JPS5732290A - Novel penicillin derivative and its preparation - Google Patents
Novel penicillin derivative and its preparationInfo
- Publication number
- JPS5732290A JPS5732290A JP10858180A JP10858180A JPS5732290A JP S5732290 A JPS5732290 A JP S5732290A JP 10858180 A JP10858180 A JP 10858180A JP 10858180 A JP10858180 A JP 10858180A JP S5732290 A JPS5732290 A JP S5732290A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- preparation
- acid
- penicillin derivative
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
NEW MATERIAL:6-[ D-(-)-α-( 1-Ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxamido )-phenylacetamido ]-penicillanic acid of formula I.
USE: Antibacterial agent effective to Gram-negative bacteria, especially to bacteria belonging to Pseudomonas genus.
PROCESS: Ampicillin of formula II is made to react with the reactive derivative of nalidixic acid of formula III in a mixed solvent of e.g. methylene chloride, isopropyl alcohol, and triethylamine. The solvent is distilled off, the residual solid is dissolved in an aqueous solution of sodium bicarbonate, and the objective compound is crystallized by acidifying the solution with phosphoric acid.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10858180A JPS5732290A (en) | 1980-08-06 | 1980-08-06 | Novel penicillin derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10858180A JPS5732290A (en) | 1980-08-06 | 1980-08-06 | Novel penicillin derivative and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5732290A true JPS5732290A (en) | 1982-02-20 |
Family
ID=14488436
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10858180A Pending JPS5732290A (en) | 1980-08-06 | 1980-08-06 | Novel penicillin derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5732290A (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5180719A (en) * | 1988-10-24 | 1993-01-19 | Norwich Eaton Pharmaceuticals, Inc. | Antimicrobial quinolonyl lactam esters |
US5328908A (en) * | 1988-10-24 | 1994-07-12 | Procter & Gamble Pharmaceuticals, Inc. | Antimicrobial quinolone thioureas |
US5387748A (en) * | 1988-10-24 | 1995-02-07 | Procter & Gamble Pharmaceuticals, Inc. | Antimicrobial dithiocarbamoyl quinolones |
US5434147A (en) * | 1988-10-24 | 1995-07-18 | Proctor & Gamble Pharmaceuticals, Inc. | Antimicrobial quinolonyl lactam esters |
US5491139A (en) * | 1988-10-24 | 1996-02-13 | The Procter & Gamble Company | Antimicrobial quinolonyl lactams |
US5530116A (en) * | 1990-04-18 | 1996-06-25 | The Procter & Gamble Company | Antimicrobial quinolonyl lactams |
US5637580A (en) * | 1988-10-24 | 1997-06-10 | The Procter & Gamble Company | Antimicrobial penem-quinolones |
-
1980
- 1980-08-06 JP JP10858180A patent/JPS5732290A/en active Pending
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5180719A (en) * | 1988-10-24 | 1993-01-19 | Norwich Eaton Pharmaceuticals, Inc. | Antimicrobial quinolonyl lactam esters |
US5328908A (en) * | 1988-10-24 | 1994-07-12 | Procter & Gamble Pharmaceuticals, Inc. | Antimicrobial quinolone thioureas |
US5387748A (en) * | 1988-10-24 | 1995-02-07 | Procter & Gamble Pharmaceuticals, Inc. | Antimicrobial dithiocarbamoyl quinolones |
US5434147A (en) * | 1988-10-24 | 1995-07-18 | Proctor & Gamble Pharmaceuticals, Inc. | Antimicrobial quinolonyl lactam esters |
US5491139A (en) * | 1988-10-24 | 1996-02-13 | The Procter & Gamble Company | Antimicrobial quinolonyl lactams |
US5631256A (en) * | 1988-10-24 | 1997-05-20 | The Procter & Gamble Company | Antimicrobial quinolone thioureas |
US5637580A (en) * | 1988-10-24 | 1997-06-10 | The Procter & Gamble Company | Antimicrobial penem-quinolones |
US5646139A (en) * | 1988-10-24 | 1997-07-08 | The Procter & Gamble Company | Antimicrobial carbapenem quinolones |
US5648346A (en) * | 1988-10-24 | 1997-07-15 | The Procter & Gamble Company | Antimicrobial carbacephem-quinolones |
US5656623A (en) * | 1988-10-24 | 1997-08-12 | The Procter & Gamble Company | Antimicrobial lactam-quinolones |
US5672600A (en) * | 1988-10-24 | 1997-09-30 | The Procter & Gamble Company | Antimicrobial dithiocarbamoyl quinolones |
US5530116A (en) * | 1990-04-18 | 1996-06-25 | The Procter & Gamble Company | Antimicrobial quinolonyl lactams |
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