JPS5610150A - Preparation of nitrotoluene derivative - Google Patents
Preparation of nitrotoluene derivativeInfo
- Publication number
- JPS5610150A JPS5610150A JP8505879A JP8505879A JPS5610150A JP S5610150 A JPS5610150 A JP S5610150A JP 8505879 A JP8505879 A JP 8505879A JP 8505879 A JP8505879 A JP 8505879A JP S5610150 A JPS5610150 A JP S5610150A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- nitrotoluene derivative
- preparation
- group shown
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To obtain advantageously the titled compound useful as a drug, its intermediate, especially a β-adrenergic neuronal blocking agent, by reacting a specific 6- substituted-2-nitrotoluene derivative with a primary amine.
CONSTITUTION: A compound shown by the formula I [Z is a group shown by the formula II or III (X is halogen)] is reacted with a compound shown by the formula IV (R is alkyl) preferably at 30W220°C to give a nitrotoluene derivative shown by the formula V. When a compound in case that Z is the group shown by the formula II is used, the reaction can be carried out in the presence of a hydrohalogenic acid and when a compound in case that Z is the group shown by the formula III is used, the reaction can be carried out in the presence of a base.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8505879A JPS5610150A (en) | 1979-07-06 | 1979-07-06 | Preparation of nitrotoluene derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8505879A JPS5610150A (en) | 1979-07-06 | 1979-07-06 | Preparation of nitrotoluene derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5610150A true JPS5610150A (en) | 1981-02-02 |
Family
ID=13848029
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8505879A Pending JPS5610150A (en) | 1979-07-06 | 1979-07-06 | Preparation of nitrotoluene derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5610150A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5823652A (en) * | 1981-08-03 | 1983-02-12 | Paamakemu Asia:Kk | Novel optical active(r)-(+)-6-(2-hydroxy-3- alkylaminopropoxy)-2-nitrotoluene and its preparation |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4929182A (en) * | 1972-07-07 | 1974-03-15 | ||
| JPS4930819A (en) * | 1972-07-21 | 1974-03-19 | ||
| JPS5037182A (en) * | 1973-08-08 | 1975-04-07 | ||
| JPS5141623A (en) * | 1974-10-05 | 1976-04-08 | Nippon Steel Corp | Renzokushodonnyoru nanshitsunahyomenshoryokohanno seizoho |
| JPS5220457A (en) * | 1975-08-08 | 1977-02-16 | Noboru Maruyama | Liquid heating apparatus |
-
1979
- 1979-07-06 JP JP8505879A patent/JPS5610150A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4929182A (en) * | 1972-07-07 | 1974-03-15 | ||
| JPS4930819A (en) * | 1972-07-21 | 1974-03-19 | ||
| JPS5037182A (en) * | 1973-08-08 | 1975-04-07 | ||
| JPS5141623A (en) * | 1974-10-05 | 1976-04-08 | Nippon Steel Corp | Renzokushodonnyoru nanshitsunahyomenshoryokohanno seizoho |
| JPS5220457A (en) * | 1975-08-08 | 1977-02-16 | Noboru Maruyama | Liquid heating apparatus |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5823652A (en) * | 1981-08-03 | 1983-02-12 | Paamakemu Asia:Kk | Novel optical active(r)-(+)-6-(2-hydroxy-3- alkylaminopropoxy)-2-nitrotoluene and its preparation |
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