JPS5446800A - Antibacterial compound - Google Patents

Antibacterial compound

Info

Publication number
JPS5446800A
JPS5446800A JP11402277A JP11402277A JPS5446800A JP S5446800 A JPS5446800 A JP S5446800A JP 11402277 A JP11402277 A JP 11402277A JP 11402277 A JP11402277 A JP 11402277A JP S5446800 A JPS5446800 A JP S5446800A
Authority
JP
Japan
Prior art keywords
acid
phenylacetamide
dioxo
ethyl
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP11402277A
Other languages
Japanese (ja)
Inventor
Hisayasu Ishimaru
Mariko Hatamura
Takeshi Nitta
Minoru Hatanaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SANGYO KAGAKU KENKYU KYOKAI
Original Assignee
SANGYO KAGAKU KENKYU KYOKAI
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SANGYO KAGAKU KENKYU KYOKAI filed Critical SANGYO KAGAKU KENKYU KYOKAI
Priority to JP11402277A priority Critical patent/JPS5446800A/en
Publication of JPS5446800A publication Critical patent/JPS5446800A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:D-(-)-6-substituted acylamindepenicillanic acid of formulaI(R1 is lower alkyl; R2 is H, halogne; R3 is lower alkyl; n is 1, 2) or its salt.
EXAMPLE: 6-[D-(-)-α-(4-ethyl-2,3-dioxo-1-piperazinocarbonylamino)-p-(ethoxycarbonyloxy)phenylacetamide]penicillanic acid and its sodium salt.
USE: Antibiotic. It has double the effectiveness of known 6-[D-(-)α-(4-ethyl-2,3- dioxo-1-piperazincbonylamino-phenylacetamide]penicillanic acid that has a wide range of antibacyerial spectra containing Pseudomonas aeruginosa.
PREPARATION: A reactive derivative of a carboxylic acid of formula II is reacted with 6-APA and the product is acylated with a halocarbonate ester to afford a compound of formula I.
COPYRIGHT: (C)1979,JPO&Japio
JP11402277A 1977-09-22 1977-09-22 Antibacterial compound Pending JPS5446800A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP11402277A JPS5446800A (en) 1977-09-22 1977-09-22 Antibacterial compound

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11402277A JPS5446800A (en) 1977-09-22 1977-09-22 Antibacterial compound

Publications (1)

Publication Number Publication Date
JPS5446800A true JPS5446800A (en) 1979-04-12

Family

ID=14627074

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11402277A Pending JPS5446800A (en) 1977-09-22 1977-09-22 Antibacterial compound

Country Status (1)

Country Link
JP (1) JPS5446800A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018048197A (en) * 2009-06-10 2018-03-29 テックフィールズ ファーマ カンパニー リミテッド High penetration compositions or prodrugs of antimicrobials and antimicrobial-related compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018048197A (en) * 2009-06-10 2018-03-29 テックフィールズ ファーマ カンパニー リミテッド High penetration compositions or prodrugs of antimicrobials and antimicrobial-related compounds

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