JPS55102537A - Preparation of 4-hydroxymandelic acid - Google Patents

Preparation of 4-hydroxymandelic acid

Info

Publication number
JPS55102537A
JPS55102537A JP416580A JP416580A JPS55102537A JP S55102537 A JPS55102537 A JP S55102537A JP 416580 A JP416580 A JP 416580A JP 416580 A JP416580 A JP 416580A JP S55102537 A JPS55102537 A JP S55102537A
Authority
JP
Japan
Prior art keywords
solvent
phenol
glyoxylic acid
preparation
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP416580A
Other languages
Japanese (ja)
Inventor
Kazuhisa Nakajima
Kazuaki Gogi
Toshio Yamamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Synthetic Chemical Industry Co Ltd
Original Assignee
Nippon Synthetic Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Synthetic Chemical Industry Co Ltd filed Critical Nippon Synthetic Chemical Industry Co Ltd
Priority to JP416580A priority Critical patent/JPS55102537A/en
Publication of JPS55102537A publication Critical patent/JPS55102537A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To obtain the title substance useful as a raw material for the intermediate of medicines, pesticides, and perfumes, in high purity and yield in a short time, by extracting the reaction product, prepared from phenol and glyoxylic acid in a relatively high temperature range, with a solvent.
CONSTITUTION: Phenol(P) is reacted with glyoxylic acid(G) in an aqueous medium in the presence of an alkali(A) at 40W100°C, preferably 60W90°C, to give a reaction mixture, which is extracted with a solvent to afford the title compound. A lower alkyl ester of acetic acid, e.g. methyl or ethyl acetate, or ether, e.g. diethyl ether, an aliphatic ketone, e.g. methyl isobutyl ketone, may be used as the solvent. The molar ratio of G:P:A is 1:0.8W10:1W5, preferably 1:1.2W3.5:1.2W4.
COPYRIGHT: (C)1980,JPO&Japio
JP416580A 1980-01-16 1980-01-16 Preparation of 4-hydroxymandelic acid Pending JPS55102537A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP416580A JPS55102537A (en) 1980-01-16 1980-01-16 Preparation of 4-hydroxymandelic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP416580A JPS55102537A (en) 1980-01-16 1980-01-16 Preparation of 4-hydroxymandelic acid

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP53161813 Division

Publications (1)

Publication Number Publication Date
JPS55102537A true JPS55102537A (en) 1980-08-05

Family

ID=11577123

Family Applications (1)

Application Number Title Priority Date Filing Date
JP416580A Pending JPS55102537A (en) 1980-01-16 1980-01-16 Preparation of 4-hydroxymandelic acid

Country Status (1)

Country Link
JP (1) JPS55102537A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4978784A (en) * 1988-11-08 1990-12-18 Societe Francaise Hoechst Process for industrial manufacture of sodium parahydroxymandelate
WO1994014746A1 (en) * 1992-12-23 1994-07-07 Technische Universiteit Delft Process for separating the ortho- and para- isomers of hydroxymandelic acid or a salt thereof, the isomers thus obtained, the use of the ortho-isomer for the preparation of eddha

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4978784A (en) * 1988-11-08 1990-12-18 Societe Francaise Hoechst Process for industrial manufacture of sodium parahydroxymandelate
WO1994014746A1 (en) * 1992-12-23 1994-07-07 Technische Universiteit Delft Process for separating the ortho- and para- isomers of hydroxymandelic acid or a salt thereof, the isomers thus obtained, the use of the ortho-isomer for the preparation of eddha

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