JPS55102537A - Preparation of 4-hydroxymandelic acid - Google Patents
Preparation of 4-hydroxymandelic acidInfo
- Publication number
- JPS55102537A JPS55102537A JP416580A JP416580A JPS55102537A JP S55102537 A JPS55102537 A JP S55102537A JP 416580 A JP416580 A JP 416580A JP 416580 A JP416580 A JP 416580A JP S55102537 A JPS55102537 A JP S55102537A
- Authority
- JP
- Japan
- Prior art keywords
- solvent
- phenol
- glyoxylic acid
- preparation
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To obtain the title substance useful as a raw material for the intermediate of medicines, pesticides, and perfumes, in high purity and yield in a short time, by extracting the reaction product, prepared from phenol and glyoxylic acid in a relatively high temperature range, with a solvent.
CONSTITUTION: Phenol(P) is reacted with glyoxylic acid(G) in an aqueous medium in the presence of an alkali(A) at 40W100°C, preferably 60W90°C, to give a reaction mixture, which is extracted with a solvent to afford the title compound. A lower alkyl ester of acetic acid, e.g. methyl or ethyl acetate, or ether, e.g. diethyl ether, an aliphatic ketone, e.g. methyl isobutyl ketone, may be used as the solvent. The molar ratio of G:P:A is 1:0.8W10:1W5, preferably 1:1.2W3.5:1.2W4.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP416580A JPS55102537A (en) | 1980-01-16 | 1980-01-16 | Preparation of 4-hydroxymandelic acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP416580A JPS55102537A (en) | 1980-01-16 | 1980-01-16 | Preparation of 4-hydroxymandelic acid |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP53161813 Division |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS55102537A true JPS55102537A (en) | 1980-08-05 |
Family
ID=11577123
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP416580A Pending JPS55102537A (en) | 1980-01-16 | 1980-01-16 | Preparation of 4-hydroxymandelic acid |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55102537A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4978784A (en) * | 1988-11-08 | 1990-12-18 | Societe Francaise Hoechst | Process for industrial manufacture of sodium parahydroxymandelate |
WO1994014746A1 (en) * | 1992-12-23 | 1994-07-07 | Technische Universiteit Delft | Process for separating the ortho- and para- isomers of hydroxymandelic acid or a salt thereof, the isomers thus obtained, the use of the ortho-isomer for the preparation of eddha |
-
1980
- 1980-01-16 JP JP416580A patent/JPS55102537A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4978784A (en) * | 1988-11-08 | 1990-12-18 | Societe Francaise Hoechst | Process for industrial manufacture of sodium parahydroxymandelate |
WO1994014746A1 (en) * | 1992-12-23 | 1994-07-07 | Technische Universiteit Delft | Process for separating the ortho- and para- isomers of hydroxymandelic acid or a salt thereof, the isomers thus obtained, the use of the ortho-isomer for the preparation of eddha |
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