JPS5524135A - Penicillin derivative and its preparation - Google Patents

Penicillin derivative and its preparation

Info

Publication number
JPS5524135A
JPS5524135A JP9730978A JP9730978A JPS5524135A JP S5524135 A JPS5524135 A JP S5524135A JP 9730978 A JP9730978 A JP 9730978A JP 9730978 A JP9730978 A JP 9730978A JP S5524135 A JPS5524135 A JP S5524135A
Authority
JP
Japan
Prior art keywords
acid
compound
derivative
prepared
reactive derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9730978A
Other languages
Japanese (ja)
Inventor
Nobuhiro Oi
Bunya Aoki
Teizo Shinozaki
Kanji Moro
Isao Matsunaga
Takao Nofuji
Toshiyuki Nehashi
Yusuke Harada
Hisao Endo
Takao Kimura
Hiroshi Okazaki
Haruki Ogawa
Minoru Shindo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Priority to JP9730978A priority Critical patent/JPS5524135A/en
Priority to CA320,106A priority patent/CA1133896A/en
Priority to US06/005,832 priority patent/US4229348A/en
Priority to DD79210631A priority patent/DD143259A5/en
Priority to DD79222851A priority patent/DD152130A5/en
Priority to HU79CU160A priority patent/HU176076B/en
Priority to DK179579A priority patent/DK179579A/en
Priority to AU46898/79A priority patent/AU4689879A/en
Priority to GB7916058A priority patent/GB2021576B/en
Priority to IL57264A priority patent/IL57264A0/en
Priority to NO791687A priority patent/NO791687L/en
Priority to ES480906A priority patent/ES480906A1/en
Priority to IT68103/79A priority patent/IT1120970B/en
Priority to PT69665A priority patent/PT69665A/en
Priority to DE2921324A priority patent/DE2921324C2/en
Priority to SE7904575A priority patent/SE7904575L/en
Priority to NL7904112BA priority patent/NL7904112A/en
Priority to FI791680A priority patent/FI791680A/en
Priority to FR7913332A priority patent/FR2426691A1/en
Priority to ES488130A priority patent/ES488130A0/en
Priority to ES488131A priority patent/ES8101599A1/en
Priority to ES488132A priority patent/ES8101600A1/en
Publication of JPS5524135A publication Critical patent/JPS5524135A/en
Pending legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A penicillin derivative or its salt of formula I (R1 is lower alkyl, R2 is H, lower alkoxy, lower alkoxycarbonyl, halogen; R3 is H, OH; n is 1W3; m is 1Wn; ρm denotes the position of substitution group, i.e. 3W5 positions in phenyl group).
EXAMPLE: 6-{D-(-)-α-[3-(3,4-dihydroxybenzoyl)-3-methyl-1-ureido]-α-(4-hydroxyphenyl)-acetamido} penicillanic acid.
USE: Antibacterial agent stable under neutral or acidic coinditions, having strong actibacterial activity, and low toxicity, and effective to prevent infection with bacteria.
PROCESS: The compound I is prepared by reacting a substituted ureidophenylacetic acid II or its reactive derivative with 6-aminopenicillanic acid or its reactive derivative. The compound II is a novel compound prepared, e.g. from the corresponding α-aminophenylacetic acid, etc.
COPYRIGHT: (C)1980,JPO&Japio
JP9730978A 1978-05-26 1978-08-11 Penicillin derivative and its preparation Pending JPS5524135A (en)

Priority Applications (22)

