JPS57169489A - Cephalosporin derivative and its preparation - Google Patents

Cephalosporin derivative and its preparation

Info

Publication number
JPS57169489A
JPS57169489A JP5523181A JP5523181A JPS57169489A JP S57169489 A JPS57169489 A JP S57169489A JP 5523181 A JP5523181 A JP 5523181A JP 5523181 A JP5523181 A JP 5523181A JP S57169489 A JPS57169489 A JP S57169489A
Authority
JP
Japan
Prior art keywords
compound
formula
preparation
formulai
hydroxyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP5523181A
Other languages
Japanese (ja)
Other versions
JPS611074B2 (en
Inventor
Hideo Nakao
Koichi Fujimoto
Sadao Ishihara
Shinichi Sugawara
Isamu Igarashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP5523181A priority Critical patent/JPS57169489A/en
Priority to US06/304,988 priority patent/US4486425A/en
Priority to AT81304415T priority patent/ATE19403T1/en
Priority to EP81304415A priority patent/EP0049118B1/en
Priority to DE8181304415T priority patent/DE3174472D1/en
Priority to PH26288A priority patent/PH18740A/en
Priority to AU75781/81A priority patent/AU547984B2/en
Priority to CA000387048A priority patent/CA1171404A/en
Priority to IE2273/81A priority patent/IE53177B1/en
Priority to FI813038A priority patent/FI73440C/en
Priority to ES505923A priority patent/ES505923A0/en
Priority to KR1019810003696A priority patent/KR870000848B1/en
Priority to ES514993A priority patent/ES8306158A1/en
Priority to ES514995A priority patent/ES8306759A1/en
Priority to ES514994A priority patent/ES514994A0/en
Publication of JPS57169489A publication Critical patent/JPS57169489A/en
Publication of JPS611074B2 publication Critical patent/JPS611074B2/ja
Priority to US06/873,114 priority patent/US4716158A/en
Priority to MX9203566A priority patent/MX174340B/en
Priority to NL930098C priority patent/NL930098I2/en
Granted legal-status Critical Current

Links

Landscapes

  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:A compound of formulaI[R1 is phenyl, which may be substituted; R2 is lower alkyl, R3 is H, halogen, hydroxyl, lower alkoxy, -CH2R5 (R5 is H, hydroxyl, lower alkoxy); COOR4 is carboxyl, which may be esterified].
EXAMPLE: 7-( 4-p-Toluenesulfonyloxy-3-oxo-2-methoxyiminobutyrylamino )-3-cephem-4-carboxylic acid.
USE: Synthetic intermediate of a compound of formula II, which is used as an antibacterial.
PREPARATION: The reaction of a novel compound of formula III or its reactive derivative with modified carboxyl group such as acid halide with a compound of formula IV gives the compound of formulaI. Thiourea is made to act on the compound of formulaIto give a syn-type compound of formula II in high yield.
COPYRIGHT: (C)1982,JPO&Japio
JP5523181A 1980-09-30 1981-04-13 Cephalosporin derivative and its preparation Granted JPS57169489A (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
JP5523181A JPS57169489A (en) 1981-04-13 1981-04-13 Cephalosporin derivative and its preparation
US06/304,988 US4486425A (en) 1980-09-30 1981-09-23 7-[2-(2-Aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido]-3-methoxymethyl-3-cephem-4-carboxylates
AT81304415T ATE19403T1 (en) 1980-09-30 1981-09-24 CEPHALOSPORIN COMPOUNDS, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM.
EP81304415A EP0049118B1 (en) 1980-09-30 1981-09-24 Cephalosporin derivatives, their preparation and compositions containing them
DE8181304415T DE3174472D1 (en) 1980-09-30 1981-09-24 Cephalosporin derivatives, their preparation and compositions containing them
PH26288A PH18740A (en) 1980-09-30 1981-09-29 Cephalosporin derivatives and composition containing them
FI813038A FI73440C (en) 1980-09-30 1981-09-30 Process for the preparation of the drug useful alkyl (or alkoxy) carbonyloxyalkyl-7- / 2- (aminothiazol-4-yl) -2-methoxy- (or ethoxyl) iminoacetamido / -3-methoxymethyl-3- cephem-4-carboxylate.
CA000387048A CA1171404A (en) 1980-09-30 1981-09-30 Cephalosporin derivatives, their preparation and compositions containing them
IE2273/81A IE53177B1 (en) 1980-09-30 1981-09-30 Cephalosporin derivatives,their preparation and compositions containing them
AU75781/81A AU547984B2 (en) 1980-09-30 1981-09-30 Cephalosporin derivatives
ES505923A ES505923A0 (en) 1980-09-30 1981-09-30 A PROCEDURE FOR THE PREPARATION OF NEW CEPHALOSPORIN DERIVATIVES.
KR1019810003696A KR870000848B1 (en) 1980-09-30 1981-09-30 Process for preparing cephalosporin derivatives
ES514995A ES8306759A1 (en) 1980-09-30 1982-08-13 Cephalosporin derivatives, their preparation and compositions containing them.
ES514993A ES8306158A1 (en) 1980-09-30 1982-08-13 Cephalosporin derivatives, their preparation and compositions containing them.
ES514994A ES514994A0 (en) 1980-09-30 1982-08-13 A PROCEDURE FOR THE PREPARATION OF NEW CEPHALOSPORIN DERIVATIVES.
US06/873,114 US4716158A (en) 1980-09-30 1986-06-10 7-(2-aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido)-3-methoxymethyl-3-cepham-4-carboxylates
MX9203566A MX174340B (en) 1980-09-30 1992-06-26 3-CEFEM-4-CARBOXYLATES OF 7- (2- (2-AMINOTIAZOL-4-IL) -2- (SIN) -METOXIIMINO-ACETAMIDO) -3-METOXIMETILO
NL930098C NL930098I2 (en) 1980-09-30 1993-06-25 Cephalosporin compounds, their preparation and compositions containing them.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5523181A JPS57169489A (en) 1981-04-13 1981-04-13 Cephalosporin derivative and its preparation

Related Child Applications (3)

Application Number Title Priority Date Filing Date
JP10234785A Division JPS60260583A (en) 1985-05-14 1985-05-14 Preparation of cephalosporin derivative
JP10234885A Division JPS6163A (en) 1985-05-14 1985-05-14 2-alkoxyiminobutyric acid derivative
JP10234985A Division JPS60260584A (en) 1985-05-14 1985-05-14 Cephalosporin derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS57169489A true JPS57169489A (en) 1982-10-19
JPS611074B2 JPS611074B2 (en) 1986-01-13

Family

ID=12992825

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5523181A Granted JPS57169489A (en) 1980-09-30 1981-04-13 Cephalosporin derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS57169489A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS604190A (en) * 1983-06-21 1985-01-10 Sankyo Co Ltd Preparation of cephalosporin derivative

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS604190A (en) * 1983-06-21 1985-01-10 Sankyo Co Ltd Preparation of cephalosporin derivative

Also Published As

Publication number Publication date
JPS611074B2 (en) 1986-01-13

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