JPS54144320A - Preparation of ureidomethylene malonic ester - Google Patents
Preparation of ureidomethylene malonic esterInfo
- Publication number
- JPS54144320A JPS54144320A JP5318978A JP5318978A JPS54144320A JP S54144320 A JPS54144320 A JP S54144320A JP 5318978 A JP5318978 A JP 5318978A JP 5318978 A JP5318978 A JP 5318978A JP S54144320 A JPS54144320 A JP S54144320A
- Authority
- JP
- Japan
- Prior art keywords
- malonic ester
- ureidomethylene
- preparation
- acid catalyst
- urea
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain the title compound useful as an intermediate for the synthesis of medicines, e.g. 5-fluorouracil, in high yield, by reacting an alkoxymethylene malonic ester with urea in the presence of an acid catalyst.
CONSTITUTION: An alkoxymethylene malonic ester of formula I: (R and R' are alkyl groups) is reacted with urea in the presence of an acid catalyst to give a ureidomethylene malonic ester of formula II in a high yield ≥85%. An inorganic, organic, or Lewis acid may be used as the acid catalyst.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5318978A JPS54144320A (en) | 1978-05-02 | 1978-05-02 | Preparation of ureidomethylene malonic ester |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5318978A JPS54144320A (en) | 1978-05-02 | 1978-05-02 | Preparation of ureidomethylene malonic ester |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS54144320A true JPS54144320A (en) | 1979-11-10 |
JPS6145615B2 JPS6145615B2 (en) | 1986-10-08 |
Family
ID=12935920
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP5318978A Granted JPS54144320A (en) | 1978-05-02 | 1978-05-02 | Preparation of ureidomethylene malonic ester |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54144320A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107602420A (en) * | 2017-09-02 | 2018-01-19 | 青岛科技大学 | A kind of technique of batch reactive distillation synthesis urea methylene dimethyl malenate |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS52131529A (en) * | 1976-04-26 | 1977-11-04 | Takeda Chem Ind Ltd | Production of ureidomethylenemalonic ester |
-
1978
- 1978-05-02 JP JP5318978A patent/JPS54144320A/en active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS52131529A (en) * | 1976-04-26 | 1977-11-04 | Takeda Chem Ind Ltd | Production of ureidomethylenemalonic ester |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107602420A (en) * | 2017-09-02 | 2018-01-19 | 青岛科技大学 | A kind of technique of batch reactive distillation synthesis urea methylene dimethyl malenate |
CN107602420B (en) * | 2017-09-02 | 2020-06-12 | 青岛科技大学 | Process for synthesizing dimethyl urethanene malonate by batch reaction rectification |
Also Published As
Publication number | Publication date |
---|---|
JPS6145615B2 (en) | 1986-10-08 |
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