JPS56110664A - Guanidinobenzoate and anticomplementary agent - Google Patents
Guanidinobenzoate and anticomplementary agentInfo
- Publication number
- JPS56110664A JPS56110664A JP1388080A JP1388080A JPS56110664A JP S56110664 A JPS56110664 A JP S56110664A JP 1388080 A JP1388080 A JP 1388080A JP 1388080 A JP1388080 A JP 1388080A JP S56110664 A JPS56110664 A JP S56110664A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- agent
- compound
- guanidinobenzoate
- anticomplementary
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:4'-Amidinophenyl 4-guanidinobenzoate of formula I and its pharmaceutically acceptable acid addition salt.
USE: An anticomplementary agent and an antienzyme, having strong inhibiting activity to the enzymes such as trypsin, plasmin, kallikrein, thrombin, etc. It also exhibits C1 esterase-inhibiting activity and anticomplement activity, and is effective to allergic diseases affected by complement, e.g. nephritis.
PROCESS: The compound of formula I is prepared by reacting a compound of formula II (X is halogen) with a compound of formula III. The reaction is carried out in a solvent such as DMF, in the presence of a dehalogenating agent such as pottasium carbonate, pref. at -30W+80°C.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1388080A JPS56110664A (en) | 1980-02-07 | 1980-02-07 | Guanidinobenzoate and anticomplementary agent |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1388080A JPS56110664A (en) | 1980-02-07 | 1980-02-07 | Guanidinobenzoate and anticomplementary agent |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS56110664A true JPS56110664A (en) | 1981-09-01 |
Family
ID=11845516
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1388080A Pending JPS56110664A (en) | 1980-02-07 | 1980-02-07 | Guanidinobenzoate and anticomplementary agent |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56110664A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4496584A (en) * | 1981-04-28 | 1985-01-29 | Torii & Co. Ltd. | Amidine derivatives with anti-complement activity |
US4514416A (en) * | 1981-02-27 | 1985-04-30 | Torii & Co. Ltd. | Amidine compound, process for producing same and anti-complement agent comprising same |
US6388122B1 (en) | 1996-04-10 | 2002-05-14 | Ono Pharmaceutical Co., Ltd. | Tryptase inhibitor and novel guanidino derivatives |
-
1980
- 1980-02-07 JP JP1388080A patent/JPS56110664A/en active Pending
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4514416A (en) * | 1981-02-27 | 1985-04-30 | Torii & Co. Ltd. | Amidine compound, process for producing same and anti-complement agent comprising same |
US4570006A (en) * | 1981-02-27 | 1986-02-11 | Torii & Co. Ltd. | Amidine compound, process for producing same and anti-complement agent comprising same |
US4496584A (en) * | 1981-04-28 | 1985-01-29 | Torii & Co. Ltd. | Amidine derivatives with anti-complement activity |
US6388122B1 (en) | 1996-04-10 | 2002-05-14 | Ono Pharmaceutical Co., Ltd. | Tryptase inhibitor and novel guanidino derivatives |
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