JPS5576875A - Benzo ij quinolizine-2-carboxylic acid derivative and its preparation - Google Patents

Benzo ij quinolizine-2-carboxylic acid derivative and its preparation

Info

Publication number
JPS5576875A
JPS5576875A JP10738778A JP10738778A JPS5576875A JP S5576875 A JPS5576875 A JP S5576875A JP 10738778 A JP10738778 A JP 10738778A JP 10738778 A JP10738778 A JP 10738778A JP S5576875 A JPS5576875 A JP S5576875A
Authority
JP
Japan
Prior art keywords
compound
formula
halogen
quinolizine
benzo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10738778A
Other languages
Japanese (ja)
Other versions
JPS622598B2 (en
Inventor
Hiroshi Ishikawa
Fujio Tafusa
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP10738778A priority Critical patent/JPS5576875A/en
Priority to DE2953973A priority patent/DE2953973C2/de
Priority to DE19792914258 priority patent/DE2914258A1/en
Priority to DE2953974A priority patent/DE2953974C2/de
Priority to IT48690/79A priority patent/IT1196531B/en
Priority to NO791224A priority patent/NO152788C/en
Priority to ZA791714A priority patent/ZA791714B/en
Priority to DK149379A priority patent/DK160306C/en
Priority to ES480274A priority patent/ES480274A1/en
Priority to CA000325376A priority patent/CA1153374A/en
Priority to MX786779U priority patent/MX6158E/en
Priority to SU792751555A priority patent/SU993818A3/en
Priority to PT6947479A priority patent/PT69474A/en
Priority to AU46037/79A priority patent/AU529330B2/en
Priority to FI791191A priority patent/FI66612C/en
Priority to CH343379A priority patent/CH640853A5/en
Priority to AT269179A priority patent/AT376673B/en
Priority to NLAANVRAGE7902905,A priority patent/NL180664C/en
Priority to GB7913040A priority patent/GB2020279B/en
Priority to FR7909338A priority patent/FR2422658A1/en
Priority to GB7913039A priority patent/GB2019844B/en
Priority to SE7903298A priority patent/SE436280B/en
Publication of JPS5576875A publication Critical patent/JPS5576875A/en
Priority to US06/195,691 priority patent/US4416884A/en
Priority to SU823375813A priority patent/SU1407399A3/en
Priority to AT290183A priority patent/AT377986B/en
Publication of JPS622598B2 publication Critical patent/JPS622598B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

NEW MATERIAL:A compound of formula I: (R<1> is H or lower alkyl group; R<2> is H, lower alkyl, lower alkanoyl, benzoyl group, etc.; R<3> is H or halogen), and its salt. EXAMPLE:8-( 1-Piperazinyl )-6,7-dihydro-1-oxo-1H,5H-benzo[ ij ]quinolizine-2-carboxylic acid. USE:Antibacterials effective against Gram-positive and Gram-negative bacteria, particularly Pseudomonas aeruginosa and hemolytic streptococci. PROCESS:A compound of formula II: (R<4> is halogen, lower alkanesulfonyloxy group, etc.) is reacted with a compound of formula III to give the objective compound of formula I. The compound of formula II: (R<4> is not halogen) is novel, and obtained by cyclizing and hydrolyzing the reaction product of a compound of formula V: (R<6> is lower alkyl) with an intermediate, prepared from a compound of formula IV and a compound of the formula R<5>X (R<5> is lower alkanesulfonyl, etc.; X is halogen).
JP10738778A 1978-04-12 1978-08-31 Benzo ij quinolizine-2-carboxylic acid derivative and its preparation Granted JPS5576875A (en)

Priority Applications (25)

