JPS57165390A - Novel penicillin and cephalosporin derivative - Google Patents

Novel penicillin and cephalosporin derivative

Info

Publication number
JPS57165390A
JPS57165390A JP4843881A JP4843881A JPS57165390A JP S57165390 A JPS57165390 A JP S57165390A JP 4843881 A JP4843881 A JP 4843881A JP 4843881 A JP4843881 A JP 4843881A JP S57165390 A JPS57165390 A JP S57165390A
Authority
JP
Japan
Prior art keywords
compound
formula
salt
acyloxy
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4843881A
Other languages
Japanese (ja)
Inventor
Yoshimasa Machida
Isao Saito
Shigeto Negi
Isao Sugiyama
Seiichiro Nomoto
Hironori Ikuta
Hiroshi Yamauchi
Kyosuke Kito
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Priority to JP4843881A priority Critical patent/JPS57165390A/en
Priority to US06/363,778 priority patent/US4468394A/en
Priority to EP82102830A priority patent/EP0062328A3/en
Publication of JPS57165390A publication Critical patent/JPS57165390A/en
Pending legal-status Critical Current

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  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:The compound of formulaI[R1 is H or methoxy; R2 is H or OH; R3 and R4 are OH or acyloxy; Y is O, S or >N-R5 (R5 is H or lower alkyl); X is group of formula II or formula III (R6 is acyloxy or N-containing heterocyclic-thio which may have substituent group)], its non-toxic salt and its carboxylic acid ester.
EXAMPLE: 6β-[ D-2-( 6,7-Diacetoxy-2-oxo-2H-1-benzopyran-3-carboxamido )-2- phenylacetamido]-penicillanic acid.
USE: Antibacterial agent having extremely strong antibacterial activity especially against Pseudomonas aeruginosa and Klebsiella pneumoniae.
PROCESS: The compound of formulaIis prepared by reacting the compound of formula IV, its salt or its hydrate with the compound of formula V or its reactive derivative (e.g. acid halide, symmetric acid anhydride, etc.), and if necessary, converting the product to the salt or ester.
COPYRIGHT: (C)1982,JPO&Japio
JP4843881A 1981-04-02 1981-04-02 Novel penicillin and cephalosporin derivative Pending JPS57165390A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP4843881A JPS57165390A (en) 1981-04-02 1981-04-02 Novel penicillin and cephalosporin derivative
US06/363,778 US4468394A (en) 1981-04-02 1982-03-31 Cephalosporin compounds
EP82102830A EP0062328A3 (en) 1981-04-02 1982-04-02 Novel penicillin and cephalosporin compounds, a process for preparing the same and antibacterial composition containing the novel compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4843881A JPS57165390A (en) 1981-04-02 1981-04-02 Novel penicillin and cephalosporin derivative

Publications (1)

Publication Number Publication Date
JPS57165390A true JPS57165390A (en) 1982-10-12

Family

ID=12803350

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4843881A Pending JPS57165390A (en) 1981-04-02 1981-04-02 Novel penicillin and cephalosporin derivative

Country Status (1)

Country Link
JP (1) JPS57165390A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5244892A (en) * 1990-10-16 1993-09-14 Kyorin Pharmaceutical Co., Ltd. Cephem compounds, and antibacterial agents

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5244892A (en) * 1990-10-16 1993-09-14 Kyorin Pharmaceutical Co., Ltd. Cephem compounds, and antibacterial agents

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