JPS5531044A - Penicillanic acid derivative and its preparation - Google Patents

Penicillanic acid derivative and its preparation

Info

Publication number
JPS5531044A
JPS5531044A JP10436278A JP10436278A JPS5531044A JP S5531044 A JPS5531044 A JP S5531044A JP 10436278 A JP10436278 A JP 10436278A JP 10436278 A JP10436278 A JP 10436278A JP S5531044 A JPS5531044 A JP S5531044A
Authority
JP
Japan
Prior art keywords
acid
derivative
penicillanic acid
reacting
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10436278A
Other languages
Japanese (ja)
Inventor
Nobuhiro Oi
Bunya Aoki
Teizo Shinozaki
Kanji Moro
Isao Matsunaga
Takao Nofuji
Toshiyuki Nehashi
Yusuke Harada
Hisao Endo
Takao Kimura
Hiroshi Okazaki
Haruki Ogawa
Minoru Shindo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Priority to JP10436278A priority Critical patent/JPS5531044A/en
Priority to US06/005,832 priority patent/US4229348A/en
Priority to CA320,106A priority patent/CA1133896A/en
Priority to DD79210631A priority patent/DD143259A5/en
Priority to HU79CU160A priority patent/HU176076B/en
Priority to DK179579A priority patent/DK179579A/en
Priority to GB7916058A priority patent/GB2021576B/en
Priority to AU46898/79A priority patent/AU4689879A/en
Priority to IL57264A priority patent/IL57264A0/en
Priority to NO791687A priority patent/NO791687L/en
Priority to IT68103/79A priority patent/IT1120970B/en
Priority to ES480906A priority patent/ES480906A1/en
Priority to PT69665A priority patent/PT69665A/en
Priority to FI791680A priority patent/FI791680A/en
Priority to FR7913332A priority patent/FR2426691A1/en
Priority to NL7904112BA priority patent/NL7904112A/en
Priority to DE2921324A priority patent/DE2921324C2/en
Priority to ES488131A priority patent/ES488131A0/en
Priority to ES488132A priority patent/ES8101600A1/en
Priority to ES488130A priority patent/ES8101598A1/en
Publication of JPS5531044A publication Critical patent/JPS5531044A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:A penicillanic acid derivative of formula I (R1 is H, lower alkoxy, lower alkoxycarbonyl, halogen; R2 is H, OH; n is 1W3), or its salt.
EXAMPLE: 6-{α-[ 3-( 2-Hydroxybenzoyl )-1-ureido ]-α-phenylacetamido} penicillanic acid.
USE: An antibacterial agent stable under neutral and acidic conditions, having strong bactericidal activity and low toxicity, and effective to prevent the infection with bacteria.
PROCESS: The compound I is prepared, e.g. by reacting a substituted ureidophenylacetic acid or its reactive derivative with 6-aminopenicillanic acid or its reactive derivative in a solvent such as acetone, etc. The compound II is novel, and prepared, e.g. by reacting the corresponding α-aminophenylacetic acid with the corresponding OH-protected benzoyl isocyanate derivative.
COPYRIGHT: (C)1980,JPO&Japio
JP10436278A 1978-05-26 1978-08-29 Penicillanic acid derivative and its preparation Pending JPS5531044A (en)

Priority Applications (20)

