JPS574978A - Preparation of benzothiazole-2-sulfonamide compound - Google Patents

Preparation of benzothiazole-2-sulfonamide compound

Info

Publication number
JPS574978A
JPS574978A JP7988380A JP7988380A JPS574978A JP S574978 A JPS574978 A JP S574978A JP 7988380 A JP7988380 A JP 7988380A JP 7988380 A JP7988380 A JP 7988380A JP S574978 A JPS574978 A JP S574978A
Authority
JP
Japan
Prior art keywords
formula
aqueous solution
amine
amine salt
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP7988380A
Other languages
Japanese (ja)
Other versions
JPS5827273B2 (en
Inventor
Hideo Oda
Masashige Yamagata
Yasunori Hirahara
Yutaka Kawaoka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanshin Chemical Industry Co Ltd
Original Assignee
Sanshin Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanshin Chemical Industry Co Ltd filed Critical Sanshin Chemical Industry Co Ltd
Priority to JP7988380A priority Critical patent/JPS5827273B2/en
Publication of JPS574978A publication Critical patent/JPS574978A/en
Publication of JPS5827273B2 publication Critical patent/JPS5827273B2/en
Expired legal-status Critical Current

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  • Thiazole And Isothizaole Compounds (AREA)

Abstract

PURPOSE: To obtain the titled compound advantageously, by mixing an aqueous solution of an alkali metal salt of benzothiazole-2-sulfinic acid, etc. with an amine, adding an acid to the mixture until an amine salt is formed, and oxidizing the amine salt with an aqueous solution of an alkali metal hypochlorite, etc. through condensation etc.
CONSTITUTION: An aqueous solution of an easily treatable compound shown by the formula I (R is H, halogen, lower alkyl, lower alkoxy, acetaminde, or NO2, X is alkali metal or alkaline earth metal) as a raw material is mixed with an amine shown by the formula II [R1 and R2 are H, alkyl, cycloalkyl, oxyethylene, naphthyl, group shown by the formula III (R3 is H, lower alkyl, NO2, COOH)], and an acid is added to the prepared mixture until an amine salt of a sulfinic acid shown by the formula I is formed. Without being separated, the amine salt is directly oxidized with an aqueous solution of an inexpensive alkali or alkaline earth metal hypochlorite through condensation to give a compound shown by the formula IV useful as an intermediate for a rubber compounding ingredient, etc. in high productivity, economically, and in high yield.
COPYRIGHT: (C)1982,JPO&Japio
JP7988380A 1980-06-12 1980-06-12 Method for producing benzothiazole-2-sulfonamide compound Expired JPS5827273B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP7988380A JPS5827273B2 (en) 1980-06-12 1980-06-12 Method for producing benzothiazole-2-sulfonamide compound

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7988380A JPS5827273B2 (en) 1980-06-12 1980-06-12 Method for producing benzothiazole-2-sulfonamide compound

Publications (2)

Publication Number Publication Date
JPS574978A true JPS574978A (en) 1982-01-11
JPS5827273B2 JPS5827273B2 (en) 1983-06-08

Family

ID=13702643

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7988380A Expired JPS5827273B2 (en) 1980-06-12 1980-06-12 Method for producing benzothiazole-2-sulfonamide compound

Country Status (1)

Country Link
JP (1) JPS5827273B2 (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5967277A (en) * 1982-09-09 1984-04-16 バイエル・アクチエンゲゼルシヤフト Manufacture of sterically hindered 2-benzothiazole sulfenam-ide
US4456599A (en) * 1983-04-22 1984-06-26 Merck & Co., Inc. Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure
US4470991A (en) * 1983-04-22 1984-09-11 Merck & Co., Inc. Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure
US4472418A (en) * 1983-04-22 1984-09-18 Merck & Co., Inc. Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure
US4472417A (en) * 1983-04-22 1984-09-18 Merck & Co., Inc. Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure
JPS59176270A (en) * 1983-03-17 1984-10-05 メルク・エンド・カムパニ−・インコ−ポレ−テツド Benzothiazole-2-sulfonamide derivative for locally treating intraocular pressure rise
US4500538A (en) * 1983-03-14 1985-02-19 Merck & Co., Inc. Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure
KR100351743B1 (en) * 1999-11-12 2002-09-11 미원상사주식회사 Process for preparation of the n,n-dicyclohexyl-2-benzothiazole sulfenamide
KR20030084444A (en) * 2002-04-26 2003-11-01 주식회사 파나진 A Novel Monomer For Synthesis of PNA Oligomer And A Process For Producing The Same

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5967277A (en) * 1982-09-09 1984-04-16 バイエル・アクチエンゲゼルシヤフト Manufacture of sterically hindered 2-benzothiazole sulfenam-ide
US4500538A (en) * 1983-03-14 1985-02-19 Merck & Co., Inc. Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure
JPS59176270A (en) * 1983-03-17 1984-10-05 メルク・エンド・カムパニ−・インコ−ポレ−テツド Benzothiazole-2-sulfonamide derivative for locally treating intraocular pressure rise
US4499103A (en) * 1983-03-17 1985-02-12 Merck & Co., Inc. Benzothiazole-2-sulfonamide derivatives for the topical treatment of elevated intraocular pressure
US4456599A (en) * 1983-04-22 1984-06-26 Merck & Co., Inc. Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure
US4470991A (en) * 1983-04-22 1984-09-11 Merck & Co., Inc. Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure
US4472418A (en) * 1983-04-22 1984-09-18 Merck & Co., Inc. Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure
US4472417A (en) * 1983-04-22 1984-09-18 Merck & Co., Inc. Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure
KR100351743B1 (en) * 1999-11-12 2002-09-11 미원상사주식회사 Process for preparation of the n,n-dicyclohexyl-2-benzothiazole sulfenamide
KR20030084444A (en) * 2002-04-26 2003-11-01 주식회사 파나진 A Novel Monomer For Synthesis of PNA Oligomer And A Process For Producing The Same

Also Published As

Publication number Publication date
JPS5827273B2 (en) 1983-06-08

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