JPS57144254A - 2-substituted-2-oxoazetidine derivative and its preparation - Google Patents

2-substituted-2-oxoazetidine derivative and its preparation

Info

Publication number
JPS57144254A
JPS57144254A JP56029387A JP2938781A JPS57144254A JP S57144254 A JPS57144254 A JP S57144254A JP 56029387 A JP56029387 A JP 56029387A JP 2938781 A JP2938781 A JP 2938781A JP S57144254 A JPS57144254 A JP S57144254A
Authority
JP
Japan
Prior art keywords
substituted
oxoazetidine
derivative
aryl
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP56029387A
Other languages
Japanese (ja)
Inventor
Daiei Tsunemoto
Masaaki Kakimoto
Sei Kondo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sagami Chemical Research Institute
Original Assignee
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sagami Chemical Research Institute filed Critical Sagami Chemical Research Institute
Priority to JP56029387A priority Critical patent/JPS57144254A/en
Publication of JPS57144254A publication Critical patent/JPS57144254A/en
Pending legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:The N-substituted-2-oxoazetidine derivative of formulaI(R1 is H, alkoxy, aryloxy, alkylthio, arylthio, halogen, acyloxy, azido or amino; Ar is aromatic group; R2 is H, alkyl, aryl, alkylsilyl or a salt-forming metal cation).
EXAMPLE: β-(4-Methylthio-2-oxoazetidine-1-yl)-cinnamic acid methyl ester.
USE: Antibiotic agent and β-lactamase-inhibiting agent.
PROCESS: The compound of formulaIcan be prepared by reacting the 2-oxoazetidine derivative of formula II with the substituted sulfinylacrylic acid derivative of formula III (R3 is alkyl or aryl) in the presence of a base such as alkali metal hydride.
COPYRIGHT: (C)1982,JPO&Japio
JP56029387A 1981-03-03 1981-03-03 2-substituted-2-oxoazetidine derivative and its preparation Pending JPS57144254A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP56029387A JPS57144254A (en) 1981-03-03 1981-03-03 2-substituted-2-oxoazetidine derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56029387A JPS57144254A (en) 1981-03-03 1981-03-03 2-substituted-2-oxoazetidine derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS57144254A true JPS57144254A (en) 1982-09-06

Family

ID=12274721

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56029387A Pending JPS57144254A (en) 1981-03-03 1981-03-03 2-substituted-2-oxoazetidine derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS57144254A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5944355A (en) * 1982-09-03 1984-03-12 Takeda Chem Ind Ltd 2-azetidinone derivative and its preparation
JPH075513B2 (en) * 1990-06-14 1995-01-25 ファイザー・インコーポレーテッド 3-Aryl-2-hydroxypropionic acid derivatives and homologues as hypoglycemic agents

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5944355A (en) * 1982-09-03 1984-03-12 Takeda Chem Ind Ltd 2-azetidinone derivative and its preparation
JPH0321026B2 (en) * 1982-09-03 1991-03-20 Takeda Chemical Industries Ltd
JPH075513B2 (en) * 1990-06-14 1995-01-25 ファイザー・インコーポレーテッド 3-Aryl-2-hydroxypropionic acid derivatives and homologues as hypoglycemic agents

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