JPS55124781A - 1,4-benzdioxanesulfonamide derivative - Google Patents

1,4-benzdioxanesulfonamide derivative

Info

Publication number
JPS55124781A
JPS55124781A JP3291579A JP3291579A JPS55124781A JP S55124781 A JPS55124781 A JP S55124781A JP 3291579 A JP3291579 A JP 3291579A JP 3291579 A JP3291579 A JP 3291579A JP S55124781 A JPS55124781 A JP S55124781A
Authority
JP
Japan
Prior art keywords
halogen
formula
benzdioxanesulfonamide
derivative
hypotensive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP3291579A
Other languages
Japanese (ja)
Inventor
Hiroshi Itazaki
Akiko Kawasaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Priority to JP3291579A priority Critical patent/JPS55124781A/en
Publication of JPS55124781A publication Critical patent/JPS55124781A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:A 1,4-benzdioxanesulfonamide derivative of formula I [R is exomethylene group, CH2X (X is H, halogen, OH, etc.), or COY (Y is OH, hologen, alkoxy group, etc.); R' is H, halogen, or aryloxy group; R2 is H or halogen].
EXAMPLE: 2-Hydroxymethyl-7-chloro-1, 4-benzdioxane-6-sulfonamide.
USE: Hypotensive agents having almost the same hypotensive action as Trichlormethiazide which is a diuretic hypotensive agent.
PROCESS: A compound of formula II is reduced catalytically to form a compound of formula III, which is diazotized to give a diazonium salt. The salt is then subjected to the modified Sandmeyer reaction to afford a sulfonyl chloride, which is reacted with conc. ammonium hydroxide to yield the compounds of formulas Ia and Ib.
COPYRIGHT: (C)1980,JPO&Japio
JP3291579A 1979-03-20 1979-03-20 1,4-benzdioxanesulfonamide derivative Pending JPS55124781A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3291579A JPS55124781A (en) 1979-03-20 1979-03-20 1,4-benzdioxanesulfonamide derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3291579A JPS55124781A (en) 1979-03-20 1979-03-20 1,4-benzdioxanesulfonamide derivative

Publications (1)

Publication Number Publication Date
JPS55124781A true JPS55124781A (en) 1980-09-26

Family

ID=12372185

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3291579A Pending JPS55124781A (en) 1979-03-20 1979-03-20 1,4-benzdioxanesulfonamide derivative

Country Status (1)

Country Link
JP (1) JPS55124781A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0182302A2 (en) * 1984-11-14 1986-05-28 Shionogi & Co., Ltd. Novel 1,4-benzodioxane and 1,4-benzodioxine derivatives and production thereof
US20110105461A1 (en) * 2008-04-29 2011-05-05 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Modulators of dopamine neurotransmission
CN102285878A (en) * 2011-06-24 2011-12-21 昆明制药集团股份有限公司 Method for preparing 2-halo-4,5-dimethoxy benzoic acid

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0182302A2 (en) * 1984-11-14 1986-05-28 Shionogi & Co., Ltd. Novel 1,4-benzodioxane and 1,4-benzodioxine derivatives and production thereof
EP0182302A3 (en) * 1984-11-14 1987-04-01 Shionogi & Co., Ltd. Novel 1,4-benzodioxane and 1,4-benzodioxine derivatives and production thereof
US20110105461A1 (en) * 2008-04-29 2011-05-05 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Modulators of dopamine neurotransmission
US8524766B2 (en) * 2008-04-29 2013-09-03 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Modulators of dopamine neurotransmission
CN102285878A (en) * 2011-06-24 2011-12-21 昆明制药集团股份有限公司 Method for preparing 2-halo-4,5-dimethoxy benzoic acid

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