Application Number Priority Date Filing Date Title
JP10436278A JPS5531044A (en) 1978-08-29 1978-08-29 Penicillanic acid derivative and its preparation
US06/005,832 US4229348A (en) 1978-05-26 1979-01-23 Penicillanic acid derivatives
CA320,106A CA1133896A (en) 1978-05-26 1979-01-23 Penicillanic acid derivative and process for preparing the same
DD79210631A DD143259A5 (en) 1978-05-26 1979-01-25 PROCESS FOR THE PREPARATION OF PENICILLANSAEUREDERIVATES
HU79CU160A HU176076B (en) 1978-05-26 1979-01-26 Process for producing 2,2-dimethyl-6-aquare bracket-2-bracket-3-benzoyl-1-ureido-bracket closed-2-phenyl-acetamido-square bracket closed-pename-3-carboxylic acid derivatives
DK179579A DK179579A (en) 1978-05-26 1979-05-01 PENICILLANIC ACID DERIVATIVES PROCEDURE FOR THEIR PREPARATION AND THEIR USE
GB7916058A GB2021576B (en) 1978-05-26 1979-05-09 Penicillins
AU46898/79A AU4689879A (en) 1978-05-26 1979-05-09 Penicillanic acid derivative
IL57264A IL57264A0 (en) 1978-05-26 1979-05-14 Penicillanic acid derivatives and process for preparing the same
NO791687A NO791687L (en) 1978-05-26 1979-05-22 PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE PENICILLANIC ACID DERIVATIVES
IT68103/79A IT1120970B (en) 1978-05-26 1979-05-24 PENICILLANIC ACID DERIVATIVE AND PROCEDURE FOR ITS PREPARATION
ES480906A ES480906A1 (en) 1978-05-26 1979-05-24 Procedure for the preparation of a penicilanic acid derivative. (Machine-translation by Google Translate, not legally binding)
PT69665A PT69665A (en) 1978-05-26 1979-05-24 PENICILANIC ACID DERIVATIVE AND PROCESS FOR PREPARING THE SAME
FI791680A FI791680A (en) 1978-05-26 1979-05-25 PENICILLANSYRADERIVAT OCH FOERFARANDE FOER FRAMSTAELLNING AV DET
FR7913332A FR2426691A1 (en) 1978-05-26 1979-05-25 PENICILLANIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
NL7904112BA NL7904112A (en) 1978-05-26 1979-05-25 PROCESS FOR PREPARING A PENICILLANIC ACID DERIVATIVE CONTAINING PREPARATION WITH AN ANTI-BACTERIAL ACTION, PROCESS FOR PREPARING THE ACTIVE DERIVATIVE AND THE PHARMACEUTICAL AGENT SO OBTAINED.
DE2921324A DE2921324C2 (en) 1978-05-26 1979-05-25 α-Benzoylureido-α-benzylpenicillins and their salts
ES488131A ES488131A0 (en) 1978-05-26 1980-01-31 A PROCEDURE FOR THE PREPARATION OF A DERIVATIVE OF THE ACI-DO PENICILANICO
ES488132A ES8101600A1 (en) 1978-05-26 1980-01-31 A procedure for the preparation of a penicilanic acid derivative. (Machine-translation by Google Translate, not legally binding)
ES488130A ES8101598A1 (en) 1978-05-26 1980-01-31 A procedure for the preparation of a penicilanic acid derivative. (Machine-translation by Google Translate, not legally binding)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10436278A JPS5531044A (en) 1978-08-29 1978-08-29 Penicillanic acid derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS5531044A true JPS5531044A (en) 1980-03-05

Family

ID=14378710

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10436278A Pending JPS5531044A (en) 1978-05-26 1978-08-29 Penicillanic acid derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5531044A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58135891A (en) * 1982-02-05 1983-08-12 Chugai Pharmaceut Co Ltd Penicillin derivative
JP2008505125A (en) * 2004-07-02 2008-02-21 ザ ウォルター アンド エリザ ホール インスティチュート オブ メディカル リサーチ Alpha helix mimic

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58135891A (en) * 1982-02-05 1983-08-12 Chugai Pharmaceut Co Ltd Penicillin derivative
JP2008505125A (en) * 2004-07-02 2008-02-21 ザ ウォルター アンド エリザ ホール インスティチュート オブ メディカル リサーチ Alpha helix mimic

Similar Documents

Publication Publication Date Title
JPS5531044A (en) Penicillanic acid derivative and its preparation
JPS5524135A (en) Penicillin derivative and its preparation
JPS5746988A (en) Novel penicillin derivative and its preparation
JPS5643288A (en) Cephalosporin derivative and its preparation
JPS5466695A (en) Azetidinone derivative and its preparation
JPS55147284A (en) Novel beta-lactam derivative and its preparation
JPS5777670A (en) Preparation of 2-azetidinone derivative
JPS5446836A (en) Antibacterial composition
JPS5616489A (en) Imidazolecarboxylic acid derivative
JPS57159777A (en) 4-hydroxycyclopentenone compound and its preparation
JPS5610165A (en) Novel beta-lactam compound and its production
JPS5640687A (en) Preparation of penicillanic acid derivative or its salt
JPS5515454A (en) Novel cephalosporin derivative
JPS54154782A (en) Penicillin derivative and its salt
JPS5673087A (en) Cephalosporin derivative, its preparation and antimicrobial agent consisting of the same
JPS5718687A (en) Penicillin derivative and its salt
JPS56108794A (en) Preparation of 7-amino-3-thiadiazolylthiomethyl-3-cephem- 4-carboxylic acid derivative
JPS54106486A (en) Alpha-acyloxybenzoyl ureido-benzylpenicillin
JPS54135767A (en) Penicillanic acid derivative
JPS5598188A (en) Novel cephalosporin and its preparation
JPS57106682A (en) Novel penicillins and their preparation
JPS5549384A (en) Novel antibacterial compound
JPS5665893A (en) Novel penicillin, and antibiotic agent containing said compound as effective component
JPS5448784A (en) N,n-dimethylacetamide adduct of cephalosporin and its preparation
JPS57108091A (en) Novel carbapenem type antibiotic and its preparation