JPS5585540A - Separation of cis- and trans-1-methyl-4-isohexyl- cyclohexanecarboxylic acid - Google Patents

Separation of cis- and trans-1-methyl-4-isohexyl- cyclohexanecarboxylic acid

Info

Publication number
JPS5585540A
JPS5585540A JP16171678A JP16171678A JPS5585540A JP S5585540 A JPS5585540 A JP S5585540A JP 16171678 A JP16171678 A JP 16171678A JP 16171678 A JP16171678 A JP 16171678A JP S5585540 A JPS5585540 A JP S5585540A
Authority
JP
Japan
Prior art keywords
trans
species
cis
methyl
isohexylcyclohexanecarboxylic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP16171678A
Other languages
Japanese (ja)
Inventor
Kanji Noda
Akira Nakagawa
Munehiko Hirano
Kenji Yamagata
Yoichi Nakajima
Terumi Yatani
Hiroyuki Ide
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hisamitsu Pharmaceutical Co Inc
Original Assignee
Hisamitsu Pharmaceutical Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hisamitsu Pharmaceutical Co Inc filed Critical Hisamitsu Pharmaceutical Co Inc
Priority to JP16171678A priority Critical patent/JPS5585540A/en
Publication of JPS5585540A publication Critical patent/JPS5585540A/en
Pending legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To separate a cis- and trans-1-methyl-4-isohexylcyclohexanecarboxylic acids mixture into its constituents, in simple reaction processes, by selectively esterifying the trans species of the acid.
CONSTITUTION: A mixture of cis- and trans-1-methyl-4-isohexylcyclohexanecarboxylic acids is esterified in an alcohol such as methanol at 30W50°C for 3W8hrs in the presence of concentrated sulfuric acid, whereby trans-1-methyl-4-isohexylcyclohexanecarboxylic acid ester and free cis species are obtained. They are easily separated by adding cold KOH aqueous solution to obtain cis species and the dsterified trans species. Subsequently, the esterified trans species is converted to the free trans species using a mineral acid or a caustic alkali.
EFFECT: The desired compounds are obtained in high yield and purity, at low costs.
USE: Medicines.
COPYRIGHT: (C)1980,JPO&Japio
JP16171678A 1978-12-22 1978-12-22 Separation of cis- and trans-1-methyl-4-isohexyl- cyclohexanecarboxylic acid Pending JPS5585540A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP16171678A JPS5585540A (en) 1978-12-22 1978-12-22 Separation of cis- and trans-1-methyl-4-isohexyl- cyclohexanecarboxylic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP16171678A JPS5585540A (en) 1978-12-22 1978-12-22 Separation of cis- and trans-1-methyl-4-isohexyl- cyclohexanecarboxylic acid

Publications (1)

Publication Number Publication Date
JPS5585540A true JPS5585540A (en) 1980-06-27

Family

ID=15740513

Family Applications (1)

Application Number Title Priority Date Filing Date
JP16171678A Pending JPS5585540A (en) 1978-12-22 1978-12-22 Separation of cis- and trans-1-methyl-4-isohexyl- cyclohexanecarboxylic acid

Country Status (1)

Country Link
JP (1) JPS5585540A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102249900A (en) * 2011-05-16 2011-11-23 浙江师范大学 Method for separation and purification of 2-adamantanecarboxylic acid and 1-adamantanecarboxylic acid

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102249900A (en) * 2011-05-16 2011-11-23 浙江师范大学 Method for separation and purification of 2-adamantanecarboxylic acid and 1-adamantanecarboxylic acid

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