JPS5585538A - Separation of cis- and trans-1-methyl-4-isohexyl- cyclohexanecarboxylic acid - Google Patents
Separation of cis- and trans-1-methyl-4-isohexyl- cyclohexanecarboxylic acidInfo
- Publication number
- JPS5585538A JPS5585538A JP16171478A JP16171478A JPS5585538A JP S5585538 A JPS5585538 A JP S5585538A JP 16171478 A JP16171478 A JP 16171478A JP 16171478 A JP16171478 A JP 16171478A JP S5585538 A JPS5585538 A JP S5585538A
- Authority
- JP
- Japan
- Prior art keywords
- trans
- cis
- methyl
- species
- isohexylcyclohexanecarboxylic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To obtain the title compounds useful as medicines, in simple reaction processes, in high purity and yield, by separating trans species from a cis- and trans- 1-methyl-4-isohexylcyclohexanecarboxylic acid mixture as a clathrate compound.
CONSTITUTION: A mixture of cis- and trans-1-methyl-4-isohexylcyclohexanecarboxylic acids is added to a saturated hot methanol solution of urea or thiourea, cooled after heating at 40W65°C for 5W15min, and separated into its constituents by filtration. The molar ratio of urea or thiourea to the trans species of the carboxylic acid is 10W14 to 1. A clathrate compound of trans-1-methyl-4-isohexylcyclohexanecarboxylic acid (trans species) thus obtained as a residue is isolated by adding dilute aqueous solution of sodium hydroxide to the clathrate compound, and subsequently making acidic with hydrochloric acid. The cis species can be separated from methanol layer of the filtrate.
EFFECT: Low cost.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16171478A JPS5585538A (en) | 1978-12-22 | 1978-12-22 | Separation of cis- and trans-1-methyl-4-isohexyl- cyclohexanecarboxylic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16171478A JPS5585538A (en) | 1978-12-22 | 1978-12-22 | Separation of cis- and trans-1-methyl-4-isohexyl- cyclohexanecarboxylic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5585538A true JPS5585538A (en) | 1980-06-27 |
Family
ID=15740475
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP16171478A Pending JPS5585538A (en) | 1978-12-22 | 1978-12-22 | Separation of cis- and trans-1-methyl-4-isohexyl- cyclohexanecarboxylic acid |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5585538A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5775950A (en) * | 1980-10-28 | 1982-05-12 | Seiko Epson Corp | Purification of liquid crystal compound |
| EP0415697A2 (en) * | 1989-08-29 | 1991-03-06 | Unichema Chemie B.V. | Process for treating fatty acids |
| CN112142546A (en) * | 2020-11-03 | 2020-12-29 | 湖南经世新材料有限责任公司 | Separation and enrichment method of trans-cyclohexyl-containing organic molecules |
-
1978
- 1978-12-22 JP JP16171478A patent/JPS5585538A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5775950A (en) * | 1980-10-28 | 1982-05-12 | Seiko Epson Corp | Purification of liquid crystal compound |
| EP0415697A2 (en) * | 1989-08-29 | 1991-03-06 | Unichema Chemie B.V. | Process for treating fatty acids |
| CN112142546A (en) * | 2020-11-03 | 2020-12-29 | 湖南经世新材料有限责任公司 | Separation and enrichment method of trans-cyclohexyl-containing organic molecules |
| CN112142546B (en) * | 2020-11-03 | 2023-05-30 | 湖南经世新材料有限责任公司 | Separation and enrichment method of organic molecules containing trans-cyclohexyl |
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