JPS5645454A - Cyclohexanecarboxylic acid derivative and its preparation - Google Patents

Cyclohexanecarboxylic acid derivative and its preparation

Info

Publication number
JPS5645454A
JPS5645454A JP12014279A JP12014279A JPS5645454A JP S5645454 A JPS5645454 A JP S5645454A JP 12014279 A JP12014279 A JP 12014279A JP 12014279 A JP12014279 A JP 12014279A JP S5645454 A JPS5645454 A JP S5645454A
Authority
JP
Japan
Prior art keywords
formula
compound
reaction
cyclohexanecarboxylic acid
acid derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12014279A
Other languages
Japanese (ja)
Other versions
JPS6324988B2 (en
Inventor
Mutsumi Muramatsu
Toshio Sato
Yukio Yanagimoto
Tadami Shinnai
Toshio Nakajima
Isao Nakajima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Chemiphar Co Ltd
Aska Pharmaceutical Co Ltd
Teikoku Chemical Industry Co Ltd
Original Assignee
Nippon Chemiphar Co Ltd
Teikoku Chemical Industry Co Ltd
Teikoku Hormone Manufacturing Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Chemiphar Co Ltd, Teikoku Chemical Industry Co Ltd, Teikoku Hormone Manufacturing Co Ltd filed Critical Nippon Chemiphar Co Ltd
Priority to JP12014279A priority Critical patent/JPS5645454A/en
Priority to SE8006365A priority patent/SE460667B/en
Priority to AU62320/80A priority patent/AU541738B2/en
Priority to US06/186,849 priority patent/US4348410A/en
Priority to DE19803035086 priority patent/DE3035086A1/en
Priority to BE0/202125A priority patent/BE885263A/en
Priority to GB8030183A priority patent/GB2058773B/en
Priority to ES495175A priority patent/ES8200643A1/en
Priority to CH706480A priority patent/CH646687A5/en
Priority to DK396880A priority patent/DK163580C/en
Priority to FR8020263A priority patent/FR2472561B1/en
Priority to NL8005238A priority patent/NL8005238A/en
Priority to AT0470680A priority patent/AT375918B/en
Priority to IT68457/80A priority patent/IT1129264B/en
Priority to HU230880A priority patent/HU184828B/en
Priority to PH24606A priority patent/PH17322A/en
Priority to AR282590A priority patent/AR227525A1/en
Priority to CA000360655A priority patent/CA1142943A/en
Priority to IN1071/CAL/80A priority patent/IN151297B/en
Priority to MX867180A priority patent/MX155236A/en
Priority to BR8006052A priority patent/BR8006052A/en
Publication of JPS5645454A publication Critical patent/JPS5645454A/en
Priority to IN1514/CAL/82A priority patent/IN155437B/en
Publication of JPS6324988B2 publication Critical patent/JPS6324988B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Abstract

NEW MATERIAL:A cyclohexanecarboxylic acid derivative of formula I [R is (un)substituted phenyl] and a nontoxic salt thereof.
EXAMPLE: Phenyl trans-4-guanidinomethylcyclohexanecarboxylate hydrochloride.
USE: Useful as a medicine having improved inhibitory action on proteolytic enzymes
PROCESS: A compound of formula II or a reactive derivative thereof, e.g. an acid halide is reacted with a phenol of formula III to give the titled compound of formula I. In case the compound of formula II is directly used, the reaction is carried out in an organic solvent, e.g. DMF, at room temperature to the reflux temperature for 5W30hr. A condensing agent used for the ester synthesis is preferably present in the reaction system. In case the reactive derivative of formula II is used, the reaction is carried out in an organic solvent, e.g. dichloroethane, at room temperature to the reflux temperature for 1W5hr.
COPYRIGHT: (C)1981,JPO&Japio
JP12014279A 1979-09-20 1979-09-20 Cyclohexanecarboxylic acid derivative and its preparation Granted JPS5645454A (en)

Priority Applications (22)

