JPS56142283A - Penem-3-carboxylic acid derivative and its preparation - Google Patents

Penem-3-carboxylic acid derivative and its preparation

Info

Publication number
JPS56142283A
JPS56142283A JP3352980A JP3352980A JPS56142283A JP S56142283 A JPS56142283 A JP S56142283A JP 3352980 A JP3352980 A JP 3352980A JP 3352980 A JP3352980 A JP 3352980A JP S56142283 A JPS56142283 A JP S56142283A
Authority
JP
Japan
Prior art keywords
compound
formula
alkyl
halogen
penem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP3352980A
Other languages
Japanese (ja)
Other versions
JPH0325435B2 (en
Inventor
Tetsuo Miyadera
Masao Sugimura
Teruo Tanaka
Toshihiko Hashimoto
Kimio Iino
Shinichi Sugawara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP3352980A priority Critical patent/JPS56142283A/en
Priority to SE8101464A priority patent/SE8101464L/en
Priority to ES500253A priority patent/ES8205808A1/en
Priority to DE19813109086 priority patent/DE3109086A1/en
Priority to PL23007481A priority patent/PL230074A1/xx
Priority to IT67330/81A priority patent/IT1172228B/en
Priority to DD81228171A priority patent/DD157801A5/en
Priority to CH1634/81A priority patent/CH653034A5/en
Priority to NL8101167A priority patent/NL8101167A/en
Priority to GB8107415A priority patent/GB2074563B/en
Priority to FR8104709A priority patent/FR2477547A1/en
Priority to DK108581A priority patent/DK108581A/en
Publication of JPS56142283A publication Critical patent/JPS56142283A/en
Priority to US06/582,152 priority patent/US4639441A/en
Publication of JPH0325435B2 publication Critical patent/JPH0325435B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

NEW MATERIAL:A compound of formula I (R1 is H, alkyl, alkoxyl, etc.; R2 is H, alkyl, aralkyl, etc. optionally substituted by halogen; R3 is H or a protecting group of the carboxyl group; A is alkylene) and a pharamcologically acceptable salt thereof.
EXAMPLE: 2-(2-Oxopropylthio)penem-3-carboxylic acid.
USE: An antimicrobial agent and a synthetic intermediate therefor effective against a wide range of pathogenic germs including Gram-positive and Gram-negative bacteria.
PROCESS: A compound of formula II (R5 is H, alkyl, etc.; R6 is a protecting group of the carboxyl group; R7 is lower alkyl) is treated with a base and then reacted with CS2 and further with a compound of formula III (X is halogen; Ra 2 is a part of R2) to give a compound of formula IV, which is then halogenated to give a compound of formula V (Y is halogen) and then cyclized with a base. The protecting group is removed if necessary to afford the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP3352980A 1980-03-10 1980-03-17 Penem-3-carboxylic acid derivative and its preparation Granted JPS56142283A (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
JP3352980A JPS56142283A (en) 1980-03-17 1980-03-17 Penem-3-carboxylic acid derivative and its preparation
SE8101464A SE8101464L (en) 1980-03-10 1981-03-09 2-PENEM-3-CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND USE
CH1634/81A CH653034A5 (en) 1980-03-10 1981-03-10 2-THIOXOPENAM-3-CARBONIC ACID DERIVATIVES AND ITS PHARMACEUTICAL PREPARATION CONTAINING THEIR TAUTOMERS AND THE FIRST COMPOUNDS.
GB8107415A GB2074563B (en) 1980-03-10 1981-03-10 2-penem-3-carboxylic acid derivatives their preparation and use
PL23007481A PL230074A1 (en) 1980-03-10 1981-03-10
IT67330/81A IT1172228B (en) 1980-03-10 1981-03-10 2 PENEM 3 CARBOXYLIC ACID DERIVATIVES THEIR PREPARATION AND USE AS ANTIBIOTICS
DD81228171A DD157801A5 (en) 1980-03-10 1981-03-10 PROCESS FOR PREPARING 2-PENEM-3-CARBOXYLIC ACID ABKOEMMLINGEN
ES500253A ES8205808A1 (en) 1980-03-10 1981-03-10 2-penem-3-carboxylic acid derivatives and use
NL8101167A NL8101167A (en) 1980-03-10 1981-03-10 2-PENEM-3-CARBONIC ACID COMPOUNDS, THEIR PREPARATION AND USE.
DE19813109086 DE3109086A1 (en) 1980-03-10 1981-03-10 2-PENEM-3-CARBONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE
FR8104709A FR2477547A1 (en) 1980-03-10 1981-03-10 DERIVATIVES OF 2-PENEME-3-CARBOXYLIC ACID, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
DK108581A DK108581A (en) 1980-03-10 1981-03-10 2-PENEM-3-CARBOXYLIC ACID DERIVATIVES AND PROCEDURES FOR PREPARING IT
US06/582,152 US4639441A (en) 1980-03-10 1984-02-24 2-penem-3-carboxylic acid derivatives and use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3352980A JPS56142283A (en) 1980-03-17 1980-03-17 Penem-3-carboxylic acid derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS56142283A true JPS56142283A (en) 1981-11-06
JPH0325435B2 JPH0325435B2 (en) 1991-04-05

Family

ID=12389067

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3352980A Granted JPS56142283A (en) 1980-03-10 1980-03-17 Penem-3-carboxylic acid derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS56142283A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59139386A (en) * 1983-01-25 1984-08-10 メルク　エンド　カムパニー　インコーポレーテツド Manufacture of 2-unsaturated alkylthio-pen-2-em-3-carboxylicacids, substituted 2-thioxopenam and 2-substituted thiopenem

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4163337A4 (en) 2020-06-03 2023-11-29 Denka Company Limited Soft-magnetic-powder-containing resin composition having electromagnetic-wave shielding performance and molded article

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53137951A (en) * 1977-05-09 1978-12-01 Ciba Geigy Ag Thiaaaza compound having betaalactum ring
JPS5488291A (en) * 1977-11-17 1979-07-13 Merck & Co Inc Substituteddpenn22mmcarboxylic acids
JPS54119486A (en) * 1978-02-02 1979-09-17 Ciba Geigy Ag 66substituted thiaaaza compound
JPS559034A (en) * 1978-07-05 1980-01-22 Sankyo Co Ltd Penem derivative and its preparation
JPS55105686A (en) * 1979-01-10 1980-08-13 Schering Corp Organic compound*its manufacture and medical composition containing it

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53137951A (en) * 1977-05-09 1978-12-01 Ciba Geigy Ag Thiaaaza compound having betaalactum ring
JPS5488291A (en) * 1977-11-17 1979-07-13 Merck & Co Inc Substituteddpenn22mmcarboxylic acids
JPS54119486A (en) * 1978-02-02 1979-09-17 Ciba Geigy Ag 66substituted thiaaaza compound
JPS559034A (en) * 1978-07-05 1980-01-22 Sankyo Co Ltd Penem derivative and its preparation
JPS55105686A (en) * 1979-01-10 1980-08-13 Schering Corp Organic compound*its manufacture and medical composition containing it

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59139386A (en) * 1983-01-25 1984-08-10 メルク　エンド　カムパニー　インコーポレーテツド Manufacture of 2-unsaturated alkylthio-pen-2-em-3-carboxylicacids, substituted 2-thioxopenam and 2-substituted thiopenem
JPH0516433B2 (en) * 1983-01-25 1993-03-04 Merck & Co Inc

Also Published As

Publication number Publication date
JPH0325435B2 (en) 1991-04-05

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