Application Number Priority Date Filing Date Title
JP9730978A JPS5524135A (en) 1978-08-11 1978-08-11 Penicillin derivative and its preparation
CA320,106A CA1133896A (en) 1978-05-26 1979-01-23 Penicillanic acid derivative and process for preparing the same
US06/005,832 US4229348A (en) 1978-05-26 1979-01-23 Penicillanic acid derivatives
DD79210631A DD143259A5 (en) 1978-05-26 1979-01-25 PROCESS FOR THE PREPARATION OF PENICILLANSAEUREDERIVATES
DD79222851A DD152130A5 (en) 1978-05-26 1979-01-25 PROCESS FOR THE PREPARATION OF PENICILLANSAEUREDERIVATES
HU79CU160A HU176076B (en) 1978-05-26 1979-01-26 Process for producing 2,2-dimethyl-6-aquare bracket-2-bracket-3-benzoyl-1-ureido-bracket closed-2-phenyl-acetamido-square bracket closed-pename-3-carboxylic acid derivatives
DK179579A DK179579A (en) 1978-05-26 1979-05-01 PENICILLANIC ACID DERIVATIVES PROCEDURE FOR THEIR PREPARATION AND THEIR USE
AU46898/79A AU4689879A (en) 1978-05-26 1979-05-09 Penicillanic acid derivative
GB7916058A GB2021576B (en) 1978-05-26 1979-05-09 Penicillins
IL57264A IL57264A0 (en) 1978-05-26 1979-05-14 Penicillanic acid derivatives and process for preparing the same
NO791687A NO791687L (en) 1978-05-26 1979-05-22 PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE PENICILLANIC ACID DERIVATIVES
ES480906A ES480906A1 (en) 1978-05-26 1979-05-24 Procedure for the preparation of a penicilanic acid derivative. (Machine-translation by Google Translate, not legally binding)
IT68103/79A IT1120970B (en) 1978-05-26 1979-05-24 PENICILLANIC ACID DERIVATIVE AND PROCEDURE FOR ITS PREPARATION
PT69665A PT69665A (en) 1978-05-26 1979-05-24 PENICILANIC ACID DERIVATIVE AND PROCESS FOR PREPARING THE SAME
DE2921324A DE2921324C2 (en) 1978-05-26 1979-05-25 α-Benzoylureido-α-benzylpenicillins and their salts
SE7904575A SE7904575L (en) 1978-05-26 1979-05-25 PENICILLANIC ACID DERIVATIVES AND PROCEDURES FOR THE PREPARATION THEREOF
NL7904112BA NL7904112A (en) 1978-05-26 1979-05-25 PROCESS FOR PREPARING A PENICILLANIC ACID DERIVATIVE CONTAINING PREPARATION WITH AN ANTI-BACTERIAL ACTION, PROCESS FOR PREPARING THE ACTIVE DERIVATIVE AND THE PHARMACEUTICAL AGENT SO OBTAINED.
FI791680A FI791680A (en) 1978-05-26 1979-05-25 PENICILLANSYRADERIVAT OCH FOERFARANDE FOER FRAMSTAELLNING AV DET
FR7913332A FR2426691A1 (en) 1978-05-26 1979-05-25 PENICILLANIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
ES488130A ES488130A0 (en) 1978-05-26 1980-01-31 A PROCEDURE FOR THE PREPARATION OF A DERIVATIVE OF THE ACI-DO PENICILANICO
ES488131A ES8101599A1 (en) 1978-05-26 1980-01-31 A procedure for the preparation of a penicilanic acid derivative. (Machine-translation by Google Translate, not legally binding)
ES488132A ES8101600A1 (en) 1978-05-26 1980-01-31 A procedure for the preparation of a penicilanic acid derivative. (Machine-translation by Google Translate, not legally binding)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9730978A JPS5524135A (en) 1978-08-11 1978-08-11 Penicillin derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS5524135A true JPS5524135A (en) 1980-02-21

Family

ID=14188878

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9730978A Pending JPS5524135A (en) 1978-05-26 1978-08-11 Penicillin derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5524135A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5732289A (en) * 1980-08-05 1982-02-20 Chugai Pharmaceut Co Ltd Alpha-substituted ureidobenzylpenicillin
JPS5810585A (en) * 1981-07-10 1983-01-21 Chugai Pharmaceut Co Ltd Alpha-substituted ureidobenzylpenicillanic acid
JPS58135891A (en) * 1982-02-05 1983-08-12 Chugai Pharmaceut Co Ltd Penicillin derivative
JP2006521311A (en) * 2003-03-26 2006-09-21 バイエル クロップサイエンス ゲーエムベーハー Use of aromatic hydroxy compounds as safeners

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5732289A (en) * 1980-08-05 1982-02-20 Chugai Pharmaceut Co Ltd Alpha-substituted ureidobenzylpenicillin
JPH0118916B2 (en) * 1980-08-05 1989-04-07 Chugai Pharmaceutical Co Ltd
JPS5810585A (en) * 1981-07-10 1983-01-21 Chugai Pharmaceut Co Ltd Alpha-substituted ureidobenzylpenicillanic acid
JPS58135891A (en) * 1982-02-05 1983-08-12 Chugai Pharmaceut Co Ltd Penicillin derivative
JP2006521311A (en) * 2003-03-26 2006-09-21 バイエル クロップサイエンス ゲーエムベーハー Use of aromatic hydroxy compounds as safeners

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