JPS54160394A - Preparation of 1-(5-oxo-hexyl)theobromine - Google Patents
Preparation of 1-(5-oxo-hexyl)theobromineInfo
- Publication number
- JPS54160394A JPS54160394A JP6746978A JP6746978A JPS54160394A JP S54160394 A JPS54160394 A JP S54160394A JP 6746978 A JP6746978 A JP 6746978A JP 6746978 A JP6746978 A JP 6746978A JP S54160394 A JPS54160394 A JP S54160394A
- Authority
- JP
- Japan
- Prior art keywords
- theobromine
- formula
- compound
- oxo
- hexyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To obtain the title compound useful as vasodilators and hematocytolysis promotors in high yield and purity in a simple process, by reacting theobromine with easily available 6-hydroxy-2-hexanone in the presence of a specific condensing agent.
CONSTITUTION: Theobromine (T) of formula I condensed with a compound (C) of formula III through dehydration in the presence of a compound (D) of formula II at a molar ratio of (T) : (C) : (D) of 1:1.2W5:1.2W5 at 50W200°C to give 1- (5-oxohexyl)-theobromine of formula IV. The compound of formula III is readily obtained by hydrolyzing 2-methyl-3-ethoxycarbonyl-5,6-dihydropyran with a dilute acid, and by decarboxylating the hydrolysis product.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6746978A JPS54160394A (en) | 1978-06-05 | 1978-06-05 | Preparation of 1-(5-oxo-hexyl)theobromine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6746978A JPS54160394A (en) | 1978-06-05 | 1978-06-05 | Preparation of 1-(5-oxo-hexyl)theobromine |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS54160394A true JPS54160394A (en) | 1979-12-19 |
Family
ID=13345839
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6746978A Pending JPS54160394A (en) | 1978-06-05 | 1978-06-05 | Preparation of 1-(5-oxo-hexyl)theobromine |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54160394A (en) |
-
1978
- 1978-06-05 JP JP6746978A patent/JPS54160394A/en active Pending
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