JPS5488276A - 6- and 7-carbamoylquinoline derivative - Google Patents
6- and 7-carbamoylquinoline derivativeInfo
- Publication number
- JPS5488276A JPS5488276A JP15296477A JP15296477A JPS5488276A JP S5488276 A JPS5488276 A JP S5488276A JP 15296477 A JP15296477 A JP 15296477A JP 15296477 A JP15296477 A JP 15296477A JP S5488276 A JPS5488276 A JP S5488276A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- group
- enamine
- condensation
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Quinoline Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:6- and 7-Carbamoylquinoline derivatives of formula I (the quinoline ring is substituted with the group of formula II in the 6 or 7 position; R1, R2, R3 are H or lower alkyl).
EXAMPLE: 6-Carbamoyl-1,4-dihydro-4-oxoquinoline-3-carboxylic ethyl ester.
USE: Medicines having activity inhibiting enzymes and the respiration of cells and antibacterial activity against gram-positive and -negative bacteria.
PREPARATION: The condensation of an aminobenzene derivative of formula III (the benzene ring is substituted with the group of formula II in the 3 or 4 position) with an alkoxymethylenemalonic ester gives an enamine of formula V. Then the ring closure of the enamine of formula V is conducted to obtain the objective compound of formula I. Some of compounds of formula III are novel and these compounds are prepared by the condensation of a acid halide of nitrobenzoic acid with an amine and reducing the nitro group of the resulting amide.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15296477A JPS5488276A (en) | 1977-12-21 | 1977-12-21 | 6- and 7-carbamoylquinoline derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15296477A JPS5488276A (en) | 1977-12-21 | 1977-12-21 | 6- and 7-carbamoylquinoline derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5488276A true JPS5488276A (en) | 1979-07-13 |
Family
ID=15551997
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15296477A Pending JPS5488276A (en) | 1977-12-21 | 1977-12-21 | 6- and 7-carbamoylquinoline derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5488276A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5807869A (en) * | 1995-10-19 | 1998-09-15 | Takeda Chemical Industries, Ltd. | Quinoline derivatives, their production and use |
-
1977
- 1977-12-21 JP JP15296477A patent/JPS5488276A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5807869A (en) * | 1995-10-19 | 1998-09-15 | Takeda Chemical Industries, Ltd. | Quinoline derivatives, their production and use |
US6087503A (en) * | 1995-10-19 | 2000-07-11 | Takeda Chemical Industries Ltd. | Quinoline derivatives, their production and use |
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