JPS54125678A - Preparation of 4-hydroxy-6-methylnicotinic acid - Google Patents
Preparation of 4-hydroxy-6-methylnicotinic acidInfo
- Publication number
- JPS54125678A JPS54125678A JP3055378A JP3055378A JPS54125678A JP S54125678 A JPS54125678 A JP S54125678A JP 3055378 A JP3055378 A JP 3055378A JP 3055378 A JP3055378 A JP 3055378A JP S54125678 A JPS54125678 A JP S54125678A
- Authority
- JP
- Japan
- Prior art keywords
- hydroxy
- pyrone
- methyl
- compound
- dihydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: To prepare the title compound useful as a raw material of penicillin, etc., in high yield, without using expensive and hazardous compounds, from a specific compound obtained by the reaction of 4-hydroxy-6-methyl-3,4-dihydro-pyrone with a substituted aniline.
CONSTITUTION: 4-Hydroxy-6-methyl-2-pyrone-3-carboaldehyde of formula II is prepared by the hydrolysis of 3-substituted-anilinomethylene-6-methyl-4-oxo-3, 4-dihydro-2-pyrone of formula I (R is nitro, lower alkoxy, halogen) in an alkaline solution such as an aqueous solution of K2CO3, Na2CO3, etc. Reaction of the compound II with an amine compound such as dimethylamine in the presence of ammonia affords 4-hydroxy-6-methylnicotinic acid of formula III. The compound I is prepared by the reaction of 4-hydroxy-6-methyl-3,4-dihydro-2-pyrone with a substituted aniline.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3055378A JPS6051468B2 (en) | 1978-03-17 | 1978-03-17 | Method for producing 4-hydroxy-6-methylnicotinic acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3055378A JPS6051468B2 (en) | 1978-03-17 | 1978-03-17 | Method for producing 4-hydroxy-6-methylnicotinic acid |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS54125678A true JPS54125678A (en) | 1979-09-29 |
JPS6051468B2 JPS6051468B2 (en) | 1985-11-14 |
Family
ID=12306976
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3055378A Expired JPS6051468B2 (en) | 1978-03-17 | 1978-03-17 | Method for producing 4-hydroxy-6-methylnicotinic acid |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6051468B2 (en) |
-
1978
- 1978-03-17 JP JP3055378A patent/JPS6051468B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
JPS6051468B2 (en) | 1985-11-14 |
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