JPS5791990A - 7alpha-methoxycephem derivative, its preparation and antimicrobial agent consisting of the same - Google Patents

7alpha-methoxycephem derivative, its preparation and antimicrobial agent consisting of the same

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Publication number
JPS5791990A
JPS5791990A JP16737180A JP16737180A JPS5791990A JP S5791990 A JPS5791990 A JP S5791990A JP 16737180 A JP16737180 A JP 16737180A JP 16737180 A JP16737180 A JP 16737180A JP S5791990 A JPS5791990 A JP S5791990A
Authority
JP
Japan
Prior art keywords
compound
antimicrobial agent
formulai
derivative
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP16737180A
Other languages
Japanese (ja)
Inventor
Yoshimasa Machida
Isao Saito
Seiichiro Nomoto
Shigeto Negi
Hironori Ikuta
Kyosuke Kito
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Priority to JP16737180A priority Critical patent/JPS5791990A/en
Publication of JPS5791990A publication Critical patent/JPS5791990A/en
Pending legal-status Critical Current

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  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound of formulaI(R1 is H or hydroxyl group; R2 is lower alkyl or chlorine-substituted lower alkyl; R3 is acyloxy or heterocyclic thio group containing nitrogen) and a nontoxic salt thereof.
EXAMPLE: 7β-[D-2-[6,7-Bis(ethoxycarbonyloxy)chromone-3-carboxamido]2-(4- hydroxyphenyl)acetamido]-7α-methoxy-3-(1-methoxycarbonylmethyl-5-tetrazolyl) thiomethyl-3-cephem-4-carboxylic acid.
USE: An antimicrobial agent effective against Gram-positive and Gram-negative bacteria, particularly clinically intractable bacteria, e.g. Proteus morganii, and germs capable of producing β-lactamase.
PROCESS: A compound of formula II or a salt thereof is reacted with a compound of formula III or a reactive derivative thereof, e.g. an acid chloride, in an inert solvent, in the presence or absence of a basic reagent or silylating agent to give the compound of formulaI.
COPYRIGHT: (C)1982,JPO&Japio
JP16737180A 1980-11-29 1980-11-29 7alpha-methoxycephem derivative, its preparation and antimicrobial agent consisting of the same Pending JPS5791990A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP16737180A JPS5791990A (en) 1980-11-29 1980-11-29 7alpha-methoxycephem derivative, its preparation and antimicrobial agent consisting of the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP16737180A JPS5791990A (en) 1980-11-29 1980-11-29 7alpha-methoxycephem derivative, its preparation and antimicrobial agent consisting of the same

Publications (1)

Publication Number Publication Date
JPS5791990A true JPS5791990A (en) 1982-06-08

Family

ID=15848466

Family Applications (1)

Application Number Title Priority Date Filing Date
JP16737180A Pending JPS5791990A (en) 1980-11-29 1980-11-29 7alpha-methoxycephem derivative, its preparation and antimicrobial agent consisting of the same

Country Status (1)

Country Link
JP (1) JPS5791990A (en)

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