JPS5645467A - Pantolactone derivative and its preparation - Google Patents
Pantolactone derivative and its preparationInfo
- Publication number
- JPS5645467A JPS5645467A JP12014479A JP12014479A JPS5645467A JP S5645467 A JPS5645467 A JP S5645467A JP 12014479 A JP12014479 A JP 12014479A JP 12014479 A JP12014479 A JP 12014479A JP S5645467 A JPS5645467 A JP S5645467A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- pantolactone
- formula
- derivative
- reacted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:A pantolactone derivative expressed by the formula and an acid addition salt thereof.
EXAMPLE: 2'-D-Pantolacto diester hydrochloride of trans-4-aminomethylcyclohexanecarboxylic acid.
USE: An antiplasmin agent.
PROCESS: Tranexamic acid or a reactive derivative thereof is reacted with pantolactone in an organic solvent at room temperature to the boiling point of a solvent to give the compound of the formula. In case tranexamic acid is directly reacted with the pantolactone, the reaction is preferably carried out in the presence of a condensing agent used in the ester synthesis. The resultant compound can be converted into a salt of an inorganic or organic acid, e.g. hydrochloric, sulfuric acetic or maleic acid.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12014479A JPS5645467A (en) | 1979-09-20 | 1979-09-20 | Pantolactone derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12014479A JPS5645467A (en) | 1979-09-20 | 1979-09-20 | Pantolactone derivative and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5645467A true JPS5645467A (en) | 1981-04-25 |
JPS6323994B2 JPS6323994B2 (en) | 1988-05-18 |
Family
ID=14779047
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12014479A Granted JPS5645467A (en) | 1979-09-20 | 1979-09-20 | Pantolactone derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5645467A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4766148A (en) * | 1983-02-19 | 1988-08-23 | Kaken Pharmaceutical Co., Ltd. | Biphenylylpropionic acid derivative and pharmaceutical composition containing the same |
US5196567A (en) * | 1983-02-19 | 1993-03-23 | Kaken Pharmaceutical Co., Ltd. | Biphenylylpropionic acid derivative, process for preparing the same and pharmaceutical composition containing the same |
-
1979
- 1979-09-20 JP JP12014479A patent/JPS5645467A/en active Granted
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4766148A (en) * | 1983-02-19 | 1988-08-23 | Kaken Pharmaceutical Co., Ltd. | Biphenylylpropionic acid derivative and pharmaceutical composition containing the same |
US5196567A (en) * | 1983-02-19 | 1993-03-23 | Kaken Pharmaceutical Co., Ltd. | Biphenylylpropionic acid derivative, process for preparing the same and pharmaceutical composition containing the same |
Also Published As
Publication number | Publication date |
---|---|
JPS6323994B2 (en) | 1988-05-18 |
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