JPS55118485A - Benzo ij quinolizine-2-carboxylic acid derivative - Google Patents
Benzo ij quinolizine-2-carboxylic acid derivativeInfo
- Publication number
- JPS55118485A JPS55118485A JP13163279A JP13163279A JPS55118485A JP S55118485 A JPS55118485 A JP S55118485A JP 13163279 A JP13163279 A JP 13163279A JP 13163279 A JP13163279 A JP 13163279A JP S55118485 A JPS55118485 A JP S55118485A
- Authority
- JP
- Japan
- Prior art keywords
- benzo
- quinolizine
- carboxylic acid
- formula
- acid derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:A benzo[ij]quinolizine-2-carboxylic acid derivative of formula I (R1 is lower alkyl group, R2 is halogen; R3 is H, lower alkyl, or lower alkanoyl group) and its salt.
EXAMPLE: 8-(1-Piperazinyl)-9-chloro-5-methyl-6,7-dihydro-1-oxo-1H, 5H-benzo[ij] quinolizine-2-carboxylic acid.
USE: Antibacterials effective against Gram-positive and Gram-negative bacteria, particularly Pseudomonas aeruginosa and hemolytic streptococci, capable of increasing the activity by the combination with serum.
PROCESS: A benzo-hetero cyclic compound derivative of formula II (X1 is halogen) is reacted with a piperazine of formula III in an inert solvent, e.g. DMSO or DMF, at 100°CW250°C and 1W20atm to give the compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13163279A JPS55118485A (en) | 1979-10-11 | 1979-10-11 | Benzo ij quinolizine-2-carboxylic acid derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13163279A JPS55118485A (en) | 1979-10-11 | 1979-10-11 | Benzo ij quinolizine-2-carboxylic acid derivative |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2720479A Division JPS55118416A (en) | 1979-03-07 | 1979-03-07 | Antibacterial agent |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS55118485A true JPS55118485A (en) | 1980-09-11 |
Family
ID=15062580
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP13163279A Pending JPS55118485A (en) | 1979-10-11 | 1979-10-11 | Benzo ij quinolizine-2-carboxylic acid derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55118485A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57193459A (en) * | 1981-05-22 | 1982-11-27 | Otsuka Pharmaceut Co Ltd | Quinoline derivative |
-
1979
- 1979-10-11 JP JP13163279A patent/JPS55118485A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57193459A (en) * | 1981-05-22 | 1982-11-27 | Otsuka Pharmaceut Co Ltd | Quinoline derivative |
JPH0154344B2 (en) * | 1981-05-22 | 1989-11-17 | Otsuka Pharma Co Ltd |
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