JPS5770865A - Preparation of 5-aroylpyrrole-2-acetic acid derivative - Google Patents
Preparation of 5-aroylpyrrole-2-acetic acid derivativeInfo
- Publication number
- JPS5770865A JPS5770865A JP14728780A JP14728780A JPS5770865A JP S5770865 A JPS5770865 A JP S5770865A JP 14728780 A JP14728780 A JP 14728780A JP 14728780 A JP14728780 A JP 14728780A JP S5770865 A JPS5770865 A JP S5770865A
- Authority
- JP
- Japan
- Prior art keywords
- compound expressed
- methyl
- formula
- ethyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To obtain the titled compound useful as an anti-inflammatory agent in high yield, by reacting a novel compound as a starting substance with ammonia to an amine in the presence of water and an acid, and hydrolyzing the reaction product.
CONSTITUTION: A novel compound expressed by formulaI(Ar is p-tolyl or p- chlorophenyl; R1 is methyl or ethyl or together the other R1 may form ethylene or trimethylene; R2 is H or methyl; R3 is 1W6C alkyl; R4 is methyl or ethyl), e.g. methyl 5-(α,α-dimethoxy-p-methylbenzyl)-2,5-dimethoxytetrahydeofuran-2-acetate, is reacted with a compound expressed by the formula R5-NH2 (R5 is H, methyl or ethyl) in the presence of water and an acid to give a compound expressed by formula II, which is then hydrolyzed to afford the amied compound expressed by formula III. The compound expressed by formulaIis obtained by reacting a compound expressed by formula IV as a raw material with a compound expressed by the formula ArCOCl, converting the reaction product into a ketal, alkoxylating the ketal, and reducing the resultant alkoxylation product.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14728780A JPS5770865A (en) | 1980-10-20 | 1980-10-20 | Preparation of 5-aroylpyrrole-2-acetic acid derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14728780A JPS5770865A (en) | 1980-10-20 | 1980-10-20 | Preparation of 5-aroylpyrrole-2-acetic acid derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5770865A true JPS5770865A (en) | 1982-05-01 |
Family
ID=15426782
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14728780A Pending JPS5770865A (en) | 1980-10-20 | 1980-10-20 | Preparation of 5-aroylpyrrole-2-acetic acid derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5770865A (en) |
-
1980
- 1980-10-20 JP JP14728780A patent/JPS5770865A/en active Pending
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