine derivatives with anti-complement activity
US4514416A (en) * 1981-02-27 1985-04-30 Torii & Co. Ltd. Amidine compound, process for producing same and anti-complement agent comprising same
US6388122B1 (en) 1996-04-10 2002-05-14 Ono Pharmaceutical Co., Ltd. Tryptase inhibitor and novel guanidino derivatives

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4514416A (en) * 1981-02-27 1985-04-30 Torii & Co. Ltd. Amidine compound, process for producing same and anti-complement agent comprising same
US4570006A (en) * 1981-02-27 1986-02-11 Torii & Co. Ltd. Amidine compound, process for producing same and anti-complement agent comprising same
US4496584A (en) * 1981-04-28 1985-01-29 Torii & Co. Ltd. Amidine derivatives with anti-complement activity
US6388122B1 (en) 1996-04-10 2002-05-14 Ono Pharmaceutical Co., Ltd. Tryptase inhibitor and novel guanidino derivatives

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