JPS5645467A - Pantolactone derivative and its preparation - Google Patents

Pantolactone derivative and its preparation

Info

Publication number
JPS5645467A
JPS5645467A JP12014479A JP12014479A JPS5645467A JP S5645467 A JPS5645467 A JP S5645467A JP 12014479 A JP12014479 A JP 12014479A JP 12014479 A JP12014479 A JP 12014479A JP S5645467 A JPS5645467 A JP S5645467A
Authority
JP
Japan
Prior art keywords
acid
pantolactone
formula
derivative
reacted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12014479A
Other languages
Japanese (ja)
Other versions
JPS6323994B2 (en
Inventor
Mutsumi Muramatsu
Toshio Sato
Yukio Yanagimoto
Tadami Shinnai
Toshio Nakajima
Isao Nakajima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Chemiphar Co Ltd
Aska Pharmaceutical Co Ltd
Teikoku Chemical Industry Co Ltd
Original Assignee
Nippon Chemiphar Co Ltd
Teikoku Chemical Industry Co Ltd
Teikoku Hormone Manufacturing Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Chemiphar Co Ltd, Teikoku Chemical Industry Co Ltd, Teikoku Hormone Manufacturing Co Ltd filed Critical Nippon Chemiphar Co Ltd
Priority to JP12014479A priority Critical patent/JPS5645467A/en
Publication of JPS5645467A publication Critical patent/JPS5645467A/en
Publication of JPS6323994B2 publication Critical patent/JPS6323994B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:A pantolactone derivative expressed by the formula and an acid addition salt thereof.
EXAMPLE: 2'-D-Pantolacto diester hydrochloride of trans-4-aminomethylcyclohexanecarboxylic acid.
USE: An antiplasmin agent.
PROCESS: Tranexamic acid or a reactive derivative thereof is reacted with pantolactone in an organic solvent at room temperature to the boiling point of a solvent to give the compound of the formula. In case tranexamic acid is directly reacted with the pantolactone, the reaction is preferably carried out in the presence of a condensing agent used in the ester synthesis. The resultant compound can be converted into a salt of an inorganic or organic acid, e.g. hydrochloric, sulfuric acetic or maleic acid.
COPYRIGHT: (C)1981,JPO&Japio
JP12014479A 1979-09-20 1979-09-20 Pantolactone derivative and its preparation Granted JPS5645467A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12014479A JPS5645467A (en) 1979-09-20 1979-09-20 Pantolactone derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12014479A JPS5645467A (en) 1979-09-20 1979-09-20 Pantolactone derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS5645467A true JPS5645467A (en) 1981-04-25
JPS6323994B2 JPS6323994B2 (en) 1988-05-18

Family

ID=14779047

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12014479A Granted JPS5645467A (en) 1979-09-20 1979-09-20 Pantolactone derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5645467A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4766148A (en) * 1983-02-19 1988-08-23 Kaken Pharmaceutical Co., Ltd. Biphenylylpropionic acid derivative and pharmaceutical composition containing the same
US5196567A (en) * 1983-02-19 1993-03-23 Kaken Pharmaceutical Co., Ltd. Biphenylylpropionic acid derivative, process for preparing the same and pharmaceutical composition containing the same

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4766148A (en) * 1983-02-19 1988-08-23 Kaken Pharmaceutical Co., Ltd. Biphenylylpropionic acid derivative and pharmaceutical composition containing the same
US5196567A (en) * 1983-02-19 1993-03-23 Kaken Pharmaceutical Co., Ltd. Biphenylylpropionic acid derivative, process for preparing the same and pharmaceutical composition containing the same

Also Published As

Publication number Publication date
JPS6323994B2 (en) 1988-05-18

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