JPS54103889A - Novel 7alpha-methoxycephalosporin - Google Patents

Novel 7alpha-methoxycephalosporin

Info

Publication number
JPS54103889A
JPS54103889A JP986978A JP986978A JPS54103889A JP S54103889 A JPS54103889 A JP S54103889A JP 986978 A JP986978 A JP 986978A JP 986978 A JP986978 A JP 986978A JP S54103889 A JPS54103889 A JP S54103889A
Authority
JP
Japan
Prior art keywords
formula
compound
furyl
group
methoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP986978A
Other languages
Japanese (ja)
Other versions
JPS625918B2 (en
Inventor
Isamu Saikawa
Shuntaro Takano
Hiroyuki Imaizumi
Isamu Takakura
Yuichi Ochiai
Takashi Yasuda
Hideo Taki
Masaru Tai
Hiroshi Kodama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyama Chemical Co Ltd
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Priority to JP986978A priority Critical patent/JPS54103889A/en
Priority to DE2831568A priority patent/DE2831568C2/en
Priority to DE2857696A priority patent/DE2857696C2/en
Priority to IL55174A priority patent/IL55174A/en
Priority to AU38151/78A priority patent/AU511994B2/en
Priority to PH21402A priority patent/PH16562A/en
Priority to GB7830442A priority patent/GB2009161B/en
Priority to FI782294A priority patent/FI71744C/en
Priority to NLAANVRAGE7807806,A priority patent/NL180511C/en
Priority to DK326778A priority patent/DK164169C/en
Priority to CH789878A priority patent/CH646976A5/en
Priority to SE7808066A priority patent/SE444682B/en
Priority to FR7821731A priority patent/FR2398071A1/en
Publication of JPS54103889A publication Critical patent/JPS54103889A/en
Priority to US06/117,784 priority patent/US4321265A/en
Priority to IL60160A priority patent/IL60160A0/en
Priority to NL8003317A priority patent/NL8003317A/en
Priority to FI801963A priority patent/FI70025C/en
Priority to SE8004979A priority patent/SE446188B/en
Priority to FR8020027A priority patent/FR2468612A1/en
Priority to US06/221,622 priority patent/US4395412A/en
Priority to CH4574/83A priority patent/CH647524A5/en
Priority to DK136584A priority patent/DK136584D0/en
Priority to NLAANVRAGE8601026,A priority patent/NL182221C/en
Publication of JPS625918B2 publication Critical patent/JPS625918B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A 7α-methoxy cephalosporin of formula I: [R1 is H, carboxyl- protecting group, or salt-forming cation; R2 is organic group bonded via O or S, R3 and R4 are H or lower alkyl groups; A is alkyl group; B is furyl or 1,4-cyclohexadienyl group).
EXAMPLE: 7β-[D-α(4-Ethyl-2,3-dioxo-1-piperazinecarboxamido)-α-(2-furyl)acetamido]-7α-methoxy-3-[5-(1-methyl-1,2,3,4-tetrazolyl)thiomethyl]-Δ3-cephem-4- carboxylic acid.
USE: Antibacterials effective against Gram-positive and Gram-negative bacteria, particularly Bacillus pyocyaneus.
PROCESS: A compound of formula II is reacted with a compound of the formula CH3OM' (M' is alkali metal salt) in the bresence of methanol at -120W-10°C, then with a halogenating agent to form the compound of formula I.
COPYRIGHT: (C)1979,JPO&Japio
JP986978A 1977-07-23 1978-02-02 Novel 7alpha-methoxycephalosporin Granted JPS54103889A (en)

Priority Applications (23)

