JPS572289A - Production of penem-3-carboxylic derivative - Google Patents

Production of penem-3-carboxylic derivative

Info

Publication number
JPS572289A
JPS572289A JP7476180A JP7476180A JPS572289A JP S572289 A JPS572289 A JP S572289A JP 7476180 A JP7476180 A JP 7476180A JP 7476180 A JP7476180 A JP 7476180A JP S572289 A JPS572289 A JP S572289A
Authority
JP
Japan
Prior art keywords
compound
formula
alkyl
penem
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP7476180A
Other languages
Japanese (ja)
Other versions
JPS642117B2 (en
Inventor
Tetsuo Miyadera
Masao Sugimura
Teruo Tanaka
Toshihiko Hashimoto
Kimio Iino
Shinichi Sugawara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP7476180A priority Critical patent/JPS572289A/en
Priority to SE8101464A priority patent/SE8101464L/en
Priority to GB8107415A priority patent/GB2074563B/en
Priority to DD81228171A priority patent/DD157801A5/en
Priority to NL8101167A priority patent/NL8101167A/en
Priority to ES500253A priority patent/ES8205808A1/en
Priority to CH1634/81A priority patent/CH653034A5/en
Priority to DE19813109086 priority patent/DE3109086A1/en
Priority to DK108581A priority patent/DK108581A/en
Priority to IT67330/81A priority patent/IT1172228B/en
Priority to FR8104709A priority patent/FR2477547A1/en
Priority to PL23007481A priority patent/PL230074A1/xx
Publication of JPS572289A publication Critical patent/JPS572289A/en
Priority to US06/582,152 priority patent/US4639441A/en
Publication of JPS642117B2 publication Critical patent/JPS642117B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:The titled compound of formula 1 (R1 is H, alkyl, alkoxy; R2 is H, alkyl, aralkyl; R3 is H, carboxyl-protecting group; A is alkylene), their pharmacologically permissible salts and compounds of formula 2 (R1' is H, alkyl; R3' is carboxyl-protecting group).
EXAMPLE: 2-(Carbamoylmethylthio)penem-3-carboxylic acid.
USE: Antibacterial and its synthetic intermediate: they are effective against a wide range of pahtogenic bacteria including gram-positive and -negative bacteria.
PREPARATION: For example, the compound of formula 5 (Y is halogen) is cyclized in the presence of a base to give the compound of formula 2. Then, the compound is made to react with the compound of formula 3 to form the compound 4 and, when needed, the protecting groups are removed to give the compound of formula 1.
COPYRIGHT: (C)1982,JPO&Japio
JP7476180A 1980-03-10 1980-06-03 Production of penem-3-carboxylic derivative Granted JPS572289A (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
JP7476180A JPS572289A (en) 1980-06-03 1980-06-03 Production of penem-3-carboxylic derivative
SE8101464A SE8101464L (en) 1980-03-10 1981-03-09 2-PENEM-3-CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND USE
DE19813109086 DE3109086A1 (en) 1980-03-10 1981-03-10 2-PENEM-3-CARBONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE
IT67330/81A IT1172228B (en) 1980-03-10 1981-03-10 2 PENEM 3 CARBOXYLIC ACID DERIVATIVES THEIR PREPARATION AND USE AS ANTIBIOTICS
NL8101167A NL8101167A (en) 1980-03-10 1981-03-10 2-PENEM-3-CARBONIC ACID COMPOUNDS, THEIR PREPARATION AND USE.
ES500253A ES8205808A1 (en) 1980-03-10 1981-03-10 2-penem-3-carboxylic acid derivatives and use
CH1634/81A CH653034A5 (en) 1980-03-10 1981-03-10 2-THIOXOPENAM-3-CARBONIC ACID DERIVATIVES AND ITS PHARMACEUTICAL PREPARATION CONTAINING THEIR TAUTOMERS AND THE FIRST COMPOUNDS.
GB8107415A GB2074563B (en) 1980-03-10 1981-03-10 2-penem-3-carboxylic acid derivatives their preparation and use
DK108581A DK108581A (en) 1980-03-10 1981-03-10 2-PENEM-3-CARBOXYLIC ACID DERIVATIVES AND PROCEDURES FOR PREPARING IT
DD81228171A DD157801A5 (en) 1980-03-10 1981-03-10 PROCESS FOR PREPARING 2-PENEM-3-CARBOXYLIC ACID ABKOEMMLINGEN
FR8104709A FR2477547A1 (en) 1980-03-10 1981-03-10 DERIVATIVES OF 2-PENEME-3-CARBOXYLIC ACID, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
PL23007481A PL230074A1 (en) 1980-03-10 1981-03-10
US06/582,152 US4639441A (en) 1980-03-10 1984-02-24 2-penem-3-carboxylic acid derivatives and use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7476180A JPS572289A (en) 1980-06-03 1980-06-03 Production of penem-3-carboxylic derivative

Publications (2)

Publication Number Publication Date
JPS572289A true JPS572289A (en) 1982-01-07
JPS642117B2 JPS642117B2 (en) 1989-01-13

Family

ID=13556575

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7476180A Granted JPS572289A (en) 1980-03-10 1980-06-03 Production of penem-3-carboxylic derivative

Country Status (1)

Country Link
JP (1) JPS572289A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59139386A (en) * 1983-01-25 1984-08-10 メルク　エンド　カムパニー　インコーポレーテツド Manufacture of 2-unsaturated alkylthio-pen-2-em-3-carboxylicacids, substituted 2-thioxopenam and 2-substituted thiopenem
JPH07678U (en) * 1993-05-14 1995-01-06 株式会社明電舎 Industrial manipulator master arm

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59139386A (en) * 1983-01-25 1984-08-10 メルク　エンド　カムパニー　インコーポレーテツド Manufacture of 2-unsaturated alkylthio-pen-2-em-3-carboxylicacids, substituted 2-thioxopenam and 2-substituted thiopenem
JPH0516433B2 (en) * 1983-01-25 1993-03-04 Merck & Co Inc
JPH07678U (en) * 1993-05-14 1995-01-06 株式会社明電舎 Industrial manipulator master arm

Also Published As

Publication number Publication date
JPS642117B2 (en) 1989-01-13

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