JPS5732290A - Novel penicillin derivative and its preparation - Google Patents

Novel penicillin derivative and its preparation

Info

Publication number
JPS5732290A
JPS5732290A JP10858180A JP10858180A JPS5732290A JP S5732290 A JPS5732290 A JP S5732290A JP 10858180 A JP10858180 A JP 10858180A JP 10858180 A JP10858180 A JP 10858180A JP S5732290 A JPS5732290 A JP S5732290A
Authority
JP
Japan
Prior art keywords
formula
preparation
acid
penicillin derivative
solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10858180A
Other languages
Japanese (ja)
Inventor
Dotaro Fujimoto
Giichi Funatsukuri
Toshimitsu Shigeari
Takeshi Sakai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujimoto Pharmaceutical Corp
Original Assignee
Fujimoto Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujimoto Pharmaceutical Corp filed Critical Fujimoto Pharmaceutical Corp
Priority to JP10858180A priority Critical patent/JPS5732290A/en
Publication of JPS5732290A publication Critical patent/JPS5732290A/en
Pending legal-status Critical Current

Links

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

NEW MATERIAL:6-[ D-(-)-α-( 1-Ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxamido )-phenylacetamido ]-penicillanic acid of formula I.
USE: Antibacterial agent effective to Gram-negative bacteria, especially to bacteria belonging to Pseudomonas genus.
PROCESS: Ampicillin of formula II is made to react with the reactive derivative of nalidixic acid of formula III in a mixed solvent of e.g. methylene chloride, isopropyl alcohol, and triethylamine. The solvent is distilled off, the residual solid is dissolved in an aqueous solution of sodium bicarbonate, and the objective compound is crystallized by acidifying the solution with phosphoric acid.
COPYRIGHT: (C)1982,JPO&Japio
JP10858180A 1980-08-06 1980-08-06 Novel penicillin derivative and its preparation Pending JPS5732290A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10858180A JPS5732290A (en) 1980-08-06 1980-08-06 Novel penicillin derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10858180A JPS5732290A (en) 1980-08-06 1980-08-06 Novel penicillin derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS5732290A true JPS5732290A (en) 1982-02-20

Family

ID=14488436

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10858180A Pending JPS5732290A (en) 1980-08-06 1980-08-06 Novel penicillin derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5732290A (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5180719A (en) * 1988-10-24 1993-01-19 Norwich Eaton Pharmaceuticals, Inc. Antimicrobial quinolonyl lactam esters
US5328908A (en) * 1988-10-24 1994-07-12 Procter & Gamble Pharmaceuticals, Inc. Antimicrobial quinolone thioureas
US5387748A (en) * 1988-10-24 1995-02-07 Procter & Gamble Pharmaceuticals, Inc. Antimicrobial dithiocarbamoyl quinolones
US5434147A (en) * 1988-10-24 1995-07-18 Proctor & Gamble Pharmaceuticals, Inc. Antimicrobial quinolonyl lactam esters
US5491139A (en) * 1988-10-24 1996-02-13 The Procter & Gamble Company Antimicrobial quinolonyl lactams
US5530116A (en) * 1990-04-18 1996-06-25 The Procter & Gamble Company Antimicrobial quinolonyl lactams
US5637580A (en) * 1988-10-24 1997-06-10 The Procter & Gamble Company Antimicrobial penem-quinolones

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5180719A (en) * 1988-10-24 1993-01-19 Norwich Eaton Pharmaceuticals, Inc. Antimicrobial quinolonyl lactam esters
US5328908A (en) * 1988-10-24 1994-07-12 Procter & Gamble Pharmaceuticals, Inc. Antimicrobial quinolone thioureas
US5387748A (en) * 1988-10-24 1995-02-07 Procter & Gamble Pharmaceuticals, Inc. Antimicrobial dithiocarbamoyl quinolones
US5434147A (en) * 1988-10-24 1995-07-18 Proctor & Gamble Pharmaceuticals, Inc. Antimicrobial quinolonyl lactam esters
US5491139A (en) * 1988-10-24 1996-02-13 The Procter & Gamble Company Antimicrobial quinolonyl lactams
US5631256A (en) * 1988-10-24 1997-05-20 The Procter & Gamble Company Antimicrobial quinolone thioureas
US5637580A (en) * 1988-10-24 1997-06-10 The Procter & Gamble Company Antimicrobial penem-quinolones
US5646139A (en) * 1988-10-24 1997-07-08 The Procter & Gamble Company Antimicrobial carbapenem quinolones
US5648346A (en) * 1988-10-24 1997-07-15 The Procter & Gamble Company Antimicrobial carbacephem-quinolones
US5656623A (en) * 1988-10-24 1997-08-12 The Procter & Gamble Company Antimicrobial lactam-quinolones
US5672600A (en) * 1988-10-24 1997-09-30 The Procter & Gamble Company Antimicrobial dithiocarbamoyl quinolones
US5530116A (en) * 1990-04-18 1996-06-25 The Procter & Gamble Company Antimicrobial quinolonyl lactams

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