JPS5531044A - Penicillanic acid derivative and its preparation - Google Patents
Penicillanic acid derivative and its preparationInfo
- Publication number
- JPS5531044A JPS5531044A JP10436278A JP10436278A JPS5531044A JP S5531044 A JPS5531044 A JP S5531044A JP 10436278 A JP10436278 A JP 10436278A JP 10436278 A JP10436278 A JP 10436278A JP S5531044 A JPS5531044 A JP S5531044A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- derivative
- penicillanic acid
- reacting
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:A penicillanic acid derivative of formula I (R1 is H, lower alkoxy, lower alkoxycarbonyl, halogen; R2 is H, OH; n is 1W3), or its salt.
EXAMPLE: 6-{α-[ 3-( 2-Hydroxybenzoyl )-1-ureido ]-α-phenylacetamido} penicillanic acid.
USE: An antibacterial agent stable under neutral and acidic conditions, having strong bactericidal activity and low toxicity, and effective to prevent the infection with bacteria.
PROCESS: The compound I is prepared, e.g. by reacting a substituted ureidophenylacetic acid or its reactive derivative with 6-aminopenicillanic acid or its reactive derivative in a solvent such as acetone, etc. The compound II is novel, and prepared, e.g. by reacting the corresponding α-aminophenylacetic acid with the corresponding OH-protected benzoyl isocyanate derivative.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (20)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10436278A JPS5531044A (en) | 1978-08-29 | 1978-08-29 | Penicillanic acid derivative and its preparation |
US06/005,832 US4229348A (en) | 1978-05-26 | 1979-01-23 | Penicillanic acid derivatives |
CA320,106A CA1133896A (en) | 1978-05-26 | 1979-01-23 | Penicillanic acid derivative and process for preparing the same |
DD79210631A DD143259A5 (en) | 1978-05-26 | 1979-01-25 | PROCESS FOR THE PREPARATION OF PENICILLANSAEUREDERIVATES |
HU79CU160A HU176076B (en) | 1978-05-26 | 1979-01-26 | Process for producing 2,2-dimethyl-6-aquare bracket-2-bracket-3-benzoyl-1-ureido-bracket closed-2-phenyl-acetamido-square bracket closed-pename-3-carboxylic acid derivatives |
DK179579A DK179579A (en) | 1978-05-26 | 1979-05-01 | PENICILLANIC ACID DERIVATIVES PROCEDURE FOR THEIR PREPARATION AND THEIR USE |
GB7916058A GB2021576B (en) | 1978-05-26 | 1979-05-09 | Penicillins |
AU46898/79A AU4689879A (en) | 1978-05-26 | 1979-05-09 | Penicillanic acid derivative |
IL57264A IL57264A0 (en) | 1978-05-26 | 1979-05-14 | Penicillanic acid derivatives and process for preparing the same |
NO791687A NO791687L (en) | 1978-05-26 | 1979-05-22 | PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE PENICILLANIC ACID DERIVATIVES |
IT68103/79A IT1120970B (en) | 1978-05-26 | 1979-05-24 | PENICILLANIC ACID DERIVATIVE AND PROCEDURE FOR ITS PREPARATION |
ES480906A ES480906A1 (en) | 1978-05-26 | 1979-05-24 | Procedure for the preparation of a penicilanic acid derivative. (Machine-translation by Google Translate, not legally binding) |
PT69665A PT69665A (en) | 1978-05-26 | 1979-05-24 | PENICILANIC ACID DERIVATIVE AND PROCESS FOR PREPARING THE SAME |
FI791680A FI791680A (en) | 1978-05-26 | 1979-05-25 | PENICILLANSYRADERIVAT OCH FOERFARANDE FOER FRAMSTAELLNING AV DET |
FR7913332A FR2426691A1 (en) | 1978-05-26 | 1979-05-25 | PENICILLANIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
NL7904112BA NL7904112A (en) | 1978-05-26 | 1979-05-25 | PROCESS FOR PREPARING A PENICILLANIC ACID DERIVATIVE CONTAINING PREPARATION WITH AN ANTI-BACTERIAL ACTION, PROCESS FOR PREPARING THE ACTIVE DERIVATIVE AND THE PHARMACEUTICAL AGENT SO OBTAINED. |
DE2921324A DE2921324C2 (en) | 1978-05-26 | 1979-05-25 | α-Benzoylureido-α-benzylpenicillins and their salts |
ES488131A ES488131A0 (en) | 1978-05-26 | 1980-01-31 | A PROCEDURE FOR THE PREPARATION OF A DERIVATIVE OF THE ACI-DO PENICILANICO |
ES488132A ES8101600A1 (en) | 1978-05-26 | 1980-01-31 | A procedure for the preparation of a penicilanic acid derivative. (Machine-translation by Google Translate, not legally binding) |
ES488130A ES8101598A1 (en) | 1978-05-26 | 1980-01-31 | A procedure for the preparation of a penicilanic acid derivative. (Machine-translation by Google Translate, not legally binding) |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10436278A JPS5531044A (en) | 1978-08-29 | 1978-08-29 | Penicillanic acid derivative and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5531044A true JPS5531044A (en) | 1980-03-05 |
Family
ID=14378710
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10436278A Pending JPS5531044A (en) | 1978-05-26 | 1978-08-29 | Penicillanic acid derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5531044A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58135891A (en) * | 1982-02-05 | 1983-08-12 | Chugai Pharmaceut Co Ltd | Penicillin derivative |
JP2008505125A (en) * | 2004-07-02 | 2008-02-21 | ザ ウォルター アンド エリザ ホール インスティチュート オブ メディカル リサーチ | Alpha helix mimic |
-
1978
- 1978-08-29 JP JP10436278A patent/JPS5531044A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58135891A (en) * | 1982-02-05 | 1983-08-12 | Chugai Pharmaceut Co Ltd | Penicillin derivative |
JP2008505125A (en) * | 2004-07-02 | 2008-02-21 | ザ ウォルター アンド エリザ ホール インスティチュート オブ メディカル リサーチ | Alpha helix mimic |
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