JPS5655371A - Quinoline derivative - Google Patents

Quinoline derivative

Info

Publication number
JPS5655371A
JPS5655371A JP13162979A JP13162979A JPS5655371A JP S5655371 A JPS5655371 A JP S5655371A JP 13162979 A JP13162979 A JP 13162979A JP 13162979 A JP13162979 A JP 13162979A JP S5655371 A JPS5655371 A JP S5655371A
Authority
JP
Japan
Prior art keywords
formula
compound
halogen
quinoline derivative
affords
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP13162979A
Other languages
Japanese (ja)
Other versions
JPS6361941B2 (en
Inventor
Hiroshi Ishikawa
Fujio Tafusa
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP13162979A priority Critical patent/JPS5655371A/en
Publication of JPS5655371A publication Critical patent/JPS5655371A/en
Publication of JPS6361941B2 publication Critical patent/JPS6361941B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

NEW MATERIAL:A quinoline derivative of formula I (R1 is lower alkyl; R2 is halogen, nitro, amino, or lower alkanoylamino; R3 is halogen or hydroxy) and its salt.
EXAMPLE: 5-Nitro-6-chloroquinaldine.
USE: An antimicrobial agent and antimalarial agent. A synthetic intermediate of the compounds of formula II and formula III useful as antimicrobial agents.
PROCESS: For example, nitration of a compound of formula 2 (X1 is halogen) affords the compound of formula Ia, which can be converted to the compound of formula Ib by substituting the halogen atom with hydroxy group. Reduction of the compounds of formula Ia and I b gives the compound of formula Ic, which is converted to the compound of formula Id (R4 is H or alkyl) by the lower alkanoylation of the amino group of the compound of formula Ic. The halogen-substitution reaction of the amino group of the compound of formula Ic affords the compound of formula Ie.
COPYRIGHT: (C)1981,JPO&Japio
JP13162979A 1979-10-11 1979-10-11 Quinoline derivative Granted JPS5655371A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP13162979A JPS5655371A (en) 1979-10-11 1979-10-11 Quinoline derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13162979A JPS5655371A (en) 1979-10-11 1979-10-11 Quinoline derivative

Publications (2)

Publication Number Publication Date
JPS5655371A true JPS5655371A (en) 1981-05-15
JPS6361941B2 JPS6361941B2 (en) 1988-11-30

Family

ID=15062509

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13162979A Granted JPS5655371A (en) 1979-10-11 1979-10-11 Quinoline derivative

Country Status (1)

Country Link
JP (1) JPS5655371A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57193459A (en) * 1981-05-22 1982-11-27 Otsuka Pharmaceut Co Ltd Quinoline derivative

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5445338A (en) * 1977-09-19 1979-04-10 Nippon Chem Ind Co Ltd:The Production of quinophthalone pigment

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5445338A (en) * 1977-09-19 1979-04-10 Nippon Chem Ind Co Ltd:The Production of quinophthalone pigment

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57193459A (en) * 1981-05-22 1982-11-27 Otsuka Pharmaceut Co Ltd Quinoline derivative
JPH0154344B2 (en) * 1981-05-22 1989-11-17 Otsuka Pharma Co Ltd

Also Published As

Publication number Publication date
JPS6361941B2 (en) 1988-11-30

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