Application Number Priority Date Filing Date Title
JP12014279A JPS5645454A (en) 1979-09-20 1979-09-20 Cyclohexanecarboxylic acid derivative and its preparation
SE8006365A SE460667B (en) 1979-09-20 1980-09-11 CYCLOHEXANCHARBOXYLIC ACID DERIVATIVES, PROCEDURES FOR PREPARING THEREOF, AND THESE DERIVATIVES FOR THERAPEUTIC APPLICATION
AU62320/80A AU541738B2 (en) 1979-09-20 1980-09-11 Cyclohexane carboxylic acid derivatives
US06/186,849 US4348410A (en) 1979-09-20 1980-09-15 Cyclohexane carboxylic acid derivatives
DE19803035086 DE3035086A1 (en) 1979-09-20 1980-09-17 CYCLOHEXANCARBONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEANS CONTAINING THEM
BE0/202125A BE885263A (en) 1979-09-20 1980-09-17 DERIVATIVES OF CYCLOHEXANE-CARBOXYLIC ACIDS
GB8030183A GB2058773B (en) 1979-09-20 1980-09-18 Cyclohexane carboxylic acid derivatives
NL8005238A NL8005238A (en) 1979-09-20 1980-09-19 CYCLOHEXANE CARBONIC ACID DERIVATIVES.
AR282590A AR227525A1 (en) 1979-09-20 1980-09-19 PROCEDURE FOR OBTAINING CYCLOHEXANCARBOXYLIC ACID DERIVATIVES
DK396880A DK163580C (en) 1979-09-20 1980-09-19 METHOD OF ANALOGY FOR THE PREPARATION OF CYCLOHEXANCARBOXYLIC ACID DERIVATIVES
FR8020263A FR2472561B1 (en) 1979-09-20 1980-09-19 DERIVATIVES OF 4-GUANIDINOMETHYLCYCLOHEXANE CARBOXYLIC ACID, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
ES495175A ES8200643A1 (en) 1979-09-20 1980-09-19 Cyclohexane carboxylic acid derivatives
AT0470680A AT375918B (en) 1979-09-20 1980-09-19 METHOD FOR PRODUCING NEW ESTERS OF 4-GUANIDINOMETHYL-CYCLOHEXANCARBONIC ACID
IT68457/80A IT1129264B (en) 1979-09-20 1980-09-19 CYCLOHEXANCARBOXYLIC ACID DERIVATIVES PARTICULARLY USEFUL AS ANTI-ULTER AND PROCEDURE FOR THEIR PREPARATION
HU230880A HU184828B (en) 1979-09-20 1980-09-19 Process for preparing cyclohexane-carboxylic acid derivatives
PH24606A PH17322A (en) 1979-09-20 1980-09-19 Cyclohexane carboxylic acid derivative
CH706480A CH646687A5 (en) 1979-09-20 1980-09-19 DERIVATIVES OF CARBOXYLIC CYCLOHEXANE ACID.
CA000360655A CA1142943A (en) 1979-09-20 1980-09-19 4-guanidinomethylcyclohexane carboxylic acid compounds
IN1071/CAL/80A IN151297B (en) 1979-09-20 1980-09-20
MX867180A MX155236A (en) 1979-09-20 1980-09-22 PROCEDURE FOR PREPARING A COMPOUND DERIVED FROM CYCLOHEXAN-CARBOXYLIC ACID
BR8006052A BR8006052A (en) 1979-09-20 1980-09-23 PROCESS FOR THE PREPARATION OF CYCLE-HEXANIC CARBOXYLIC ACID DERIVATIVES
IN1514/CAL/82A IN155437B (en) 1979-09-20 1982-12-31

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12014279A JPS5645454A (en) 1979-09-20 1979-09-20 Cyclohexanecarboxylic acid derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS5645454A true JPS5645454A (en) 1981-04-25
JPS6324988B2 JPS6324988B2 (en) 1988-05-23

Family

ID=14778997

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12014279A Granted JPS5645454A (en) 1979-09-20 1979-09-20 Cyclohexanecarboxylic acid derivative and its preparation

Country Status (2)

Country Link
JP (1) JPS5645454A (en)
BE (1) BE885263A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996006825A1 (en) * 1994-08-30 1996-03-07 Teikoku Chemical Industries Co., Ltd. Guanidinomethyl cyclohexane carboxylic ester derivative
US6444703B1 (en) 1995-12-22 2002-09-03 Teikoku Chemical Industries Co., Ltd. Cyclohexane carbocyclic ester derivative and cyclodextrin complex and composition for treatment of helicobacter pylori infections

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4465851A (en) * 1981-01-22 1984-08-14 Nippon Chemiphar Co., Ltd. Guanidinocyclohexanecarboxylic acid derivatives
DE69533206D1 (en) * 1994-04-08 2004-07-29 Vlt Corp Power conversion with high efficiency

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JOURNAL.OF.MEDICINAL.CHEMISTRY.V15.N3. *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996006825A1 (en) * 1994-08-30 1996-03-07 Teikoku Chemical Industries Co., Ltd. Guanidinomethyl cyclohexane carboxylic ester derivative
US6284791B1 (en) 1994-08-30 2001-09-04 Teikoku Chemical Industries Co., Ltd. Guanidinomethyl cyclohexane carboxylic acid ester derivatives
US6831190B1 (en) 1994-08-30 2004-12-14 Teikoku Chemical Industries Co., Ltd. Guanidinomethyl cyclohexane carboxylic acid ester derivatives
US6444703B1 (en) 1995-12-22 2002-09-03 Teikoku Chemical Industries Co., Ltd. Cyclohexane carbocyclic ester derivative and cyclodextrin complex and composition for treatment of helicobacter pylori infections

Also Published As

Publication number Publication date
BE885263A (en) 1981-01-16
JPS6324988B2 (en) 1988-05-23

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