JPS5564588A - Pyrrolo (3, 2, 1-ij) quinoline-5-carboxylic acid derivative and its preparation - Google Patents

Pyrrolo (3, 2, 1-ij) quinoline-5-carboxylic acid derivative and its preparation

Info

Publication number
JPS5564588A
JPS5564588A JP13715778A JP13715778A JPS5564588A JP S5564588 A JPS5564588 A JP S5564588A JP 13715778 A JP13715778 A JP 13715778A JP 13715778 A JP13715778 A JP 13715778A JP S5564588 A JPS5564588 A JP S5564588A
Authority
JP
Japan
Prior art keywords
pyrrolo
quinoline
carboxylic acid
formula
acid derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP13715778A
Other languages
Japanese (ja)
Inventor
Hiroshi Ishikawa
Fujio Tafusa
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP13715778A priority Critical patent/JPS5564588A/en
Priority to DE19792914258 priority patent/DE2914258A1/en
Priority to DE2953974A priority patent/DE2953974C2/de
Priority to DE2953973A priority patent/DE2953973C2/de
Priority to DK149379A priority patent/DK160306C/en
Priority to NO791224A priority patent/NO152788C/en
Priority to IT48690/79A priority patent/IT1196531B/en
Priority to MX786779U priority patent/MX6158E/en
Priority to CH343379A priority patent/CH640853A5/en
Priority to SU792751555A priority patent/SU993818A3/en
Priority to AT269179A priority patent/AT376673B/en
Priority to PT6947479A priority patent/PT69474A/en
Priority to AU46037/79A priority patent/AU529330B2/en
Priority to ES480274A priority patent/ES480274A1/en
Priority to FI791191A priority patent/FI66612C/en
Priority to CA000325376A priority patent/CA1153374A/en
Priority to SE7903298A priority patent/SE436280B/en
Priority to GB7913040A priority patent/GB2020279B/en
Priority to GB7913039A priority patent/GB2019844B/en
Priority to FR7909338A priority patent/FR2422658A1/en
Priority to NLAANVRAGE7902905,A priority patent/NL180664C/en
Publication of JPS5564588A publication Critical patent/JPS5564588A/en
Priority to US06/195,691 priority patent/US4416884A/en
Priority to AT290183A priority patent/AT377986B/en
Pending legal-status Critical Current

Links

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A pyrrolo [3, 2, 1-ij] quinoline-5-carboxylic acid derivative of formula I: (R is H, lower alkyl group) and its salt.
EXAMPLE: 9-( 1-Piperazinyl )-6-oxo-1, 2-dihydro-6H-pyrrolo [3, 2, 1-ij] quinoline-5- carboxylic acid.
USE: Antibacterials and their intermediates, effective against Gram-positive and Gram- negative bacteria, particularly pseudomonas aeruginosa and hemolytic streptococci, with low toxicity.
PROCESS: A compound of formula 2: (X is halogen) is reacted with piperazine of formula 3 in an inert solvent, e.g. DMSO, at 100W250°C, preferably 140W200°C, if necessary in the presence of a deacidification agent, to give the compound of formula 1.
COPYRIGHT: (C)1980,JPO&Japio
JP13715778A 1978-04-12 1978-11-06 Pyrrolo (3, 2, 1-ij) quinoline-5-carboxylic acid derivative and its preparation Pending JPS5564588A (en)

Priority Applications (23)

