JPS5770865A - Preparation of 5-aroylpyrrole-2-acetic acid derivative - Google Patents

Preparation of 5-aroylpyrrole-2-acetic acid derivative

Info

Publication number
JPS5770865A
JPS5770865A JP14728780A JP14728780A JPS5770865A JP S5770865 A JPS5770865 A JP S5770865A JP 14728780 A JP14728780 A JP 14728780A JP 14728780 A JP14728780 A JP 14728780A JP S5770865 A JPS5770865 A JP S5770865A
Authority
JP
Japan
Prior art keywords
compound expressed
methyl
formula
ethyl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP14728780A
Other languages
Japanese (ja)
Inventor
Hiroaki Kinugasa
Kaoru Yoshida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MAKUNEIRU LAB Inc
Dainippon Pharmaceutical Co Ltd
Janssen Pharmaceuticals Inc
Original Assignee
MAKUNEIRU LAB Inc
Dainippon Pharmaceutical Co Ltd
McNeilab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MAKUNEIRU LAB Inc, Dainippon Pharmaceutical Co Ltd, McNeilab Inc filed Critical MAKUNEIRU LAB Inc
Priority to JP14728780A priority Critical patent/JPS5770865A/en
Publication of JPS5770865A publication Critical patent/JPS5770865A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To obtain the titled compound useful as an anti-inflammatory agent in high yield, by reacting a novel compound as a starting substance with ammonia to an amine in the presence of water and an acid, and hydrolyzing the reaction product.
CONSTITUTION: A novel compound expressed by formulaI(Ar is p-tolyl or p- chlorophenyl; R1 is methyl or ethyl or together the other R1 may form ethylene or trimethylene; R2 is H or methyl; R3 is 1W6C alkyl; R4 is methyl or ethyl), e.g. methyl 5-(α,α-dimethoxy-p-methylbenzyl)-2,5-dimethoxytetrahydeofuran-2-acetate, is reacted with a compound expressed by the formula R5-NH2 (R5 is H, methyl or ethyl) in the presence of water and an acid to give a compound expressed by formula II, which is then hydrolyzed to afford the amied compound expressed by formula III. The compound expressed by formulaIis obtained by reacting a compound expressed by formula IV as a raw material with a compound expressed by the formula ArCOCl, converting the reaction product into a ketal, alkoxylating the ketal, and reducing the resultant alkoxylation product.
COPYRIGHT: (C)1982,JPO&Japio
JP14728780A 1980-10-20 1980-10-20 Preparation of 5-aroylpyrrole-2-acetic acid derivative Pending JPS5770865A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14728780A JPS5770865A (en) 1980-10-20 1980-10-20 Preparation of 5-aroylpyrrole-2-acetic acid derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14728780A JPS5770865A (en) 1980-10-20 1980-10-20 Preparation of 5-aroylpyrrole-2-acetic acid derivative

Publications (1)

Publication Number Publication Date
JPS5770865A true JPS5770865A (en) 1982-05-01

Family

ID=15426782

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14728780A Pending JPS5770865A (en) 1980-10-20 1980-10-20 Preparation of 5-aroylpyrrole-2-acetic acid derivative

Country Status (1)

Country Link
JP (1) JPS5770865A (en)

Similar Documents

Publication Publication Date Title
JPS5767534A (en) Preparation of alpha,beta-unsaturated carboxylic ester and alpha,beta-unsaturated carboxylic acid
JPS5770865A (en) Preparation of 5-aroylpyrrole-2-acetic acid derivative
JPS5721341A (en) Preparation of substituted acetic ester
JPS5695142A (en) Preparation of aliphatic aldehyde
JPS559025A (en) Preparation of polyfluoroalcohol
JPS5711981A (en) Theobromine derivative and its preparation
JPS57146790A (en) Novel synthesis of organopolysilane
SU1477729A1 (en) Method of producing 4-hydroxy-8-carboxyquinolone-2
JPS5527161A (en) Production of alcohol or its ether derivative
JPS54144320A (en) Preparation of ureidomethylene malonic ester
JPS5441869A (en) 1-methylsulfinyl-1-methylthio-2-(n-alkylpyrrolyl-2)- ethylene
JPS55143925A (en) Preparation of cyclopentenolone
JPS57130971A (en) Preparation of 4-(3-amino-2-hydroxy-propoxy)indole
JPS55127380A (en) Preparation of glycidyl ester
JPS55143960A (en) Novel acetal compound and its preparation
JPS54125678A (en) Preparation of 4-hydroxy-6-methylnicotinic acid
JPS56158738A (en) Preparation of 2-substituted-3-oxo-cyclopentylacetic ester
JPS55102537A (en) Preparation of 4-hydroxymandelic acid
JPS55104271A (en) Preparation of uracil-5-carboxylic ester
JPS5562050A (en) Preparation of substituted phenylacetohydroxamic acid
JPS5622753A (en) Preparation of alpha-halogeno-beta-alanine or its salt of mineral acid
JPS55111440A (en) Preparation of straight-chain higher carboxylic acid
JPS55108856A (en) Preparation of 1-alkyl-3-methyl-5-pyrazolone
JPS55133371A (en) Preparation of gamma-alkyl-gamma-lactone
JPS5746951A (en) Production of 2-amino-4-cyanobutyric derivative