JPS5569592A - Penicillanic acid derivative - Google Patents

Penicillanic acid derivative

Info

Publication number
JPS5569592A
JPS5569592A JP14178578A JP14178578A JPS5569592A JP S5569592 A JPS5569592 A JP S5569592A JP 14178578 A JP14178578 A JP 14178578A JP 14178578 A JP14178578 A JP 14178578A JP S5569592 A JPS5569592 A JP S5569592A
Authority
JP
Japan
Prior art keywords
formula
compound
acid derivative
oxo
penicillanic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP14178578A
Other languages
Japanese (ja)
Other versions
JPS6037119B2 (en
Inventor
Hiroshi Ishikawa
Fujio Tafusa
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP53141785A priority Critical patent/JPS6037119B2/en
Priority to DE2953974A priority patent/DE2953974C2/de
Priority to DE19792914258 priority patent/DE2914258A1/en
Priority to DE2953973A priority patent/DE2953973C2/de
Priority to DE2914218A priority patent/DE2914218C2/en
Priority to DK149479A priority patent/DK149479A/en
Priority to NO79791223A priority patent/NO791223L/en
Priority to US06/028,770 priority patent/US4317820A/en
Priority to IT48690/79A priority patent/IT1196531B/en
Priority to IT48691/79A priority patent/IT1162605B/en
Priority to AR276166A priority patent/AR227005A1/en
Priority to CH343379A priority patent/CH640853A5/en
Priority to FI791190A priority patent/FI70219C/en
Priority to CA325,375A priority patent/CA1133469A/en
Priority to SU792753360A priority patent/SU1151212A3/en
Priority to CA000325376A priority patent/CA1153374A/en
Priority to ES480281A priority patent/ES480281A1/en
Priority to CH343479A priority patent/CH642081A5/en
Priority to PT69473A priority patent/PT69473A/en
Priority to MX797868U priority patent/MX5704E/en
Priority to AU46037/79A priority patent/AU529330B2/en
Priority to AT0269079A priority patent/AT368159B/en
Priority to AU46038/79A priority patent/AU524795B2/en
Priority to NLAANVRAGE7902906,A priority patent/NL180589C/en
Priority to GB7913039A priority patent/GB2019844B/en
Priority to FR7909338A priority patent/FR2422658A1/en
Priority to FR7909337A priority patent/FR2422666A1/en
Priority to SE7903297A priority patent/SE7903297L/en
Priority to NLAANVRAGE7902905,A priority patent/NL180664C/en
Priority to GB7913040A priority patent/GB2020279B/en
Priority to SE7903298A priority patent/SE436280B/en
Priority to PH22472A priority patent/PH16154A/en
Priority to ES488833A priority patent/ES488833A0/en
Publication of JPS5569592A publication Critical patent/JPS5569592A/en
Priority to US06/195,691 priority patent/US4416884A/en
Priority to AT95881A priority patent/AT371121B/en
Priority to AR284582A priority patent/AR226883A1/en
Priority to NO84840617A priority patent/NO840617L/en
Publication of JPS6037119B2 publication Critical patent/JPS6037119B2/en
Expired legal-status Critical Current

Links

Abstract

NEW MATERIAL:A penicillanic acid derivative of formula 1: (R1 is lower alkyl group; R2 is H or OH), and its salt.
EXAMPLE: 6-[2-(5-Methyl-6, 7-dihydro-1-oxo-1H, 5H-benzo[ ij ]quinolidine-2-carboxamido)-2-phenylacetamido]-3, 3-dimethyl-7-oxo-4-thia-1-azabicyclo[3,2,0]heptane-2-carboxylic acid.
USE: Antibacterials effective against Gram-negative and Gram-positive bacteria, particularly Pseudomonas aeruginosa and hemolytic streptococci.
PROCESS: A compound of formula 2 is subjected to the Schotten-Baumann reaction with a compound of formula 3: (R3 is lower alkyl group; M is H or alkali metal) to give a carboxyl group-active compound of formula 4, which is, without isolation, reacted with an amplicillin of formula 5 to form the compound of formula 1.
COPYRIGHT: (C)1980,JPO&Japio
JP53141785A 1978-04-12 1978-11-16 penicillanic acid derivatives Expired JPS6037119B2 (en)

