JPS54106486A - Alpha-acyloxybenzoyl ureido-benzylpenicillin - Google Patents
Alpha-acyloxybenzoyl ureido-benzylpenicillinInfo
- Publication number
- JPS54106486A JPS54106486A JP518578A JP518578A JPS54106486A JP S54106486 A JPS54106486 A JP S54106486A JP 518578 A JP518578 A JP 518578A JP 518578 A JP518578 A JP 518578A JP S54106486 A JPS54106486 A JP S54106486A
- Authority
- JP
- Japan
- Prior art keywords
- benzylpenicillin
- salt
- formula
- acyloxybenzoyl
- ureido
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:An α-(acyloxybenzoylureido) benzylpenicillin of the formula (R is lower alkyl group) and its salt.
USE: Artibacterials, which have improved activity against bacteria of the genus Pseudomonas, compared with carbenicillin, improved protection against infection, powerful bactericidal activity and low toxicity, are relatively stable under acidic conditions, and widely used.
PROCESS: An α-aminobenzyl penicillin, e.g. ampicillin, or its functional derivative, e.g. an ester or salt at the 3-carboxyl group, is reacted with a 0-lower alkanoyloxybenzoyl isocyanate in a solvent, e.g. acetone or THF, under cooling or at room temperature to give the objective compound of formula.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP518578A JPS54106486A (en) | 1978-01-23 | 1978-01-23 | Alpha-acyloxybenzoyl ureido-benzylpenicillin |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP518578A JPS54106486A (en) | 1978-01-23 | 1978-01-23 | Alpha-acyloxybenzoyl ureido-benzylpenicillin |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS54106486A true JPS54106486A (en) | 1979-08-21 |
Family
ID=11604161
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP518578A Pending JPS54106486A (en) | 1978-01-23 | 1978-01-23 | Alpha-acyloxybenzoyl ureido-benzylpenicillin |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54106486A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008505125A (en) * | 2004-07-02 | 2008-02-21 | ザ ウォルター アンド エリザ ホール インスティチュート オブ メディカル リサーチ | Alpha helix mimic |
-
1978
- 1978-01-23 JP JP518578A patent/JPS54106486A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008505125A (en) * | 2004-07-02 | 2008-02-21 | ザ ウォルター アンド エリザ ホール インスティチュート オブ メディカル リサーチ | Alpha helix mimic |
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