JPS57169489A - Cephalosporin derivative and its preparation - Google Patents
Cephalosporin derivative and its preparationInfo
- Publication number
- JPS57169489A JPS57169489A JP5523181A JP5523181A JPS57169489A JP S57169489 A JPS57169489 A JP S57169489A JP 5523181 A JP5523181 A JP 5523181A JP 5523181 A JP5523181 A JP 5523181A JP S57169489 A JPS57169489 A JP S57169489A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- preparation
- formulai
- hydroxyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:A compound of formulaI[R1 is phenyl, which may be substituted; R2 is lower alkyl, R3 is H, halogen, hydroxyl, lower alkoxy, -CH2R5 (R5 is H, hydroxyl, lower alkoxy); COOR4 is carboxyl, which may be esterified].
EXAMPLE: 7-( 4-p-Toluenesulfonyloxy-3-oxo-2-methoxyiminobutyrylamino )-3-cephem-4-carboxylic acid.
USE: Synthetic intermediate of a compound of formula II, which is used as an antibacterial.
PREPARATION: The reaction of a novel compound of formula III or its reactive derivative with modified carboxyl group such as acid halide with a compound of formula IV gives the compound of formulaI. Thiourea is made to act on the compound of formulaIto give a syn-type compound of formula II in high yield.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5523181A JPS57169489A (en) | 1981-04-13 | 1981-04-13 | Cephalosporin derivative and its preparation |
US06/304,988 US4486425A (en) | 1980-09-30 | 1981-09-23 | 7-[2-(2-Aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido]-3-methoxymethyl-3-cephem-4-carboxylates |
AT81304415T ATE19403T1 (en) | 1980-09-30 | 1981-09-24 | CEPHALOSPORIN COMPOUNDS, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM. |
EP81304415A EP0049118B1 (en) | 1980-09-30 | 1981-09-24 | Cephalosporin derivatives, their preparation and compositions containing them |
DE8181304415T DE3174472D1 (en) | 1980-09-30 | 1981-09-24 | Cephalosporin derivatives, their preparation and compositions containing them |
PH26288A PH18740A (en) | 1980-09-30 | 1981-09-29 | Cephalosporin derivatives and composition containing them |
FI813038A FI73440C (en) | 1980-09-30 | 1981-09-30 | Process for the preparation of the drug useful alkyl (or alkoxy) carbonyloxyalkyl-7- / 2- (aminothiazol-4-yl) -2-methoxy- (or ethoxyl) iminoacetamido / -3-methoxymethyl-3- cephem-4-carboxylate. |
CA000387048A CA1171404A (en) | 1980-09-30 | 1981-09-30 | Cephalosporin derivatives, their preparation and compositions containing them |
IE2273/81A IE53177B1 (en) | 1980-09-30 | 1981-09-30 | Cephalosporin derivatives,their preparation and compositions containing them |
AU75781/81A AU547984B2 (en) | 1980-09-30 | 1981-09-30 | Cephalosporin derivatives |
ES505923A ES505923A0 (en) | 1980-09-30 | 1981-09-30 | A PROCEDURE FOR THE PREPARATION OF NEW CEPHALOSPORIN DERIVATIVES. |
KR1019810003696A KR870000848B1 (en) | 1980-09-30 | 1981-09-30 | Process for preparing cephalosporin derivatives |
ES514995A ES8306759A1 (en) | 1980-09-30 | 1982-08-13 | Cephalosporin derivatives, their preparation and compositions containing them. |
ES514993A ES8306158A1 (en) | 1980-09-30 | 1982-08-13 | Cephalosporin derivatives, their preparation and compositions containing them. |
ES514994A ES514994A0 (en) | 1980-09-30 | 1982-08-13 | A PROCEDURE FOR THE PREPARATION OF NEW CEPHALOSPORIN DERIVATIVES. |
US06/873,114 US4716158A (en) | 1980-09-30 | 1986-06-10 | 7-(2-aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido)-3-methoxymethyl-3-cepham-4-carboxylates |
MX9203566A MX174340B (en) | 1980-09-30 | 1992-06-26 | 3-CEFEM-4-CARBOXYLATES OF 7- (2- (2-AMINOTIAZOL-4-IL) -2- (SIN) -METOXIIMINO-ACETAMIDO) -3-METOXIMETILO |
NL930098C NL930098I2 (en) | 1980-09-30 | 1993-06-25 | Cephalosporin compounds, their preparation and compositions containing them. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5523181A JPS57169489A (en) | 1981-04-13 | 1981-04-13 | Cephalosporin derivative and its preparation |
Related Child Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10234785A Division JPS60260583A (en) | 1985-05-14 | 1985-05-14 | Preparation of cephalosporin derivative |
JP10234885A Division JPS6163A (en) | 1985-05-14 | 1985-05-14 | 2-alkoxyiminobutyric acid derivative |
JP10234985A Division JPS60260584A (en) | 1985-05-14 | 1985-05-14 | Cephalosporin derivative and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57169489A true JPS57169489A (en) | 1982-10-19 |
JPS611074B2 JPS611074B2 (en) | 1986-01-13 |
Family
ID=12992825
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP5523181A Granted JPS57169489A (en) | 1980-09-30 | 1981-04-13 | Cephalosporin derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57169489A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS604190A (en) * | 1983-06-21 | 1985-01-10 | Sankyo Co Ltd | Preparation of cephalosporin derivative |
-
1981
- 1981-04-13 JP JP5523181A patent/JPS57169489A/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS604190A (en) * | 1983-06-21 | 1985-01-10 | Sankyo Co Ltd | Preparation of cephalosporin derivative |
Also Published As
Publication number | Publication date |
---|---|
JPS611074B2 (en) | 1986-01-13 |
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