JPS5524135A - Penicillin derivative and its preparation - Google Patents
Penicillin derivative and its preparationInfo
- Publication number
- JPS5524135A JPS5524135A JP9730978A JP9730978A JPS5524135A JP S5524135 A JPS5524135 A JP S5524135A JP 9730978 A JP9730978 A JP 9730978A JP 9730978 A JP9730978 A JP 9730978A JP S5524135 A JPS5524135 A JP S5524135A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- compound
- derivative
- prepared
- reactive derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A penicillin derivative or its salt of formula I (R1 is lower alkyl, R2 is H, lower alkoxy, lower alkoxycarbonyl, halogen; R3 is H, OH; n is 1W3; m is 1Wn; ρm denotes the position of substitution group, i.e. 3W5 positions in phenyl group).
EXAMPLE: 6-{D-(-)-α-[3-(3,4-dihydroxybenzoyl)-3-methyl-1-ureido]-α-(4-hydroxyphenyl)-acetamido} penicillanic acid.
USE: Antibacterial agent stable under neutral or acidic coinditions, having strong actibacterial activity, and low toxicity, and effective to prevent infection with bacteria.
PROCESS: The compound I is prepared by reacting a substituted ureidophenylacetic acid II or its reactive derivative with 6-aminopenicillanic acid or its reactive derivative. The compound II is a novel compound prepared, e.g. from the corresponding α-aminophenylacetic acid, etc.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (22)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9730978A JPS5524135A (en) | 1978-08-11 | 1978-08-11 | Penicillin derivative and its preparation |
CA320,106A CA1133896A (en) | 1978-05-26 | 1979-01-23 | Penicillanic acid derivative and process for preparing the same |
US06/005,832 US4229348A (en) | 1978-05-26 | 1979-01-23 | Penicillanic acid derivatives |
DD79210631A DD143259A5 (en) | 1978-05-26 | 1979-01-25 | PROCESS FOR THE PREPARATION OF PENICILLANSAEUREDERIVATES |
DD79222851A DD152130A5 (en) | 1978-05-26 | 1979-01-25 | PROCESS FOR THE PREPARATION OF PENICILLANSAEUREDERIVATES |
HU79CU160A HU176076B (en) | 1978-05-26 | 1979-01-26 | Process for producing 2,2-dimethyl-6-aquare bracket-2-bracket-3-benzoyl-1-ureido-bracket closed-2-phenyl-acetamido-square bracket closed-pename-3-carboxylic acid derivatives |
DK179579A DK179579A (en) | 1978-05-26 | 1979-05-01 | PENICILLANIC ACID DERIVATIVES PROCEDURE FOR THEIR PREPARATION AND THEIR USE |
AU46898/79A AU4689879A (en) | 1978-05-26 | 1979-05-09 | Penicillanic acid derivative |
GB7916058A GB2021576B (en) | 1978-05-26 | 1979-05-09 | Penicillins |
IL57264A IL57264A0 (en) | 1978-05-26 | 1979-05-14 | Penicillanic acid derivatives and process for preparing the same |
NO791687A NO791687L (en) | 1978-05-26 | 1979-05-22 | PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE PENICILLANIC ACID DERIVATIVES |
ES480906A ES480906A1 (en) | 1978-05-26 | 1979-05-24 | Procedure for the preparation of a penicilanic acid derivative. (Machine-translation by Google Translate, not legally binding) |
IT68103/79A IT1120970B (en) | 1978-05-26 | 1979-05-24 | PENICILLANIC ACID DERIVATIVE AND PROCEDURE FOR ITS PREPARATION |
PT69665A PT69665A (en) | 1978-05-26 | 1979-05-24 | PENICILANIC ACID DERIVATIVE AND PROCESS FOR PREPARING THE SAME |
DE2921324A DE2921324C2 (en) | 1978-05-26 | 1979-05-25 | α-Benzoylureido-α-benzylpenicillins and their salts |
SE7904575A SE7904575L (en) | 1978-05-26 | 1979-05-25 | PENICILLANIC ACID DERIVATIVES AND PROCEDURES FOR THE PREPARATION THEREOF |
NL7904112BA NL7904112A (en) | 1978-05-26 | 1979-05-25 | PROCESS FOR PREPARING A PENICILLANIC ACID DERIVATIVE CONTAINING PREPARATION WITH AN ANTI-BACTERIAL ACTION, PROCESS FOR PREPARING THE ACTIVE DERIVATIVE AND THE PHARMACEUTICAL AGENT SO OBTAINED. |
FI791680A FI791680A (en) | 1978-05-26 | 1979-05-25 | PENICILLANSYRADERIVAT OCH FOERFARANDE FOER FRAMSTAELLNING AV DET |
FR7913332A FR2426691A1 (en) | 1978-05-26 | 1979-05-25 | PENICILLANIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
ES488130A ES488130A0 (en) | 1978-05-26 | 1980-01-31 | A PROCEDURE FOR THE PREPARATION OF A DERIVATIVE OF THE ACI-DO PENICILANICO |
ES488131A ES8101599A1 (en) | 1978-05-26 | 1980-01-31 | A procedure for the preparation of a penicilanic acid derivative. (Machine-translation by Google Translate, not legally binding) |
ES488132A ES8101600A1 (en) | 1978-05-26 | 1980-01-31 | A procedure for the preparation of a penicilanic acid derivative. (Machine-translation by Google Translate, not legally binding) |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9730978A JPS5524135A (en) | 1978-08-11 | 1978-08-11 | Penicillin derivative and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5524135A true JPS5524135A (en) | 1980-02-21 |
Family
ID=14188878
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9730978A Pending JPS5524135A (en) | 1978-05-26 | 1978-08-11 | Penicillin derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5524135A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5732289A (en) * | 1980-08-05 | 1982-02-20 | Chugai Pharmaceut Co Ltd | Alpha-substituted ureidobenzylpenicillin |
JPS5810585A (en) * | 1981-07-10 | 1983-01-21 | Chugai Pharmaceut Co Ltd | Alpha-substituted ureidobenzylpenicillanic acid |
JPS58135891A (en) * | 1982-02-05 | 1983-08-12 | Chugai Pharmaceut Co Ltd | Penicillin derivative |
JP2006521311A (en) * | 2003-03-26 | 2006-09-21 | バイエル クロップサイエンス ゲーエムベーハー | Use of aromatic hydroxy compounds as safeners |
-
1978
- 1978-08-11 JP JP9730978A patent/JPS5524135A/en active Pending
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5732289A (en) * | 1980-08-05 | 1982-02-20 | Chugai Pharmaceut Co Ltd | Alpha-substituted ureidobenzylpenicillin |
JPH0118916B2 (en) * | 1980-08-05 | 1989-04-07 | Chugai Pharmaceutical Co Ltd | |
JPS5810585A (en) * | 1981-07-10 | 1983-01-21 | Chugai Pharmaceut Co Ltd | Alpha-substituted ureidobenzylpenicillanic acid |
JPS58135891A (en) * | 1982-02-05 | 1983-08-12 | Chugai Pharmaceut Co Ltd | Penicillin derivative |
JP2006521311A (en) * | 2003-03-26 | 2006-09-21 | バイエル クロップサイエンス ゲーエムベーハー | Use of aromatic hydroxy compounds as safeners |
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