JPS54125678A - Preparation of 4-hydroxy-6-methylnicotinic acid - Google Patents

Preparation of 4-hydroxy-6-methylnicotinic acid

Info

Publication number
JPS54125678A
JPS54125678A JP3055378A JP3055378A JPS54125678A JP S54125678 A JPS54125678 A JP S54125678A JP 3055378 A JP3055378 A JP 3055378A JP 3055378 A JP3055378 A JP 3055378A JP S54125678 A JPS54125678 A JP S54125678A
Authority
JP
Japan
Prior art keywords
hydroxy
pyrone
methyl
compound
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP3055378A
Other languages
Japanese (ja)
Other versions
JPS6051468B2 (en
Inventor
Yukiyasu Murakami
Ichiro Isaka
Akio Koda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Priority to JP3055378A priority Critical patent/JPS6051468B2/en
Publication of JPS54125678A publication Critical patent/JPS54125678A/en
Publication of JPS6051468B2 publication Critical patent/JPS6051468B2/en
Expired legal-status Critical Current

Links

Abstract

PURPOSE: To prepare the title compound useful as a raw material of penicillin, etc., in high yield, without using expensive and hazardous compounds, from a specific compound obtained by the reaction of 4-hydroxy-6-methyl-3,4-dihydro-pyrone with a substituted aniline.
CONSTITUTION: 4-Hydroxy-6-methyl-2-pyrone-3-carboaldehyde of formula II is prepared by the hydrolysis of 3-substituted-anilinomethylene-6-methyl-4-oxo-3, 4-dihydro-2-pyrone of formula I (R is nitro, lower alkoxy, halogen) in an alkaline solution such as an aqueous solution of K2CO3, Na2CO3, etc. Reaction of the compound II with an amine compound such as dimethylamine in the presence of ammonia affords 4-hydroxy-6-methylnicotinic acid of formula III. The compound I is prepared by the reaction of 4-hydroxy-6-methyl-3,4-dihydro-2-pyrone with a substituted aniline.
COPYRIGHT: (C)1979,JPO&Japio
JP3055378A 1978-03-17 1978-03-17 Method for producing 4-hydroxy-6-methylnicotinic acid Expired JPS6051468B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3055378A JPS6051468B2 (en) 1978-03-17 1978-03-17 Method for producing 4-hydroxy-6-methylnicotinic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3055378A JPS6051468B2 (en) 1978-03-17 1978-03-17 Method for producing 4-hydroxy-6-methylnicotinic acid

Publications (2)

Publication Number Publication Date
JPS54125678A true JPS54125678A (en) 1979-09-29
JPS6051468B2 JPS6051468B2 (en) 1985-11-14

Family

ID=12306976

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3055378A Expired JPS6051468B2 (en) 1978-03-17 1978-03-17 Method for producing 4-hydroxy-6-methylnicotinic acid

Country Status (1)

Country Link
JP (1) JPS6051468B2 (en)

Also Published As

Publication number Publication date
JPS6051468B2 (en) 1985-11-14

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