Application Number Priority Date Filing Date Title
JP10738778A JPS5576875A (en) 1978-08-31 1978-08-31 Benzo ij quinolizine-2-carboxylic acid derivative and its preparation
DE2953973A DE2953973C2 (en) 1978-04-12 1979-04-09
DE19792914258 DE2914258A1 (en) 1978-04-12 1979-04-09 PIPERAZINYLBENZOHETEROCYCLIC COMPOUNDS, METHODS OF PREPARING THEREOF, AND AGENTS CONTAINING THEM
DE2953974A DE2953974C2 (en) 1978-04-12 1979-04-09
IT48690/79A IT1196531B (en) 1978-04-12 1979-04-10 PIPERAZINYL-BENZOETEROCYCLIC COMPOUNDS PROCEDURE FOR THE PRODUCTION AND PHARMACEUTICAL PREPARATION CONTAINING THEM
NO791224A NO152788C (en) 1978-08-31 1979-04-10 ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE PIPERAZINYLBENZOHETEROCYCLIC COMPOUNDS.
ZA791714A ZA791714B (en) 1978-08-31 1979-04-10 Piperazinylbenzoheterocyclic compounds
DK149379A DK160306C (en) 1978-08-31 1979-04-10 METHOD OF ANALOGUE FOR THE PREPARATION OF PIPERAZINYLBENZOHETEROCYCLIC COMPOUNDS OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF
AU46037/79A AU529330B2 (en) 1978-04-12 1979-04-11 Piperazinylbenzoheterocyclic compounds
CA000325376A CA1153374A (en) 1978-04-12 1979-04-11 Piperazinylbenzoheterocyclic compounds
MX786779U MX6158E (en) 1978-08-31 1979-04-11 PROCEDURE FOR THE PREPARATION OF PIPERAZINYLBENZOHETEROCICLICOS DERIVATIVES
SU792751555A SU993818A3 (en) 1978-08-31 1979-04-11 Process for preparing derivatives of piperazinyl benzoheterocyclic compounds or their acid addition salts
PT6947479A PT69474A (en) 1978-08-31 1979-04-11 PROCESS FOR PREPARING PIPERAZINYLBENZOHETEROCYCLIC COMPOUNDS
ES480274A ES480274A1 (en) 1978-08-31 1979-04-11 Method of preparing piperacinilbenzoheterociclicos and intermediate compounds. (Machine-translation by Google Translate, not legally binding)
FI791191A FI66612C (en) 1978-08-31 1979-04-11 FAR OIL FRAMSTAELLNING AV NYA SAOSOM ANTIMICROBICA ANAENDBARA PIPERAZINYLBENSOHETEROCYCLISKA FOERENINGAR
CH343379A CH640853A5 (en) 1978-04-12 1979-04-11 Piperazinylbenzoheterozyklische compounds and preparation bacteriostatic what this includes.
AT269179A AT376673B (en) 1978-08-31 1979-04-11 METHOD FOR PRODUCING NEW PIPERAZINYLBENZOHETEROCYCLIC COMPOUNDS AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS
NLAANVRAGE7902905,A NL180664C (en) 1978-04-12 1979-04-12 1,8-ALKYLENE-3-CARBOXY-4-OXO-7-PIPERAZINOQUINOLINE DERIVATIVES, METHOD FOR THE PREPARATION THEREOF, AND ANTI-MICROBILE PREPARATIONS CONTAINING SUCH A COMPOUND AS AN ACTIVE SUBSTANCE.
GB7913040A GB2020279B (en) 1978-04-12 1979-04-12 Piperazinylbenzoheterocyclic compounds
FR7909338A FR2422658A1 (en) 1978-04-12 1979-04-12 PIPERAZINYL-BENZOHETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND THEIR THERAPEUTIC USES
GB7913039A GB2019844B (en) 1978-04-12 1979-04-12 Lactam series compound
SE7903298A SE436280B (en) 1978-04-12 1979-04-12 Piperazinylbenzoheterocyclic compounds and anti-microbial preparations thereof
US06/195,691 US4416884A (en) 1978-04-12 1980-10-09 Piperazinylbenzoheterocyclic compounds
SU823375813A SU1407399A3 (en) 1978-08-31 1982-01-18 Method of producing derivatives of piperazinylbenzoheterocyclic compounds of their pharmaceutically acceptable salts
AT290183A AT377986B (en) 1978-08-31 1983-08-11 METHOD FOR PRODUCING NEW PIPERAZINYLBENZOHETEROCYCLIC COMPOUNDS AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10738778A JPS5576875A (en) 1978-08-31 1978-08-31 Benzo ij quinolizine-2-carboxylic acid derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS5576875A true JPS5576875A (en) 1980-06-10
JPS622598B2 JPS622598B2 (en) 1987-01-20

Family

ID=14457832

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10738778A Granted JPS5576875A (en) 1978-04-12 1978-08-31 Benzo ij quinolizine-2-carboxylic acid derivative and its preparation

Country Status (3)

Country Link
JP (1) JPS5576875A (en)
SU (1) SU1407399A3 (en)
ZA (1) ZA791714B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55149284A (en) * 1980-05-02 1980-11-20 Otsuka Pharmaceut Co Ltd Piperazinylbenzo heterocyclic derivative
JPS5788183A (en) * 1980-11-21 1982-06-01 Dai Ichi Seiyaku Co Ltd Pyridobenzoxazine derivative
JPS63154621A (en) * 1986-12-18 1988-06-27 Dai Ichi Seiyaku Co Ltd Drug for external use

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63123592U (en) * 1987-02-04 1988-08-11

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55149284A (en) * 1980-05-02 1980-11-20 Otsuka Pharmaceut Co Ltd Piperazinylbenzo heterocyclic derivative
JPS6232194B2 (en) * 1980-05-02 1987-07-13 Otsuka Pharma Co Ltd
JPS5788183A (en) * 1980-11-21 1982-06-01 Dai Ichi Seiyaku Co Ltd Pyridobenzoxazine derivative
JPS63154621A (en) * 1986-12-18 1988-06-27 Dai Ichi Seiyaku Co Ltd Drug for external use

Also Published As

Publication number Publication date
ZA791714B (en) 1980-06-25
SU1407399A3 (en) 1988-06-30
JPS622598B2 (en) 1987-01-20

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