Priority Applications (37)

Application Number Priority Date Filing Date Title
JP53141785A JPS6037119B2 (en) 1978-11-16 1978-11-16 penicillanic acid derivatives
DE2953974A DE2953974C2 (en) 1978-04-12 1979-04-09
DE19792914258 DE2914258A1 (en) 1978-04-12 1979-04-09 PIPERAZINYLBENZOHETEROCYCLIC COMPOUNDS, METHODS OF PREPARING THEREOF, AND AGENTS CONTAINING THEM
DE2953973A DE2953973C2 (en) 1978-04-12 1979-04-09
DE2914218A DE2914218C2 (en) 1978-04-12 1979-04-09 N-acyl derivatives of ampicillin and amoxicillin, processes for their preparation and pharmaceutical preparations which contain the compounds
DK149479A DK149479A (en) 1978-04-12 1979-04-10 PROCEDURE FOR THE PREPARATION OF BETALACTAM COMPOUNDS OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF
NO79791223A NO791223L (en) 1978-04-12 1979-04-10 PROCEDURE FOR THE PREPARATION OF BETA-LACTAM COMPOUNDS
US06/028,770 US4317820A (en) 1978-04-12 1979-04-10 β-Lactam series compound and antibacterial pharmaceutical composition containing the same
IT48690/79A IT1196531B (en) 1978-04-12 1979-04-10 PIPERAZINYL-BENZOETEROCYCLIC COMPOUNDS PROCEDURE FOR THE PRODUCTION AND PHARMACEUTICAL PREPARATION CONTAINING THEM
IT48691/79A IT1162605B (en) 1978-04-12 1979-04-10 COMPOUNDS OF THE BETA-LACTAMIC SERIES PROCEDURE TO PRODUCE THEM AND PHARMACEUTICAL PREPARATION THAT INCLUDES THEM
MX797868U MX5704E (en) 1978-04-12 1979-04-11 PROCEDURE FOR THE PREPARATION OF PENICILANIC ACID DERIVATIVES
CH343379A CH640853A5 (en) 1978-04-12 1979-04-11 Piperazinylbenzoheterozyklische compounds and preparation bacteriostatic what this includes.
FI791190A FI70219C (en) 1978-04-12 1979-04-11 PROCEDURE FOR THE FRAMSTATION OF BETA-LACTAMANT BIOOTICS
CA325,375A CA1133469A (en) 1978-04-12 1979-04-11 .beta.-LACTAM SERIES COMPOUND
SU792753360A SU1151212A3 (en) 1978-04-12 1979-04-11 Method of obtaining penicillin derivatives or their pharmaceutically acceptable salts (versions)
CA000325376A CA1153374A (en) 1978-04-12 1979-04-11 Piperazinylbenzoheterocyclic compounds
ES480281A ES480281A1 (en) 1978-04-12 1979-04-11 beta -Lactam series compound and antibacterial pharmaceutical composition containing the same
CH343479A CH642081A5 (en) 1978-04-12 1979-04-11 DERIVATIVES OF THE BETA LACTAM SERIES AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM.
PT69473A PT69473A (en) 1978-04-12 1979-04-11 Process for preparing beta-lactam series compounds
AR276166A AR227005A1 (en) 1978-04-12 1979-04-11 A METHOD FOR PREPARING AN OXO- (PIRIDO 3,2,1-JK-CARBAZOL OR BENZO (IJ) -QUINOLIZINA OR PIRROLO 3,2,1-IJ-QUINOLINA) -CARBOXAMIDO-2-FENILACETAMIDO-OXO-TIA-1- AZABICICLO- (HEPTANO OR OCT-2-ENE) -2-CARBOXILICO ACID
AU46037/79A AU529330B2 (en) 1978-04-12 1979-04-11 Piperazinylbenzoheterocyclic compounds
