JPS57109792A - Penicillin derivative and salt thereof - Google Patents

Penicillin derivative and salt thereof

Info

Publication number
JPS57109792A
JPS57109792A JP18400680A JP18400680A JPS57109792A JP S57109792 A JPS57109792 A JP S57109792A JP 18400680 A JP18400680 A JP 18400680A JP 18400680 A JP18400680 A JP 18400680A JP S57109792 A JPS57109792 A JP S57109792A
Authority
JP
Japan
Prior art keywords
salt
formulai
gram
compound
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP18400680A
Other languages
Japanese (ja)
Inventor
Shuichi Iwadare
Ryosuke Ushijima
Hiroshi Fukatsu
Fumio Nakano
Takashi Mitomo
Susumu Nakagawa
Hideo Takeda
Ikuo Iwatsuki
Ikuo Matsumoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD KK
Original Assignee
Banyu Phamaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Phamaceutical Co Ltd filed Critical Banyu Phamaceutical Co Ltd
Priority to JP18400680A priority Critical patent/JPS57109792A/en
Publication of JPS57109792A publication Critical patent/JPS57109792A/en
Pending legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

NEW MATERIAL:A compound of formulaI(R1 and R2 are H, 1W12C alkyl, aryl or aralkyl; R1 and R2 together may link to form methylene chain or methylene chain which may contain N, O or S; X is H or hydroxyl group) and a nontoxic salt thereof.
EXAMPLE: Sodium 6-{D-α-[5-(N-n-octylcarbamoyl)pyridine-1-oxido-2-ylcarboxamido]-α-phenylacetamido}penicillanate.
USE: An antimicrobial agent, useful for treating microbism, and exhibiting improved antimicrobial action on Gram-positive and Gram-negative bacteria and Pseudomonas aeruginosa and a wide range of antimicrobial spectrum.
PROCESS: A carboxylic acid of formula II or an active carbonyl derivative thereof, e.g. an acid halide, is stirred with a penicillin of formula III or a derivative thereof, e.g. sodium salt, in a solvent at -40W+40°C for 1W10hr to give the compound of formulaI.
COPYRIGHT: (C)1982,JPO&Japio
JP18400680A 1980-12-26 1980-12-26 Penicillin derivative and salt thereof Pending JPS57109792A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP18400680A JPS57109792A (en) 1980-12-26 1980-12-26 Penicillin derivative and salt thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP18400680A JPS57109792A (en) 1980-12-26 1980-12-26 Penicillin derivative and salt thereof

Publications (1)

Publication Number Publication Date
JPS57109792A true JPS57109792A (en) 1982-07-08

Family

ID=16145669

Family Applications (1)

Application Number Title Priority Date Filing Date
JP18400680A Pending JPS57109792A (en) 1980-12-26 1980-12-26 Penicillin derivative and salt thereof

Country Status (1)

Country Link
JP (1) JPS57109792A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0463592A1 (en) * 1990-06-28 1992-01-02 Hoechst Aktiengesellschaft 2,4- and 2,5-substituted pyridine-N-oxides, processes for their preparation and for their utilization
US5260323A (en) * 1990-06-28 1993-11-09 Hoechst Aktiengesellschaft 2,4- and 2,5-substituted pyridine-N-oxides, processes for their preparation and their use

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0463592A1 (en) * 1990-06-28 1992-01-02 Hoechst Aktiengesellschaft 2,4- and 2,5-substituted pyridine-N-oxides, processes for their preparation and for their utilization
JPH04230264A (en) * 1990-06-28 1992-08-19 Hoechst Ag 2,4- and 2,5-substituted pyridine -n-oxides
US5260323A (en) * 1990-06-28 1993-11-09 Hoechst Aktiengesellschaft 2,4- and 2,5-substituted pyridine-N-oxides, processes for their preparation and their use

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