Application Number Priority Date Filing Date Title
JP13715778A JPS5564588A (en) 1978-11-06 1978-11-06 Pyrrolo (3, 2, 1-ij) quinoline-5-carboxylic acid derivative and its preparation
DE19792914258 DE2914258A1 (en) 1978-04-12 1979-04-09 PIPERAZINYLBENZOHETEROCYCLIC COMPOUNDS, METHODS OF PREPARING THEREOF, AND AGENTS CONTAINING THEM
DE2953974A DE2953974C2 (en) 1978-04-12 1979-04-09
DE2953973A DE2953973C2 (en) 1978-04-12 1979-04-09
DK149379A DK160306C (en) 1978-08-31 1979-04-10 METHOD OF ANALOGUE FOR THE PREPARATION OF PIPERAZINYLBENZOHETEROCYCLIC COMPOUNDS OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF
NO791224A NO152788C (en) 1978-08-31 1979-04-10 ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE PIPERAZINYLBENZOHETEROCYCLIC COMPOUNDS.
IT48690/79A IT1196531B (en) 1978-04-12 1979-04-10 PIPERAZINYL-BENZOETEROCYCLIC COMPOUNDS PROCEDURE FOR THE PRODUCTION AND PHARMACEUTICAL PREPARATION CONTAINING THEM
PT6947479A PT69474A (en) 1978-08-31 1979-04-11 PROCESS FOR PREPARING PIPERAZINYLBENZOHETEROCYCLIC COMPOUNDS
CH343379A CH640853A5 (en) 1978-04-12 1979-04-11 Piperazinylbenzoheterozyklische compounds and preparation bacteriostatic what this includes.
SU792751555A SU993818A3 (en) 1978-08-31 1979-04-11 Process for preparing derivatives of piperazinyl benzoheterocyclic compounds or their acid addition salts
AT269179A AT376673B (en) 1978-08-31 1979-04-11 METHOD FOR PRODUCING NEW PIPERAZINYLBENZOHETEROCYCLIC COMPOUNDS AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS
MX786779U MX6158E (en) 1978-08-31 1979-04-11 PROCEDURE FOR THE PREPARATION OF PIPERAZINYLBENZOHETEROCICLICOS DERIVATIVES
AU46037/79A AU529330B2 (en) 1978-04-12 1979-04-11 Piperazinylbenzoheterocyclic compounds
ES480274A ES480274A1 (en) 1978-08-31 1979-04-11 Method of preparing piperacinilbenzoheterociclicos and intermediate compounds. (Machine-translation by Google Translate, not legally binding)
FI791191A FI66612C (en) 1978-08-31 1979-04-11 FAR OIL FRAMSTAELLNING AV NYA SAOSOM ANTIMICROBICA ANAENDBARA PIPERAZINYLBENSOHETEROCYCLISKA FOERENINGAR
CA000325376A CA1153374A (en) 1978-04-12 1979-04-11 Piperazinylbenzoheterocyclic compounds
SE7903298A SE436280B (en) 1978-04-12 1979-04-12 Piperazinylbenzoheterocyclic compounds and anti-microbial preparations thereof
GB7913040A GB2020279B (en) 1978-04-12 1979-04-12 Piperazinylbenzoheterocyclic compounds
GB7913039A GB2019844B (en) 1978-04-12 1979-04-12 Lactam series compound
FR7909338A FR2422658A1 (en) 1978-04-12 1979-04-12 PIPERAZINYL-BENZOHETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND THEIR THERAPEUTIC USES
NLAANVRAGE7902905,A NL180664C (en) 1978-04-12 1979-04-12 1,8-ALKYLENE-3-CARBOXY-4-OXO-7-PIPERAZINOQUINOLINE DERIVATIVES, METHOD FOR THE PREPARATION THEREOF, AND ANTI-MICROBILE PREPARATIONS CONTAINING SUCH A COMPOUND AS AN ACTIVE SUBSTANCE.
US06/195,691 US4416884A (en) 1978-04-12 1980-10-09 Piperazinylbenzoheterocyclic compounds
AT290183A AT377986B (en) 1978-08-31 1983-08-11 METHOD FOR PRODUCING NEW PIPERAZINYLBENZOHETEROCYCLIC COMPOUNDS AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13715778A JPS5564588A (en) 1978-11-06 1978-11-06 Pyrrolo (3, 2, 1-ij) quinoline-5-carboxylic acid derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS5564588A true JPS5564588A (en) 1980-05-15

Family

ID=15192144

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13715778A Pending JPS5564588A (en) 1978-04-12 1978-11-06 Pyrrolo (3, 2, 1-ij) quinoline-5-carboxylic acid derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5564588A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100420663B1 (en) * 2001-01-09 2004-03-02 주식회사 켐온 Novel Quinoline derivatives, the process for the preparation thereof and pharmaceutical compositions containing them

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100420663B1 (en) * 2001-01-09 2004-03-02 주식회사 켐온 Novel Quinoline derivatives, the process for the preparation thereof and pharmaceutical compositions containing them

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