AT0269079A AT368159B (en) 1978-04-12 1979-04-11 METHOD FOR PRODUCING NEW BETA LACTAM COMPOUNDS
AU46038/79A AU524795B2 (en) 1978-04-12 1979-04-11 Beta-lactam series compound
FR7909338A FR2422658A1 (en) 1978-04-12 1979-04-12 PIPERAZINYL-BENZOHETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND THEIR THERAPEUTIC USES
GB7913039A GB2019844B (en) 1978-04-12 1979-04-12 Lactam series compound
NLAANVRAGE7902906,A NL180589C (en) 1978-04-12 1979-04-12 COMPOUNDS WITH ANTI-MICROBIAL ACTION FROM THE BETA-LACTAM SERIES AND PHARMACEUTICAL PREPARATIONS CONTAINING SUCH A COMPOUND AS AN ACTIVE SUBSTANCE.
FR7909337A FR2422666A1 (en) 1978-04-12 1979-04-12 NEW B-LACTAM-TYPE COMPOUNDS USEFUL AS ANTIMICROBIAL AGENTS AND THEIR PREPARATION PROCESS
SE7903297A SE7903297L (en) 1978-04-12 1979-04-12 BETA-LAKTAM ASSOCIATIONS
NLAANVRAGE7902905,A NL180664C (en) 1978-04-12 1979-04-12 1,8-ALKYLENE-3-CARBOXY-4-OXO-7-PIPERAZINOQUINOLINE DERIVATIVES, METHOD FOR THE PREPARATION THEREOF, AND ANTI-MICROBILE PREPARATIONS CONTAINING SUCH A COMPOUND AS AN ACTIVE SUBSTANCE.
GB7913040A GB2020279B (en) 1978-04-12 1979-04-12 Piperazinylbenzoheterocyclic compounds
SE7903298A SE436280B (en) 1978-04-12 1979-04-12 Piperazinylbenzoheterocyclic compounds and anti-microbial preparations thereof
PH22472A PH16154A (en) 1978-09-07 1979-05-10 Beta-lactam series compound and antibacterial pharmaceutical composition containing the same
ES488833A ES488833A0 (en) 1978-04-12 1980-01-30 METHOD OF PREPARING COMPOUNDS FROM THE BETA-LACTA-MAS AND SIMILAR SERIES
US06/195,691 US4416884A (en) 1978-04-12 1980-10-09 Piperazinylbenzoheterocyclic compounds
AT95881A AT371121B (en) 1978-04-12 1981-03-02 METHOD FOR PRODUCING NEW BETA LACTAMEN COMPOUNDS
AR284582A AR226883A1 (en) 1978-04-12 1981-03-11 METHOD FOR PREPARING AN OXO- (PIRIDO (3,2,1-JK) CARBAZOL OR BENZO (IJ) QUINOLIZINA OR PIRROLO (3,2,1-IJ) QUINOLINA) -CARBOXAMIDO-2-FENILACETAMIDO-OXO-TIA-1- AZABICICLO- (HEPTANO OR OCT-2-ENE) -2-CARBOXILICO ACID
NO84840617A NO840617L (en) 1978-04-12 1984-02-20 ANALOGICAL PROCEDURE FOR THE PREPARATION OF PHARMACOLOGICALLY ACTIVE CEPHALOSPORINE DERIVATIVES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP53141785A JPS6037119B2 (en) 1978-11-16 1978-11-16 penicillanic acid derivatives

Publications (2)

Publication Number Publication Date
JPS5569592A true JPS5569592A (en) 1980-05-26
JPS6037119B2 JPS6037119B2 (en) 1985-08-24

Family

ID=15300098

Family Applications (1)

Application Number Title Priority Date Filing Date
JP53141785A Expired JPS6037119B2 (en) 1978-04-12 1978-11-16 penicillanic acid derivatives

Country Status (1)

Country Link
JP (1) JPS6037119B2 (en)

Also Published As

Publication number Publication date
JPS6037119B2 (en) 1985-08-24

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