JPS5446800A - Antibacterial compound - Google Patents
Antibacterial compoundInfo
- Publication number
- JPS5446800A JPS5446800A JP11402277A JP11402277A JPS5446800A JP S5446800 A JPS5446800 A JP S5446800A JP 11402277 A JP11402277 A JP 11402277A JP 11402277 A JP11402277 A JP 11402277A JP S5446800 A JPS5446800 A JP S5446800A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- phenylacetamide
- dioxo
- ethyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:D-(-)-6-substituted acylamindepenicillanic acid of formulaI(R1 is lower alkyl; R2 is H, halogne; R3 is lower alkyl; n is 1, 2) or its salt.
EXAMPLE: 6-[D-(-)-α-(4-ethyl-2,3-dioxo-1-piperazinocarbonylamino)-p-(ethoxycarbonyloxy)phenylacetamide]penicillanic acid and its sodium salt.
USE: Antibiotic. It has double the effectiveness of known 6-[D-(-)α-(4-ethyl-2,3- dioxo-1-piperazincbonylamino-phenylacetamide]penicillanic acid that has a wide range of antibacyerial spectra containing Pseudomonas aeruginosa.
PREPARATION: A reactive derivative of a carboxylic acid of formula II is reacted with 6-APA and the product is acylated with a halocarbonate ester to afford a compound of formula I.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11402277A JPS5446800A (en) | 1977-09-22 | 1977-09-22 | Antibacterial compound |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11402277A JPS5446800A (en) | 1977-09-22 | 1977-09-22 | Antibacterial compound |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5446800A true JPS5446800A (en) | 1979-04-12 |
Family
ID=14627074
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP11402277A Pending JPS5446800A (en) | 1977-09-22 | 1977-09-22 | Antibacterial compound |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5446800A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2018048197A (en) * | 2009-06-10 | 2018-03-29 | テックフィールズ ファーマ カンパニー リミテッド | High penetration compositions or prodrugs of antimicrobials and antimicrobial-related compounds |
-
1977
- 1977-09-22 JP JP11402277A patent/JPS5446800A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2018048197A (en) * | 2009-06-10 | 2018-03-29 | テックフィールズ ファーマ カンパニー リミテッド | High penetration compositions or prodrugs of antimicrobials and antimicrobial-related compounds |
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