Application Number Priority Date Filing Date Title
JP986978A JPS54103889A (en) 1978-02-02 1978-02-02 Novel 7alpha-methoxycephalosporin
DE2831568A DE2831568C2 (en) 1977-07-23 1978-07-18 7 α-Methoxycephalosporins and methods for making the same
DE2857696A DE2857696C2 (en) 1977-07-23 1978-07-18 Cephalosporins
IL55174A IL55174A (en) 1977-07-23 1978-07-19 7 beta(alpha-(2,3-dioxo-1-piperazine carboxamido)acetamido)-7alpha-methoxy-omega3-cephem-4-carboxylic acid derivatives,their preparation and pharmaceutical compositions comprising them
AU38151/78A AU511994B2 (en) 1977-07-23 1978-07-19 7a-Methoxycephalosporins
PH21402A PH16562A (en) 1977-07-23 1978-07-19 Novel alpha-methoxycephalosporins and pharmaceutical composition
GB7830442A GB2009161B (en) 1977-07-23 1978-07-20 7a-methocacephalosproins and process for producing the sams
FI782294A FI71744C (en) 1977-07-23 1978-07-20 Process for the preparation of novel therapeutically useful 7-methoxy cephalosporin derivatives.
CH789878A CH646976A5 (en) 1977-07-23 1978-07-21 7-ALPHA-METHOXYCEPHALOSPORINE AND METHOD FOR PRODUCING THE SAME.
FR7821731A FR2398071A1 (en) 1977-07-23 1978-07-21 NEWS 7 A-METHOXYCEPHALOSPORINS, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
DK326778A DK164169C (en) 1977-07-23 1978-07-21 METHOD OF ANALOGUE FOR THE PREPARATION OF 7-ALFA METHOXYCEPHALOSPORINES OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF AND AN INTERMEDIATE USE FOR USE THEREOF
NLAANVRAGE7807806,A NL180511C (en) 1977-07-23 1978-07-21 PHARMACEUTICAL PREPARATION WITH ANTIBACTERIAL EFFECT, AND 7BETA- (2- (4-ALKYL-2,3-DIOXOPIPERAZINE-1-YLCARBONYLAMINO) ACETYLAMINO) -3- (SUBSTITUTED METHYL) -3-CEPHUMIC-4-CARPHEM-4-CARBONYL.
SE7808066A SE444682B (en) 1977-07-23 1978-07-21 NEW 7ALFA METOXICE PHALOSPORINES
US06/117,784 US4321265A (en) 1977-07-23 1980-02-01 7α-Methoxycephalosporins
IL60160A IL60160A0 (en) 1977-07-23 1980-05-26 Novel cephalosporins and process for producing the same
NL8003317A NL8003317A (en) 1977-07-23 1980-06-06 NEW CEPHALOSPORINES AND METHOD FOR PREPARING THE SAME
FI801963A FI70025C (en) 1977-07-23 1980-06-18 FRAME FOR THE PREPARATION OF THERAPEUTIC ANALYTICAL PRODUCTS 7-2,3-DIOXO-1-PIPERAZINYLKARBOXAMIDO / CEFALOSPORINDERIVAT
SE8004979A SE446188B (en) 1977-07-23 1980-07-04 7- / 2,3-dioxo-1-PIPERZINKARBOXAMIDO / -CEFALOSPORINDERIVAT
FR8020027A FR2468612A1 (en) 1977-07-23 1980-09-17 NEW CEPHALOSPORINS AND PROCESS FOR THEIR PREPARATION
US06/221,622 US4395412A (en) 1977-07-23 1980-12-31 7α-Methoxycephalosporins
CH4574/83A CH647524A5 (en) 1977-07-23 1983-08-22 7ALPHA-METHOXYCEPHALOSPORINE AND METHOD FOR THE PRODUCTION THEREOF.
DK136584A DK136584D0 (en) 1977-07-23 1984-02-29 ANALOGY PROCEDURE FOR THE PRODUCTION OF CEPHALOSPORINES OR SALTS THEREOF
NLAANVRAGE8601026,A NL182221C (en) 1977-07-23 1986-04-22 PHARMACEUTICAL PREPARATION WITH ANTIBACTERIAL EFFECT, AND 7BETA- (2- (4-ALKYL-2,3-DIOXOPIPERAZINE-1-YLCARBONYLAMINO) ACETYLAMINO) -3- (SUBSTITUTED METHYL) -3-CEPHUMIC-4-CARPHEM-4-CARBONYL.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP986978A JPS54103889A (en) 1978-02-02 1978-02-02 Novel 7alpha-methoxycephalosporin

Publications (2)

Publication Number Publication Date
JPS54103889A true JPS54103889A (en) 1979-08-15
JPS625918B2 JPS625918B2 (en) 1987-02-07

Family

ID=11732137

Family Applications (1)

Application Number Title Priority Date Filing Date
JP986978A Granted JPS54103889A (en) 1977-07-23 1978-02-02 Novel 7alpha-methoxycephalosporin

Country Status (1)

Country Link
JP (1) JPS54103889A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS557202A (en) * 1978-06-13 1980-01-19 Toyama Chem Co Ltd New 7alpha-methoxycephalosporins

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS557202A (en) * 1978-06-13 1980-01-19 Toyama Chem Co Ltd New 7alpha-methoxycephalosporins
JPS6027679B2 (en) * 1978-06-13 1985-06-29 富山化学工業株式会社 Novel 7α-methoxycephalosporins, their salts and their production method

Also Published As

Publication number Publication date
JPS625918B2 (en) 1987-02-07

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