JPS5564588A - Pyrrolo (3, 2, 1-ij) quinoline-5-carboxylic acid derivative and its preparation - Google Patents
Pyrrolo (3, 2, 1-ij) quinoline-5-carboxylic acid derivative and its preparationInfo
- Publication number
- JPS5564588A JPS5564588A JP13715778A JP13715778A JPS5564588A JP S5564588 A JPS5564588 A JP S5564588A JP 13715778 A JP13715778 A JP 13715778A JP 13715778 A JP13715778 A JP 13715778A JP S5564588 A JPS5564588 A JP S5564588A
- Authority
- JP
- Japan
- Prior art keywords
- pyrrolo
- quinoline
- carboxylic acid
- formula
- acid derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A pyrrolo [3, 2, 1-ij] quinoline-5-carboxylic acid derivative of formula I: (R is H, lower alkyl group) and its salt.
EXAMPLE: 9-( 1-Piperazinyl )-6-oxo-1, 2-dihydro-6H-pyrrolo [3, 2, 1-ij] quinoline-5- carboxylic acid.
USE: Antibacterials and their intermediates, effective against Gram-positive and Gram- negative bacteria, particularly pseudomonas aeruginosa and hemolytic streptococci, with low toxicity.
PROCESS: A compound of formula 2: (X is halogen) is reacted with piperazine of formula 3 in an inert solvent, e.g. DMSO, at 100W250°C, preferably 140W200°C, if necessary in the presence of a deacidification agent, to give the compound of formula 1.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (23)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13715778A JPS5564588A (en) | 1978-11-06 | 1978-11-06 | Pyrrolo (3, 2, 1-ij) quinoline-5-carboxylic acid derivative and its preparation |
DE19792914258 DE2914258A1 (en) | 1978-04-12 | 1979-04-09 | PIPERAZINYLBENZOHETEROCYCLIC COMPOUNDS, METHODS OF PREPARING THEREOF, AND AGENTS CONTAINING THEM |
DE2953974A DE2953974C2 (en) | 1978-04-12 | 1979-04-09 | |
DE2953973A DE2953973C2 (en) | 1978-04-12 | 1979-04-09 | |
DK149379A DK160306C (en) | 1978-08-31 | 1979-04-10 | METHOD OF ANALOGUE FOR THE PREPARATION OF PIPERAZINYLBENZOHETEROCYCLIC COMPOUNDS OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF |
NO791224A NO152788C (en) | 1978-08-31 | 1979-04-10 | ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE PIPERAZINYLBENZOHETEROCYCLIC COMPOUNDS. |
IT48690/79A IT1196531B (en) | 1978-04-12 | 1979-04-10 | PIPERAZINYL-BENZOETEROCYCLIC COMPOUNDS PROCEDURE FOR THE PRODUCTION AND PHARMACEUTICAL PREPARATION CONTAINING THEM |
PT6947479A PT69474A (en) | 1978-08-31 | 1979-04-11 | PROCESS FOR PREPARING PIPERAZINYLBENZOHETEROCYCLIC COMPOUNDS |
CH343379A CH640853A5 (en) | 1978-04-12 | 1979-04-11 | Piperazinylbenzoheterozyklische compounds and preparation bacteriostatic what this includes. |
SU792751555A SU993818A3 (en) | 1978-08-31 | 1979-04-11 | Process for preparing derivatives of piperazinyl benzoheterocyclic compounds or their acid addition salts |
AT269179A AT376673B (en) | 1978-08-31 | 1979-04-11 | METHOD FOR PRODUCING NEW PIPERAZINYLBENZOHETEROCYCLIC COMPOUNDS AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS |
MX786779U MX6158E (en) | 1978-08-31 | 1979-04-11 | PROCEDURE FOR THE PREPARATION OF PIPERAZINYLBENZOHETEROCICLICOS DERIVATIVES |
AU46037/79A AU529330B2 (en) | 1978-04-12 | 1979-04-11 | Piperazinylbenzoheterocyclic compounds |
ES480274A ES480274A1 (en) | 1978-08-31 | 1979-04-11 | Method of preparing piperacinilbenzoheterociclicos and intermediate compounds. (Machine-translation by Google Translate, not legally binding) |
FI791191A FI66612C (en) | 1978-08-31 | 1979-04-11 | FAR OIL FRAMSTAELLNING AV NYA SAOSOM ANTIMICROBICA ANAENDBARA PIPERAZINYLBENSOHETEROCYCLISKA FOERENINGAR |
CA000325376A CA1153374A (en) | 1978-04-12 | 1979-04-11 | Piperazinylbenzoheterocyclic compounds |
SE7903298A SE436280B (en) | 1978-04-12 | 1979-04-12 | Piperazinylbenzoheterocyclic compounds and anti-microbial preparations thereof |
GB7913040A GB2020279B (en) | 1978-04-12 | 1979-04-12 | Piperazinylbenzoheterocyclic compounds |
GB7913039A GB2019844B (en) | 1978-04-12 | 1979-04-12 | Lactam series compound |
FR7909338A FR2422658A1 (en) | 1978-04-12 | 1979-04-12 | PIPERAZINYL-BENZOHETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND THEIR THERAPEUTIC USES |
NLAANVRAGE7902905,A NL180664C (en) | 1978-04-12 | 1979-04-12 | 1,8-ALKYLENE-3-CARBOXY-4-OXO-7-PIPERAZINOQUINOLINE DERIVATIVES, METHOD FOR THE PREPARATION THEREOF, AND ANTI-MICROBILE PREPARATIONS CONTAINING SUCH A COMPOUND AS AN ACTIVE SUBSTANCE. |
US06/195,691 US4416884A (en) | 1978-04-12 | 1980-10-09 | Piperazinylbenzoheterocyclic compounds |
AT290183A AT377986B (en) | 1978-08-31 | 1983-08-11 | METHOD FOR PRODUCING NEW PIPERAZINYLBENZOHETEROCYCLIC COMPOUNDS AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13715778A JPS5564588A (en) | 1978-11-06 | 1978-11-06 | Pyrrolo (3, 2, 1-ij) quinoline-5-carboxylic acid derivative and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5564588A true JPS5564588A (en) | 1980-05-15 |
Family
ID=15192144
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP13715778A Pending JPS5564588A (en) | 1978-04-12 | 1978-11-06 | Pyrrolo (3, 2, 1-ij) quinoline-5-carboxylic acid derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5564588A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100420663B1 (en) * | 2001-01-09 | 2004-03-02 | 주식회사 켐온 | Novel Quinoline derivatives, the process for the preparation thereof and pharmaceutical compositions containing them |
-
1978
- 1978-11-06 JP JP13715778A patent/JPS5564588A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100420663B1 (en) * | 2001-01-09 | 2004-03-02 | 주식회사 켐온 | Novel Quinoline derivatives, the process for the preparation thereof and pharmaceutical compositions containing them |
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