JPS57118555A - Leucotriene-analog compound, its preparation, and leucotriene-biosynthesis inhibiting agent containing said compound as active component - Google Patents

Leucotriene-analog compound, its preparation, and leucotriene-biosynthesis inhibiting agent containing said compound as active component

Info

Publication number
JPS57118555A
JPS57118555A JP356381A JP356381A JPS57118555A JP S57118555 A JPS57118555 A JP S57118555A JP 356381 A JP356381 A JP 356381A JP 356381 A JP356381 A JP 356381A JP S57118555 A JPS57118555 A JP S57118555A
Authority
JP
Japan
Prior art keywords
compound
leucotriene
alkyl
preparation
active component
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP356381A
Other languages
Japanese (ja)
Inventor
Yoshinobu Arai
Shigehiro Okuyama
Akira Doi
Tsumoru Miyamoto
Masaki Hayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Priority to JP356381A priority Critical patent/JPS57118555A/en
Publication of JPS57118555A publication Critical patent/JPS57118555A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:The compound of formulaI[R1 is H or 1W5C alkyl; R2 is 6W10C alkyl; R3 is 1W8C alkyl or group of formula II (n is 0 or 1W4; Y is H, halogen, OH or amino); m is 2W4] or non-toxic salt of the acid (when R1 is H).
EXAMPLE: 5S-Hydroxy-6R-benzylthio-7,9,11-trans-14-cis-eicosatetraenoic acid.
USE: Agent for inhibiting the biosynthesis of leucotriene. Useful for the prevention and remedy of various allergic diseases caused by leucotriene.
PROCESS: The compound of formulaI(wherein R1 is 1W5C alkyl) is prepared by reacting the compound of formula III with the compound of formula HS-R3 in a solvent such as methanol in the presence of a base such as triethylamine.
COPYRIGHT: (C)1982,JPO&Japio
JP356381A 1981-01-13 1981-01-13 Leucotriene-analog compound, its preparation, and leucotriene-biosynthesis inhibiting agent containing said compound as active component Pending JPS57118555A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP356381A JPS57118555A (en) 1981-01-13 1981-01-13 Leucotriene-analog compound, its preparation, and leucotriene-biosynthesis inhibiting agent containing said compound as active component

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP356381A JPS57118555A (en) 1981-01-13 1981-01-13 Leucotriene-analog compound, its preparation, and leucotriene-biosynthesis inhibiting agent containing said compound as active component

Publications (1)

Publication Number Publication Date
JPS57118555A true JPS57118555A (en) 1982-07-23

Family

ID=11560886

Family Applications (1)

Application Number Title Priority Date Filing Date
JP356381A Pending JPS57118555A (en) 1981-01-13 1981-01-13 Leucotriene-analog compound, its preparation, and leucotriene-biosynthesis inhibiting agent containing said compound as active component

Country Status (1)

Country Link
JP (1) JPS57118555A (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4513005A (en) * 1981-06-18 1985-04-23 Lilly Industries Limited SRS-A antagonists
US4537723A (en) * 1982-02-04 1985-08-27 The Upjohn Company Derivatives of leukotrienes A and C
US4609744A (en) * 1983-04-21 1986-09-02 Merck Frosst Canada Inc. 4-oxo-benzopyran carboxylic acids
US4758594A (en) * 1984-07-18 1988-07-19 Schering Corporation Inhibitors of slow reacting substance of anaphylaxis
US4798842A (en) * 1984-07-18 1989-01-17 Schering Corporation Inhibitors of slow reacting substance of anaphylaxis
US4889873A (en) * 1984-07-18 1989-12-26 Schering Corporation Inhibitors of slow reacting substance of anaphylaxis
US4988716A (en) * 1984-07-18 1991-01-29 Schering Corporation Inhibitors of slow reacting substance of anaphylaxis
US5017583A (en) * 1983-04-21 1991-05-21 Merck Frosst Canada, Inc. Leukotriene antagonists

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4513005A (en) * 1981-06-18 1985-04-23 Lilly Industries Limited SRS-A antagonists
US4537723A (en) * 1982-02-04 1985-08-27 The Upjohn Company Derivatives of leukotrienes A and C
US4609744A (en) * 1983-04-21 1986-09-02 Merck Frosst Canada Inc. 4-oxo-benzopyran carboxylic acids
US5017583A (en) * 1983-04-21 1991-05-21 Merck Frosst Canada, Inc. Leukotriene antagonists
US4758594A (en) * 1984-07-18 1988-07-19 Schering Corporation Inhibitors of slow reacting substance of anaphylaxis
US4798842A (en) * 1984-07-18 1989-01-17 Schering Corporation Inhibitors of slow reacting substance of anaphylaxis
US4889873A (en) * 1984-07-18 1989-12-26 Schering Corporation Inhibitors of slow reacting substance of anaphylaxis
US4988716A (en) * 1984-07-18 1991-01-29 Schering Corporation Inhibitors of slow reacting substance of anaphylaxis

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