JPS54106486A - Alpha-acyloxybenzoyl ureido-benzylpenicillin - Google Patents

Alpha-acyloxybenzoyl ureido-benzylpenicillin

Info

Publication number
JPS54106486A
JPS54106486A JP518578A JP518578A JPS54106486A JP S54106486 A JPS54106486 A JP S54106486A JP 518578 A JP518578 A JP 518578A JP 518578 A JP518578 A JP 518578A JP S54106486 A JPS54106486 A JP S54106486A
Authority
JP
Japan
Prior art keywords
benzylpenicillin
salt
formula
acyloxybenzoyl
ureido
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP518578A
Other languages
Japanese (ja)
Inventor
Nobuhiro Oi
Bunya Aoki
Teizo Shinozaki
Kanji Moro
Isao Matsunaga
Takao Nofuji
Toshiyuki Nehashi
Yusuke Harada
Hisao Endo
Hiroshi Okazaki
Haruki Ogawa
Minoru Shindo
Takao Kimura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Priority to JP518578A priority Critical patent/JPS54106486A/en
Publication of JPS54106486A publication Critical patent/JPS54106486A/en
Pending legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:An α-(acyloxybenzoylureido) benzylpenicillin of the formula (R is lower alkyl group) and its salt.
USE: Artibacterials, which have improved activity against bacteria of the genus Pseudomonas, compared with carbenicillin, improved protection against infection, powerful bactericidal activity and low toxicity, are relatively stable under acidic conditions, and widely used.
PROCESS: An α-aminobenzyl penicillin, e.g. ampicillin, or its functional derivative, e.g. an ester or salt at the 3-carboxyl group, is reacted with a 0-lower alkanoyloxybenzoyl isocyanate in a solvent, e.g. acetone or THF, under cooling or at room temperature to give the objective compound of formula.
COPYRIGHT: (C)1979,JPO&Japio
JP518578A 1978-01-23 1978-01-23 Alpha-acyloxybenzoyl ureido-benzylpenicillin Pending JPS54106486A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP518578A JPS54106486A (en) 1978-01-23 1978-01-23 Alpha-acyloxybenzoyl ureido-benzylpenicillin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP518578A JPS54106486A (en) 1978-01-23 1978-01-23 Alpha-acyloxybenzoyl ureido-benzylpenicillin

Publications (1)

Publication Number Publication Date
JPS54106486A true JPS54106486A (en) 1979-08-21

Family

ID=11604161

Family Applications (1)

Application Number Title Priority Date Filing Date
JP518578A Pending JPS54106486A (en) 1978-01-23 1978-01-23 Alpha-acyloxybenzoyl ureido-benzylpenicillin

Country Status (1)

Country Link
JP (1) JPS54106486A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008505125A (en) * 2004-07-02 2008-02-21 ザ ウォルター アンド エリザ ホール インスティチュート オブ メディカル リサーチ Alpha helix mimic

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008505125A (en) * 2004-07-02 2008-02-21 ザ ウォルター アンド エリザ ホール インスティチュート オブ メディカル リサーチ Alpha helix mimic

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